Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: From a questionnaire for JCOG 1610 study

Hiroshi Urakawa, Tsukasa Yonemoto, Seiichi Matsumoto, Tatsuya Takagi, Kunihiro Asanuma, Munenori Watanuki, Akira Takemoto, Norifumi Naka, Yoshihiro Matsumoto, Akira Kawai, Toshiyuki Kunisada, Tadahiko Kubo, Makoto Emori, Hiroaki Hiraga, Hiroshi Hatano, Satoshi Tsukushi, Yoshihiro Nishida, Toshihiro Akisue, Takeshi Morii, Mitsuru TakahashiAkihito Nagano, Hideki Yoshikawa, Kenji Sato, Masanori Kawano, Koji Hiraoka, Kazuhiro Tanaka, Yukihide Iwamoto, Toshihumi Ozaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Giant cell tumor of bone (GCTB) is an intermediate tumor known to be locally aggressive, but rarely metastasizing. To plan a prospective study of GCTB, we performed a questionnaire survey for institutions participating in the Bone and Soft Tissue Tumor Study Group (BSTTSG) in the Japan Clinical Oncology Group (JCOG) in 2015. Methods: We reviewed 158 consecutive patients with primary GCTB treated with curettage without perioperative denosumab from 2008 to 2010 in Japan. We investigated local and distant recurrence rates after definitive curettage. We also investigated the recurrence rate after treatment with preoperative and/or postoperative denosumab with curettage in recent years. There were 40 patients treated with perioperative denosumab, and the factors affecting recurrence in them were investigated. Results: Answers were available from 24 of 30 institutions (80.0%) participating in JCOG BSTTSG. Thirty (19.0%) and 4 (2.5%) of 158 patients developed local and distant recurrence after curettage without perioperative denosumab from 2008 to 2010, respectively. Campanacci grade and embolization before surgery were significantly associated with increasing incidence of local recurrence after curettage (p=0.034 and p=0.022, respectively). In patients treated with perioperative desnosumab, 120mg denosumab was administered subcutaneously for a median 6 (2-41) and 6 (1-14) times in preoperative and postoperative settings, respectively. The recurrence rates were 6 of 21 (28.6%), 2 of 9 (22.2%), and 0 of 10 (0.0%) in the preoperative, postoperative, and both pre- and postoperative denosumab treatment groups, respectively. With all of the preoperative treatments, administration exceeding five times was significantly associated with a decreased incidence of local recurrence after curettage (p<0.001). Conclusion: The recurrence rate of GCTB was still high after curettage, especially in Campanacci grade III, and improvements in the therapeutic strategy are needed in this cohort. There is a possibility that a sufficient dose of preoperative denosumab can reduce recurrence after curettage. Recently, we have started a clinical trial, JCOG1610, to investigate the efficacy of preoperative denosumab in patients who can be treated with curettage in GCTB.

Original languageEnglish
Article number160
JournalWorld Journal of Surgical Oncology
Volume16
Issue number1
DOIs
Publication statusPublished - Aug 8 2018

Fingerprint

Giant Cell Tumor of Bone
Medical Oncology
Curettage
Japan
Recurrence
Surveys and Questionnaires
Denosumab
Bone and Bones
Neoplasms
Incidence
Therapeutics
Clinical Trials
Prospective Studies

Keywords

  • Denosumab
  • Giant cell tumor of bone
  • Japan
  • Outcome

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan : From a questionnaire for JCOG 1610 study. / Urakawa, Hiroshi; Yonemoto, Tsukasa; Matsumoto, Seiichi; Takagi, Tatsuya; Asanuma, Kunihiro; Watanuki, Munenori; Takemoto, Akira; Naka, Norifumi; Matsumoto, Yoshihiro; Kawai, Akira; Kunisada, Toshiyuki; Kubo, Tadahiko; Emori, Makoto; Hiraga, Hiroaki; Hatano, Hiroshi; Tsukushi, Satoshi; Nishida, Yoshihiro; Akisue, Toshihiro; Morii, Takeshi; Takahashi, Mitsuru; Nagano, Akihito; Yoshikawa, Hideki; Sato, Kenji; Kawano, Masanori; Hiraoka, Koji; Tanaka, Kazuhiro; Iwamoto, Yukihide; Ozaki, Toshihumi.

In: World Journal of Surgical Oncology, Vol. 16, No. 1, 160, 08.08.2018.

Research output: Contribution to journalArticle

Urakawa, H, Yonemoto, T, Matsumoto, S, Takagi, T, Asanuma, K, Watanuki, M, Takemoto, A, Naka, N, Matsumoto, Y, Kawai, A, Kunisada, T, Kubo, T, Emori, M, Hiraga, H, Hatano, H, Tsukushi, S, Nishida, Y, Akisue, T, Morii, T, Takahashi, M, Nagano, A, Yoshikawa, H, Sato, K, Kawano, M, Hiraoka, K, Tanaka, K, Iwamoto, Y & Ozaki, T 2018, 'Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: From a questionnaire for JCOG 1610 study', World Journal of Surgical Oncology, vol. 16, no. 1, 160. https://doi.org/10.1186/s12957-018-1459-6
Urakawa, Hiroshi ; Yonemoto, Tsukasa ; Matsumoto, Seiichi ; Takagi, Tatsuya ; Asanuma, Kunihiro ; Watanuki, Munenori ; Takemoto, Akira ; Naka, Norifumi ; Matsumoto, Yoshihiro ; Kawai, Akira ; Kunisada, Toshiyuki ; Kubo, Tadahiko ; Emori, Makoto ; Hiraga, Hiroaki ; Hatano, Hiroshi ; Tsukushi, Satoshi ; Nishida, Yoshihiro ; Akisue, Toshihiro ; Morii, Takeshi ; Takahashi, Mitsuru ; Nagano, Akihito ; Yoshikawa, Hideki ; Sato, Kenji ; Kawano, Masanori ; Hiraoka, Koji ; Tanaka, Kazuhiro ; Iwamoto, Yukihide ; Ozaki, Toshihumi. / Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan : From a questionnaire for JCOG 1610 study. In: World Journal of Surgical Oncology. 2018 ; Vol. 16, No. 1.
@article{61462967a397473baf1ae38f9461a598,
title = "Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: From a questionnaire for JCOG 1610 study",
abstract = "Background: Giant cell tumor of bone (GCTB) is an intermediate tumor known to be locally aggressive, but rarely metastasizing. To plan a prospective study of GCTB, we performed a questionnaire survey for institutions participating in the Bone and Soft Tissue Tumor Study Group (BSTTSG) in the Japan Clinical Oncology Group (JCOG) in 2015. Methods: We reviewed 158 consecutive patients with primary GCTB treated with curettage without perioperative denosumab from 2008 to 2010 in Japan. We investigated local and distant recurrence rates after definitive curettage. We also investigated the recurrence rate after treatment with preoperative and/or postoperative denosumab with curettage in recent years. There were 40 patients treated with perioperative denosumab, and the factors affecting recurrence in them were investigated. Results: Answers were available from 24 of 30 institutions (80.0{\%}) participating in JCOG BSTTSG. Thirty (19.0{\%}) and 4 (2.5{\%}) of 158 patients developed local and distant recurrence after curettage without perioperative denosumab from 2008 to 2010, respectively. Campanacci grade and embolization before surgery were significantly associated with increasing incidence of local recurrence after curettage (p=0.034 and p=0.022, respectively). In patients treated with perioperative desnosumab, 120mg denosumab was administered subcutaneously for a median 6 (2-41) and 6 (1-14) times in preoperative and postoperative settings, respectively. The recurrence rates were 6 of 21 (28.6{\%}), 2 of 9 (22.2{\%}), and 0 of 10 (0.0{\%}) in the preoperative, postoperative, and both pre- and postoperative denosumab treatment groups, respectively. With all of the preoperative treatments, administration exceeding five times was significantly associated with a decreased incidence of local recurrence after curettage (p<0.001). Conclusion: The recurrence rate of GCTB was still high after curettage, especially in Campanacci grade III, and improvements in the therapeutic strategy are needed in this cohort. There is a possibility that a sufficient dose of preoperative denosumab can reduce recurrence after curettage. Recently, we have started a clinical trial, JCOG1610, to investigate the efficacy of preoperative denosumab in patients who can be treated with curettage in GCTB.",
keywords = "Denosumab, Giant cell tumor of bone, Japan, Outcome",
author = "Hiroshi Urakawa and Tsukasa Yonemoto and Seiichi Matsumoto and Tatsuya Takagi and Kunihiro Asanuma and Munenori Watanuki and Akira Takemoto and Norifumi Naka and Yoshihiro Matsumoto and Akira Kawai and Toshiyuki Kunisada and Tadahiko Kubo and Makoto Emori and Hiroaki Hiraga and Hiroshi Hatano and Satoshi Tsukushi and Yoshihiro Nishida and Toshihiro Akisue and Takeshi Morii and Mitsuru Takahashi and Akihito Nagano and Hideki Yoshikawa and Kenji Sato and Masanori Kawano and Koji Hiraoka and Kazuhiro Tanaka and Yukihide Iwamoto and Toshihumi Ozaki",
year = "2018",
month = "8",
day = "8",
doi = "10.1186/s12957-018-1459-6",
language = "English",
volume = "16",
journal = "World Journal of Surgical Oncology",
issn = "1477-7819",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan

T2 - From a questionnaire for JCOG 1610 study

AU - Urakawa, Hiroshi

AU - Yonemoto, Tsukasa

AU - Matsumoto, Seiichi

AU - Takagi, Tatsuya

AU - Asanuma, Kunihiro

AU - Watanuki, Munenori

AU - Takemoto, Akira

AU - Naka, Norifumi

AU - Matsumoto, Yoshihiro

AU - Kawai, Akira

AU - Kunisada, Toshiyuki

AU - Kubo, Tadahiko

AU - Emori, Makoto

AU - Hiraga, Hiroaki

AU - Hatano, Hiroshi

AU - Tsukushi, Satoshi

AU - Nishida, Yoshihiro

AU - Akisue, Toshihiro

AU - Morii, Takeshi

AU - Takahashi, Mitsuru

AU - Nagano, Akihito

AU - Yoshikawa, Hideki

AU - Sato, Kenji

AU - Kawano, Masanori

AU - Hiraoka, Koji

AU - Tanaka, Kazuhiro

AU - Iwamoto, Yukihide

AU - Ozaki, Toshihumi

PY - 2018/8/8

Y1 - 2018/8/8

N2 - Background: Giant cell tumor of bone (GCTB) is an intermediate tumor known to be locally aggressive, but rarely metastasizing. To plan a prospective study of GCTB, we performed a questionnaire survey for institutions participating in the Bone and Soft Tissue Tumor Study Group (BSTTSG) in the Japan Clinical Oncology Group (JCOG) in 2015. Methods: We reviewed 158 consecutive patients with primary GCTB treated with curettage without perioperative denosumab from 2008 to 2010 in Japan. We investigated local and distant recurrence rates after definitive curettage. We also investigated the recurrence rate after treatment with preoperative and/or postoperative denosumab with curettage in recent years. There were 40 patients treated with perioperative denosumab, and the factors affecting recurrence in them were investigated. Results: Answers were available from 24 of 30 institutions (80.0%) participating in JCOG BSTTSG. Thirty (19.0%) and 4 (2.5%) of 158 patients developed local and distant recurrence after curettage without perioperative denosumab from 2008 to 2010, respectively. Campanacci grade and embolization before surgery were significantly associated with increasing incidence of local recurrence after curettage (p=0.034 and p=0.022, respectively). In patients treated with perioperative desnosumab, 120mg denosumab was administered subcutaneously for a median 6 (2-41) and 6 (1-14) times in preoperative and postoperative settings, respectively. The recurrence rates were 6 of 21 (28.6%), 2 of 9 (22.2%), and 0 of 10 (0.0%) in the preoperative, postoperative, and both pre- and postoperative denosumab treatment groups, respectively. With all of the preoperative treatments, administration exceeding five times was significantly associated with a decreased incidence of local recurrence after curettage (p<0.001). Conclusion: The recurrence rate of GCTB was still high after curettage, especially in Campanacci grade III, and improvements in the therapeutic strategy are needed in this cohort. There is a possibility that a sufficient dose of preoperative denosumab can reduce recurrence after curettage. Recently, we have started a clinical trial, JCOG1610, to investigate the efficacy of preoperative denosumab in patients who can be treated with curettage in GCTB.

AB - Background: Giant cell tumor of bone (GCTB) is an intermediate tumor known to be locally aggressive, but rarely metastasizing. To plan a prospective study of GCTB, we performed a questionnaire survey for institutions participating in the Bone and Soft Tissue Tumor Study Group (BSTTSG) in the Japan Clinical Oncology Group (JCOG) in 2015. Methods: We reviewed 158 consecutive patients with primary GCTB treated with curettage without perioperative denosumab from 2008 to 2010 in Japan. We investigated local and distant recurrence rates after definitive curettage. We also investigated the recurrence rate after treatment with preoperative and/or postoperative denosumab with curettage in recent years. There were 40 patients treated with perioperative denosumab, and the factors affecting recurrence in them were investigated. Results: Answers were available from 24 of 30 institutions (80.0%) participating in JCOG BSTTSG. Thirty (19.0%) and 4 (2.5%) of 158 patients developed local and distant recurrence after curettage without perioperative denosumab from 2008 to 2010, respectively. Campanacci grade and embolization before surgery were significantly associated with increasing incidence of local recurrence after curettage (p=0.034 and p=0.022, respectively). In patients treated with perioperative desnosumab, 120mg denosumab was administered subcutaneously for a median 6 (2-41) and 6 (1-14) times in preoperative and postoperative settings, respectively. The recurrence rates were 6 of 21 (28.6%), 2 of 9 (22.2%), and 0 of 10 (0.0%) in the preoperative, postoperative, and both pre- and postoperative denosumab treatment groups, respectively. With all of the preoperative treatments, administration exceeding five times was significantly associated with a decreased incidence of local recurrence after curettage (p<0.001). Conclusion: The recurrence rate of GCTB was still high after curettage, especially in Campanacci grade III, and improvements in the therapeutic strategy are needed in this cohort. There is a possibility that a sufficient dose of preoperative denosumab can reduce recurrence after curettage. Recently, we have started a clinical trial, JCOG1610, to investigate the efficacy of preoperative denosumab in patients who can be treated with curettage in GCTB.

KW - Denosumab

KW - Giant cell tumor of bone

KW - Japan

KW - Outcome

UR - http://www.scopus.com/inward/record.url?scp=85054930261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054930261&partnerID=8YFLogxK

U2 - 10.1186/s12957-018-1459-6

DO - 10.1186/s12957-018-1459-6

M3 - Article

C2 - 30089488

AN - SCOPUS:85054930261

VL - 16

JO - World Journal of Surgical Oncology

JF - World Journal of Surgical Oncology

SN - 1477-7819

IS - 1

M1 - 160

ER -