Clinical investigation of drug therapy for cases of detrusor hyperactivity with impaired contractile function

Teruhisa Ohashi, Tadasu Takenaka, Sinichi Sako, Katsuyoshi Kondo, Toyohiko Watanabe, Hiromi Kumon

Research output: Contribution to journalArticle

Abstract

We assessed the efficacy and safety of a 1adrenoceptor antagonist (Urapidil) alone or combined with an antimuscarinic (oxybutynin or propiverine) in patients diagnosed with detrusor hyperactivity with impaired contractile function (DHIC). Forty patients with urodynamically proven DHIC were stratified into 2 groups, namely group 1 receiving Urapidil only and group 2 receiving Urapidil plus oxybutynin or propiverine for a 12-week treatment regimen. A total of 40 patients, including 16 in group 1 and 24 in group 2 were treated and 40 (100.0%) completed the 12 weeks of treatment. Significant improvement was noted in both group 1 (75.0%) and group 2 (62.5%) after treatment. Voiding difficulty and urinary urgency improved significantly in all patients of both group 1 and group 2. The results of this study suggest that a i-adrenoceptor antagonist alone or combined with an antimuscarinic represents an effective and relatively safe treatment modality for patients with DHIC.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalNishinihon Journal of Urology
Volume74
Issue number1
Publication statusPublished - Jan 2012

Fingerprint

Drug Therapy
Muscarinic Antagonists
Therapeutics
Adrenergic Receptors
Safety
urapidil
propiverine
oxybutynin

Keywords

  • DHIC
  • Drug therapy

ASJC Scopus subject areas

  • Urology

Cite this

Clinical investigation of drug therapy for cases of detrusor hyperactivity with impaired contractile function. / Ohashi, Teruhisa; Takenaka, Tadasu; Sako, Sinichi; Kondo, Katsuyoshi; Watanabe, Toyohiko; Kumon, Hiromi.

In: Nishinihon Journal of Urology, Vol. 74, No. 1, 01.2012, p. 16-20.

Research output: Contribution to journalArticle

Ohashi, Teruhisa ; Takenaka, Tadasu ; Sako, Sinichi ; Kondo, Katsuyoshi ; Watanabe, Toyohiko ; Kumon, Hiromi. / Clinical investigation of drug therapy for cases of detrusor hyperactivity with impaired contractile function. In: Nishinihon Journal of Urology. 2012 ; Vol. 74, No. 1. pp. 16-20.
@article{e5bc7c3dcf784cc5a9bea6402e045670,
title = "Clinical investigation of drug therapy for cases of detrusor hyperactivity with impaired contractile function",
abstract = "We assessed the efficacy and safety of a 1adrenoceptor antagonist (Urapidil) alone or combined with an antimuscarinic (oxybutynin or propiverine) in patients diagnosed with detrusor hyperactivity with impaired contractile function (DHIC). Forty patients with urodynamically proven DHIC were stratified into 2 groups, namely group 1 receiving Urapidil only and group 2 receiving Urapidil plus oxybutynin or propiverine for a 12-week treatment regimen. A total of 40 patients, including 16 in group 1 and 24 in group 2 were treated and 40 (100.0{\%}) completed the 12 weeks of treatment. Significant improvement was noted in both group 1 (75.0{\%}) and group 2 (62.5{\%}) after treatment. Voiding difficulty and urinary urgency improved significantly in all patients of both group 1 and group 2. The results of this study suggest that a i-adrenoceptor antagonist alone or combined with an antimuscarinic represents an effective and relatively safe treatment modality for patients with DHIC.",
keywords = "DHIC, Drug therapy",
author = "Teruhisa Ohashi and Tadasu Takenaka and Sinichi Sako and Katsuyoshi Kondo and Toyohiko Watanabe and Hiromi Kumon",
year = "2012",
month = "1",
language = "English",
volume = "74",
pages = "16--20",
journal = "Nishinihon Journal of Urology",
issn = "0029-0726",
publisher = "Kyushu University, Faculty of Science",
number = "1",

}

TY - JOUR

T1 - Clinical investigation of drug therapy for cases of detrusor hyperactivity with impaired contractile function

AU - Ohashi, Teruhisa

AU - Takenaka, Tadasu

AU - Sako, Sinichi

AU - Kondo, Katsuyoshi

AU - Watanabe, Toyohiko

AU - Kumon, Hiromi

PY - 2012/1

Y1 - 2012/1

N2 - We assessed the efficacy and safety of a 1adrenoceptor antagonist (Urapidil) alone or combined with an antimuscarinic (oxybutynin or propiverine) in patients diagnosed with detrusor hyperactivity with impaired contractile function (DHIC). Forty patients with urodynamically proven DHIC were stratified into 2 groups, namely group 1 receiving Urapidil only and group 2 receiving Urapidil plus oxybutynin or propiverine for a 12-week treatment regimen. A total of 40 patients, including 16 in group 1 and 24 in group 2 were treated and 40 (100.0%) completed the 12 weeks of treatment. Significant improvement was noted in both group 1 (75.0%) and group 2 (62.5%) after treatment. Voiding difficulty and urinary urgency improved significantly in all patients of both group 1 and group 2. The results of this study suggest that a i-adrenoceptor antagonist alone or combined with an antimuscarinic represents an effective and relatively safe treatment modality for patients with DHIC.

AB - We assessed the efficacy and safety of a 1adrenoceptor antagonist (Urapidil) alone or combined with an antimuscarinic (oxybutynin or propiverine) in patients diagnosed with detrusor hyperactivity with impaired contractile function (DHIC). Forty patients with urodynamically proven DHIC were stratified into 2 groups, namely group 1 receiving Urapidil only and group 2 receiving Urapidil plus oxybutynin or propiverine for a 12-week treatment regimen. A total of 40 patients, including 16 in group 1 and 24 in group 2 were treated and 40 (100.0%) completed the 12 weeks of treatment. Significant improvement was noted in both group 1 (75.0%) and group 2 (62.5%) after treatment. Voiding difficulty and urinary urgency improved significantly in all patients of both group 1 and group 2. The results of this study suggest that a i-adrenoceptor antagonist alone or combined with an antimuscarinic represents an effective and relatively safe treatment modality for patients with DHIC.

KW - DHIC

KW - Drug therapy

UR - http://www.scopus.com/inward/record.url?scp=84863296870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863296870&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84863296870

VL - 74

SP - 16

EP - 20

JO - Nishinihon Journal of Urology

JF - Nishinihon Journal of Urology

SN - 0029-0726

IS - 1

ER -