Clinical manifestations of skin, lung and muscle diseases in dermatomyositis positive for anti-aminoacyl tRNA synthetase antibodies

Hiroko Fukamatsu, Yoji Hirai, Tomoko Miyake, Tatsuya Kaji, Shin Morizane, Emi Yokoyama, Toshihisa Hamada, Takashi Oono, Yoshinobu Koyama, Seiichiro Norikane, Keiji Iwatsuki

Research output: Contribution to journalArticle

Abstract

Patients with dermatomyositis positive for anti-aminoacyl tRNA synthetase (ARS) antibodies, also known as antisynthetase syndrome (ASS), frequently present with mechanic's hand and interstitial lung disease (ILD). We first screened the antibody profiles of 59 patients with dermatomyositis, and then examined the cutaneous, muscular and pulmonary manifestations characteristic for patients with ASS. The anti-ARS antibodies Jo-1, PL-7, PL-12, EJ and KS, along with antibodies to TIF1-γ, MDA5 and Mi-2, were examined. Among the 59 patients, 20, 21, 15 and three patients were classified into the ASS, non-ASS, myositis-specific antibody-negative and unknown groups, respectively. Five of 16 patients (31%) with ASS had six relatives with a history of collagen diseases, within the second degree of relationship, including two cases of dermatomyositis (vs the non-ASS group, P = 0.018). Patients with ASS more frequently presented with fever and arthralgia, and had elevated levels of C-reactive protein. Nine of the 11 finger lesions (82%) clinically diagnosed as mechanic's hands showed a psoriasiform tissue reaction. ILD was observed in 19 of 20 patients (95%) with ASS, and eight of 21 patients (38%) in the non-ASS group, in which six patients possessed anti-MDA5 antibody. Patients with ASS showed higher serum levels of muscle enzymes, and four of 12 patients (33%) had fasciitis-dominant myopathy, while only one of 11 patients (9%) in the non-ASS group had fasciitis-dominant myopathy. Patients with ASS often present with a psoriasiform tissue reaction in the hand lesions and fasciitis-dominant myopathy, and the relatives of those with ASS are at high risk for collagen diseases.

Original languageEnglish
JournalJournal of Dermatology
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Skin Manifestations
Amino Acyl-tRNA Synthetases
Dermatomyositis
Lung Diseases
Muscles
Antibodies
Fasciitis
Muscular Diseases
Collagen Diseases
Hand
Interstitial Lung Diseases
Antisynthetase syndrome
Myositis
Arthralgia
C-Reactive Protein

Keywords

  • aminoacyl tRNA synthetase
  • familial occurrence
  • interstitial lung disease
  • mechanic's hand
  • myositis/fasciitis

ASJC Scopus subject areas

  • Dermatology

Cite this

Clinical manifestations of skin, lung and muscle diseases in dermatomyositis positive for anti-aminoacyl tRNA synthetase antibodies. / Fukamatsu, Hiroko; Hirai, Yoji; Miyake, Tomoko; Kaji, Tatsuya; Morizane, Shin; Yokoyama, Emi; Hamada, Toshihisa; Oono, Takashi; Koyama, Yoshinobu; Norikane, Seiichiro; Iwatsuki, Keiji.

In: Journal of Dermatology, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "Patients with dermatomyositis positive for anti-aminoacyl tRNA synthetase (ARS) antibodies, also known as antisynthetase syndrome (ASS), frequently present with mechanic's hand and interstitial lung disease (ILD). We first screened the antibody profiles of 59 patients with dermatomyositis, and then examined the cutaneous, muscular and pulmonary manifestations characteristic for patients with ASS. The anti-ARS antibodies Jo-1, PL-7, PL-12, EJ and KS, along with antibodies to TIF1-γ, MDA5 and Mi-2, were examined. Among the 59 patients, 20, 21, 15 and three patients were classified into the ASS, non-ASS, myositis-specific antibody-negative and unknown groups, respectively. Five of 16 patients (31{\%}) with ASS had six relatives with a history of collagen diseases, within the second degree of relationship, including two cases of dermatomyositis (vs the non-ASS group, P = 0.018). Patients with ASS more frequently presented with fever and arthralgia, and had elevated levels of C-reactive protein. Nine of the 11 finger lesions (82{\%}) clinically diagnosed as mechanic's hands showed a psoriasiform tissue reaction. ILD was observed in 19 of 20 patients (95{\%}) with ASS, and eight of 21 patients (38{\%}) in the non-ASS group, in which six patients possessed anti-MDA5 antibody. Patients with ASS showed higher serum levels of muscle enzymes, and four of 12 patients (33{\%}) had fasciitis-dominant myopathy, while only one of 11 patients (9{\%}) in the non-ASS group had fasciitis-dominant myopathy. Patients with ASS often present with a psoriasiform tissue reaction in the hand lesions and fasciitis-dominant myopathy, and the relatives of those with ASS are at high risk for collagen diseases.",
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AU - Fukamatsu, Hiroko

AU - Hirai, Yoji

AU - Miyake, Tomoko

AU - Kaji, Tatsuya

AU - Morizane, Shin

AU - Yokoyama, Emi

AU - Hamada, Toshihisa

AU - Oono, Takashi

AU - Koyama, Yoshinobu

AU - Norikane, Seiichiro

AU - Iwatsuki, Keiji

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