Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma

Tsuyoshi Shimo, Satoshi Kubota, Takeshi Goda, Yasuto Yoshihama, Naito Kurio, Takashi Nishida, Poh Sing Ng, Koki Endo, Masaharu Takigawa, Akira Sasaki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Mandibular bone destruction is a frequent occurrence in oral squamous cell carcinoma. However, the relationship between the bone destruction and associated factors is unclear. Here, the role and diagnostic utility of connective tissue growth factor (CCN2) in bone destruction of the mandible was investigated. Patients and Methods: The production of CCN2 was explored by using immunohistochemistry on paraffin-embedded tissues from 20 cases of mandibular squamous cell carcinoma. The effect of CCN2 on osteoclastogenesis was examined in vitro by using total bone marrow cell populations from male mice. Results: Immunohistochemical analysis showed that CCN2-positive signals were closely associated with destructive invasion of the mandible by oral squamous cell carcinomas. Consistent with these results, recombinant human CCN2 (rCCN2) stimulated tartrate-resistant acid phosphatase (TRAP)-positive osteoclastlike cell formation in vitro. Conclusion: CCN2 can be considered a diagnostic marker and target for treatment in oral osteolytic mandibular squamous cell carcinoma.

Original languageEnglish
Pages (from-to)2343-2348
Number of pages6
JournalAnticancer Research
Volume28
Issue number4 C
Publication statusPublished - Jul 2008

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Connective Tissue Growth Factor
Squamous Cell Carcinoma
Mandible
Bone and Bones
Osteogenesis
Bone Marrow Cells
Paraffin
Immunohistochemistry
Population
In Vitro Techniques

Keywords

  • CCN2
  • Mandibular bone destruction
  • Osteoclast

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma. / Shimo, Tsuyoshi; Kubota, Satoshi; Goda, Takeshi; Yoshihama, Yasuto; Kurio, Naito; Nishida, Takashi; Ng, Poh Sing; Endo, Koki; Takigawa, Masaharu; Sasaki, Akira.

In: Anticancer Research, Vol. 28, No. 4 C, 07.2008, p. 2343-2348.

Research output: Contribution to journalArticle

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AU - Yoshihama, Yasuto

AU - Kurio, Naito

AU - Nishida, Takashi

AU - Ng, Poh Sing

AU - Endo, Koki

AU - Takigawa, Masaharu

AU - Sasaki, Akira

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AB - Background: Mandibular bone destruction is a frequent occurrence in oral squamous cell carcinoma. However, the relationship between the bone destruction and associated factors is unclear. Here, the role and diagnostic utility of connective tissue growth factor (CCN2) in bone destruction of the mandible was investigated. Patients and Methods: The production of CCN2 was explored by using immunohistochemistry on paraffin-embedded tissues from 20 cases of mandibular squamous cell carcinoma. The effect of CCN2 on osteoclastogenesis was examined in vitro by using total bone marrow cell populations from male mice. Results: Immunohistochemical analysis showed that CCN2-positive signals were closely associated with destructive invasion of the mandible by oral squamous cell carcinomas. Consistent with these results, recombinant human CCN2 (rCCN2) stimulated tartrate-resistant acid phosphatase (TRAP)-positive osteoclastlike cell formation in vitro. Conclusion: CCN2 can be considered a diagnostic marker and target for treatment in oral osteolytic mandibular squamous cell carcinoma.

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