Clinical Significance of Preoperative Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Breast Cancer

Yutaka Ogasawara, Seiji Yoshitomi, Shuhei Sato, Hiroyoshi Doihara

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Lymphoscintigraphy (LSG) has been widely used as an additional modality to sentinel lymph node biopsy (SLNB) using isotope. However, the significance of the number of LSG-visualized axillary nodes has not been fully understood. We analyzed this and discussed its potential as a modality to complement SLNB. Methods: Ninety-one breasts and axillary lymph nodal status were evaluated retrospectively. All patients were examined by LSG using isotope and subsequently by SLNB. Results: Nine patients (9.9%) had no LSG-visualized axillary node, while 61 patients (67.0%) had only 1 node, and 21 patients (23.1%) had multiple nodes. Overall, sentinel lymph node (SLN) identification rate was 96.7%, and the mean number of removed SLNs was 1.5 nodes per patient. In patients with nonvisualized nodes, 66.7% of SLNs were successfully identified, while 100% of SLNs were identified in those with LSG-visualized nodes. Compared with patients with less than one visualized node, significantly more SLNs were removed in patients with multiple visualized nodes. The number of LSG-visualized nodes correlated with that of metastatic nodes. Conclusions: Preoperative LSG is effective in evaluating SLN status, and the LSG status could be associated with the number of dissected SLN. Moreover, the results of LSG potentially reflect the histological nodal status.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalJournal of Surgical Research
Volume148
Issue number2
DOIs
Publication statusPublished - Aug 2008

Fingerprint

Lymphoscintigraphy
Sentinel Lymph Node Biopsy
Breast Neoplasms
Isotopes
Lymph
Breast

Keywords

  • breast cancer
  • lymphoscintigraphy
  • sentinel lymph node biopsy

ASJC Scopus subject areas

  • Surgery

Cite this

Clinical Significance of Preoperative Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Breast Cancer. / Ogasawara, Yutaka; Yoshitomi, Seiji; Sato, Shuhei; Doihara, Hiroyoshi.

In: Journal of Surgical Research, Vol. 148, No. 2, 08.2008, p. 191-196.

Research output: Contribution to journalArticle

@article{ea27ee79280947fea7f589693d9a99f3,
title = "Clinical Significance of Preoperative Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Breast Cancer",
abstract = "Background: Lymphoscintigraphy (LSG) has been widely used as an additional modality to sentinel lymph node biopsy (SLNB) using isotope. However, the significance of the number of LSG-visualized axillary nodes has not been fully understood. We analyzed this and discussed its potential as a modality to complement SLNB. Methods: Ninety-one breasts and axillary lymph nodal status were evaluated retrospectively. All patients were examined by LSG using isotope and subsequently by SLNB. Results: Nine patients (9.9{\%}) had no LSG-visualized axillary node, while 61 patients (67.0{\%}) had only 1 node, and 21 patients (23.1{\%}) had multiple nodes. Overall, sentinel lymph node (SLN) identification rate was 96.7{\%}, and the mean number of removed SLNs was 1.5 nodes per patient. In patients with nonvisualized nodes, 66.7{\%} of SLNs were successfully identified, while 100{\%} of SLNs were identified in those with LSG-visualized nodes. Compared with patients with less than one visualized node, significantly more SLNs were removed in patients with multiple visualized nodes. The number of LSG-visualized nodes correlated with that of metastatic nodes. Conclusions: Preoperative LSG is effective in evaluating SLN status, and the LSG status could be associated with the number of dissected SLN. Moreover, the results of LSG potentially reflect the histological nodal status.",
keywords = "breast cancer, lymphoscintigraphy, sentinel lymph node biopsy",
author = "Yutaka Ogasawara and Seiji Yoshitomi and Shuhei Sato and Hiroyoshi Doihara",
year = "2008",
month = "8",
doi = "10.1016/j.jss.2007.10.022",
language = "English",
volume = "148",
pages = "191--196",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Clinical Significance of Preoperative Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Breast Cancer

AU - Ogasawara, Yutaka

AU - Yoshitomi, Seiji

AU - Sato, Shuhei

AU - Doihara, Hiroyoshi

PY - 2008/8

Y1 - 2008/8

N2 - Background: Lymphoscintigraphy (LSG) has been widely used as an additional modality to sentinel lymph node biopsy (SLNB) using isotope. However, the significance of the number of LSG-visualized axillary nodes has not been fully understood. We analyzed this and discussed its potential as a modality to complement SLNB. Methods: Ninety-one breasts and axillary lymph nodal status were evaluated retrospectively. All patients were examined by LSG using isotope and subsequently by SLNB. Results: Nine patients (9.9%) had no LSG-visualized axillary node, while 61 patients (67.0%) had only 1 node, and 21 patients (23.1%) had multiple nodes. Overall, sentinel lymph node (SLN) identification rate was 96.7%, and the mean number of removed SLNs was 1.5 nodes per patient. In patients with nonvisualized nodes, 66.7% of SLNs were successfully identified, while 100% of SLNs were identified in those with LSG-visualized nodes. Compared with patients with less than one visualized node, significantly more SLNs were removed in patients with multiple visualized nodes. The number of LSG-visualized nodes correlated with that of metastatic nodes. Conclusions: Preoperative LSG is effective in evaluating SLN status, and the LSG status could be associated with the number of dissected SLN. Moreover, the results of LSG potentially reflect the histological nodal status.

AB - Background: Lymphoscintigraphy (LSG) has been widely used as an additional modality to sentinel lymph node biopsy (SLNB) using isotope. However, the significance of the number of LSG-visualized axillary nodes has not been fully understood. We analyzed this and discussed its potential as a modality to complement SLNB. Methods: Ninety-one breasts and axillary lymph nodal status were evaluated retrospectively. All patients were examined by LSG using isotope and subsequently by SLNB. Results: Nine patients (9.9%) had no LSG-visualized axillary node, while 61 patients (67.0%) had only 1 node, and 21 patients (23.1%) had multiple nodes. Overall, sentinel lymph node (SLN) identification rate was 96.7%, and the mean number of removed SLNs was 1.5 nodes per patient. In patients with nonvisualized nodes, 66.7% of SLNs were successfully identified, while 100% of SLNs were identified in those with LSG-visualized nodes. Compared with patients with less than one visualized node, significantly more SLNs were removed in patients with multiple visualized nodes. The number of LSG-visualized nodes correlated with that of metastatic nodes. Conclusions: Preoperative LSG is effective in evaluating SLN status, and the LSG status could be associated with the number of dissected SLN. Moreover, the results of LSG potentially reflect the histological nodal status.

KW - breast cancer

KW - lymphoscintigraphy

KW - sentinel lymph node biopsy

UR - http://www.scopus.com/inward/record.url?scp=46249109792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46249109792&partnerID=8YFLogxK

U2 - 10.1016/j.jss.2007.10.022

DO - 10.1016/j.jss.2007.10.022

M3 - Article

C2 - 18262547

AN - SCOPUS:46249109792

VL - 148

SP - 191

EP - 196

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 2

ER -