Clinical significance of low or negative titer of antibody to hepatitis B core antigen during the course of chronic hepatitis B virus infection in adolescents

Kazuharu Matsuura, Kazuo Tobe, Yoshiaki Iwasaki, Hiroshi Ikeda, Kenji Takahashi, Takao Tsuji

Research output: Contribution to journalArticle

3 Citations (Scopus)


Antibody to hepatitis B core antigen (anti-HBc) was measured by radioimmunoassay in 127 asymptomatic hepatitis B surface antigen (HBsAg) carriers (ASC; mean age 19) who had normal serum alanine aminotrasferase (ALT) levels and 16 patients with chronic hepatitis B (CH; 19). All 16 CH patients, who were positive for hepatitis B e antigen (HBeAg) and 5 ASC cases who were negative for both HBeAg and its antibody (anti-HBe), had high anti-HBc titers. Anti-HBc titers in 27 (56.3%) of the 48 HBeAg-positive ASC and 18 (24.3%) of the 74 anti-HBe-positive ASC were relatively low. Two of the ASC were HBeAgpositive/ anti-HBc-negative. In a follow-up study of the 19 HBeAg-positive ASC with low or negative anti-HBc titers, 5 had abnormal serum ALT levels and increased anti-HBc titers. In contrast, in the other 14 of these subjects, serum ALT levels remained normal and the low anti-HBc titers remained unchanged and/or decreased. The serological profile of HBsAg-positive/low or negative anti-HBc titer and increased anti-HBc titer with abnormal serum ALT levels are not necessarily exceptional in HBeAg-positive adolescent ASC. It is suggested that anti-HBc is associated with the liver damage that occurs before adolescence in chronic hepatitis B virus infection.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalGastroenterologia Japonica
Issue number1
Publication statusPublished - Feb 1 1993



  • antibody to hepatitis B core antigen
  • hepatitis B virus
  • polymerized human serum albumin receptor
  • pre-S antigen
  • seroconversion to anti-HBe

ASJC Scopus subject areas

  • Gastroenterology

Cite this