Clinical significance of low or negative titer of antibody to hepatitis B core antigen during the course of chronic hepatitis B virus infection in adolescents

Kazuharu Matsuura, Kazuo Tobe, Yoshiaki Iwasaki, Hiroshi Ikeda, Kenji Takahashi, Takao Tsuji

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Antibody to hepatitis B core antigen (anti-HBc) was measured by radioimmunoassay in 127 asymptomatic hepatitis B surface antigen (HBsAg) carriers (ASC; mean age 19) who had normal serum alanine aminotrasferase (ALT) levels and 16 patients with chronic hepatitis B (CH; 19). All 16 CH patients, who were positive for hepatitis B e antigen (HBeAg) and 5 ASC cases who were negative for both HBeAg and its antibody (anti-HBe), had high anti-HBc titers. Anti-HBc titers in 27 (56.3%) of the 48 HBeAg-positive ASC and 18 (24.3%) of the 74 anti-HBe-positive ASC were relatively low. Two of the ASC were HBeAgpositive/ anti-HBc-negative. In a follow-up study of the 19 HBeAg-positive ASC with low or negative anti-HBc titers, 5 had abnormal serum ALT levels and increased anti-HBc titers. In contrast, in the other 14 of these subjects, serum ALT levels remained normal and the low anti-HBc titers remained unchanged and/or decreased. The serological profile of HBsAg-positive/low or negative anti-HBc titer and increased anti-HBc titer with abnormal serum ALT levels are not necessarily exceptional in HBeAg-positive adolescent ASC. It is suggested that anti-HBc is associated with the liver damage that occurs before adolescence in chronic hepatitis B virus infection.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalGastroenterologia Japonica
Volume28
Issue number1
DOIs
Publication statusPublished - Feb 1993

Fingerprint

Hepatitis B Core Antigens
Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Hepatitis B e Antigens
Antibodies
Alanine
Hepatitis B Surface Antigens
Serum
Radioimmunoassay
Anti-Idiotypic Antibodies

Keywords

  • antibody to hepatitis B core antigen
  • hepatitis B virus
  • polymerized human serum albumin receptor
  • pre-S antigen
  • seroconversion to anti-HBe

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Clinical significance of low or negative titer of antibody to hepatitis B core antigen during the course of chronic hepatitis B virus infection in adolescents. / Matsuura, Kazuharu; Tobe, Kazuo; Iwasaki, Yoshiaki; Ikeda, Hiroshi; Takahashi, Kenji; Tsuji, Takao.

In: Gastroenterologia Japonica, Vol. 28, No. 1, 02.1993, p. 25-33.

Research output: Contribution to journalArticle

@article{3eabeba3774f4b7d8679fbd5216b5ea9,
title = "Clinical significance of low or negative titer of antibody to hepatitis B core antigen during the course of chronic hepatitis B virus infection in adolescents",
abstract = "Antibody to hepatitis B core antigen (anti-HBc) was measured by radioimmunoassay in 127 asymptomatic hepatitis B surface antigen (HBsAg) carriers (ASC; mean age 19) who had normal serum alanine aminotrasferase (ALT) levels and 16 patients with chronic hepatitis B (CH; 19). All 16 CH patients, who were positive for hepatitis B e antigen (HBeAg) and 5 ASC cases who were negative for both HBeAg and its antibody (anti-HBe), had high anti-HBc titers. Anti-HBc titers in 27 (56.3{\%}) of the 48 HBeAg-positive ASC and 18 (24.3{\%}) of the 74 anti-HBe-positive ASC were relatively low. Two of the ASC were HBeAgpositive/ anti-HBc-negative. In a follow-up study of the 19 HBeAg-positive ASC with low or negative anti-HBc titers, 5 had abnormal serum ALT levels and increased anti-HBc titers. In contrast, in the other 14 of these subjects, serum ALT levels remained normal and the low anti-HBc titers remained unchanged and/or decreased. The serological profile of HBsAg-positive/low or negative anti-HBc titer and increased anti-HBc titer with abnormal serum ALT levels are not necessarily exceptional in HBeAg-positive adolescent ASC. It is suggested that anti-HBc is associated with the liver damage that occurs before adolescence in chronic hepatitis B virus infection.",
keywords = "antibody to hepatitis B core antigen, hepatitis B virus, polymerized human serum albumin receptor, pre-S antigen, seroconversion to anti-HBe",
author = "Kazuharu Matsuura and Kazuo Tobe and Yoshiaki Iwasaki and Hiroshi Ikeda and Kenji Takahashi and Takao Tsuji",
year = "1993",
month = "2",
doi = "10.1007/BF02775000",
language = "English",
volume = "28",
pages = "25--33",
journal = "Journal of Gastroenterology",
issn = "0944-1174",
publisher = "Springer Japan",
number = "1",

}

TY - JOUR

T1 - Clinical significance of low or negative titer of antibody to hepatitis B core antigen during the course of chronic hepatitis B virus infection in adolescents

AU - Matsuura, Kazuharu

AU - Tobe, Kazuo

AU - Iwasaki, Yoshiaki

AU - Ikeda, Hiroshi

AU - Takahashi, Kenji

AU - Tsuji, Takao

PY - 1993/2

Y1 - 1993/2

N2 - Antibody to hepatitis B core antigen (anti-HBc) was measured by radioimmunoassay in 127 asymptomatic hepatitis B surface antigen (HBsAg) carriers (ASC; mean age 19) who had normal serum alanine aminotrasferase (ALT) levels and 16 patients with chronic hepatitis B (CH; 19). All 16 CH patients, who were positive for hepatitis B e antigen (HBeAg) and 5 ASC cases who were negative for both HBeAg and its antibody (anti-HBe), had high anti-HBc titers. Anti-HBc titers in 27 (56.3%) of the 48 HBeAg-positive ASC and 18 (24.3%) of the 74 anti-HBe-positive ASC were relatively low. Two of the ASC were HBeAgpositive/ anti-HBc-negative. In a follow-up study of the 19 HBeAg-positive ASC with low or negative anti-HBc titers, 5 had abnormal serum ALT levels and increased anti-HBc titers. In contrast, in the other 14 of these subjects, serum ALT levels remained normal and the low anti-HBc titers remained unchanged and/or decreased. The serological profile of HBsAg-positive/low or negative anti-HBc titer and increased anti-HBc titer with abnormal serum ALT levels are not necessarily exceptional in HBeAg-positive adolescent ASC. It is suggested that anti-HBc is associated with the liver damage that occurs before adolescence in chronic hepatitis B virus infection.

AB - Antibody to hepatitis B core antigen (anti-HBc) was measured by radioimmunoassay in 127 asymptomatic hepatitis B surface antigen (HBsAg) carriers (ASC; mean age 19) who had normal serum alanine aminotrasferase (ALT) levels and 16 patients with chronic hepatitis B (CH; 19). All 16 CH patients, who were positive for hepatitis B e antigen (HBeAg) and 5 ASC cases who were negative for both HBeAg and its antibody (anti-HBe), had high anti-HBc titers. Anti-HBc titers in 27 (56.3%) of the 48 HBeAg-positive ASC and 18 (24.3%) of the 74 anti-HBe-positive ASC were relatively low. Two of the ASC were HBeAgpositive/ anti-HBc-negative. In a follow-up study of the 19 HBeAg-positive ASC with low or negative anti-HBc titers, 5 had abnormal serum ALT levels and increased anti-HBc titers. In contrast, in the other 14 of these subjects, serum ALT levels remained normal and the low anti-HBc titers remained unchanged and/or decreased. The serological profile of HBsAg-positive/low or negative anti-HBc titer and increased anti-HBc titer with abnormal serum ALT levels are not necessarily exceptional in HBeAg-positive adolescent ASC. It is suggested that anti-HBc is associated with the liver damage that occurs before adolescence in chronic hepatitis B virus infection.

KW - antibody to hepatitis B core antigen

KW - hepatitis B virus

KW - polymerized human serum albumin receptor

KW - pre-S antigen

KW - seroconversion to anti-HBe

UR - http://www.scopus.com/inward/record.url?scp=0027408074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027408074&partnerID=8YFLogxK

U2 - 10.1007/BF02775000

DO - 10.1007/BF02775000

M3 - Article

C2 - 8440421

AN - SCOPUS:0027408074

VL - 28

SP - 25

EP - 33

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

SN - 0944-1174

IS - 1

ER -