Clinical implications of the 'no reflow' phenomenon: A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction

Hiroshi Itoh, Atsushi Maruyama, Katsuomi Iwakura, Shin Takiuchi, Tohru Masuyama, Masatsugu Hori, Yorihiko Higashino, Kenshi Fujii, Takazo Minamino

Research output: Contribution to journalArticle

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Abstract

Background: Recent studies demonstrated that the 'no reflow' phenomenon after coronary reflow implies the presence of advanced myocardial damage. In this study, we verified the prognostic value of the detection of this phenomenon by studying complications, left ventricular morphology, and inhospital survival after acute myocardial infarction (AMI). Methods and Results: The study population consisted of 126 patients with a first anterior AMI. All patients received coronary reflow within 24 hours of onset of symptoms and underwent myocardial contrast echocardiography (MCE) before and shortly after coronary reflow with an intracoronary injection of sonicated microbubbles. From contrast reperfusion patterns, patients were divided into two subsets: those with MCE no reflow (47 patients, 37%) and those with MCE reflow (79 patients). There was no difference in the frequency of arrhythmia or coronary events between the two subsets. Pericardial effusion and early congestive heart failure were observed more frequently in patients with MCE no reflow than in those with MCE reflow (26% versus 4%, P

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalCirculation
Volume93
Issue number2
Publication statusPublished - Jan 15 1996
Externally publishedYes

Fingerprint

No-Reflow Phenomenon
Anterior Wall Myocardial Infarction
Ventricular Remodeling
Echocardiography
Myocardial Infarction
Microbubbles
Pericardial Effusion
Reperfusion
Cardiac Arrhythmias
Heart Failure
Injections
Survival
Population

Keywords

  • contrast media
  • echocardiography
  • microcirculation
  • myocardial infarction
  • prognosis
  • remodeling
  • reperfusion

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Clinical implications of the 'no reflow' phenomenon : A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. / Itoh, Hiroshi; Maruyama, Atsushi; Iwakura, Katsuomi; Takiuchi, Shin; Masuyama, Tohru; Hori, Masatsugu; Higashino, Yorihiko; Fujii, Kenshi; Minamino, Takazo.

In: Circulation, Vol. 93, No. 2, 15.01.1996, p. 223-228.

Research output: Contribution to journalArticle

Itoh, H, Maruyama, A, Iwakura, K, Takiuchi, S, Masuyama, T, Hori, M, Higashino, Y, Fujii, K & Minamino, T 1996, 'Clinical implications of the 'no reflow' phenomenon: A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction', Circulation, vol. 93, no. 2, pp. 223-228.
Itoh, Hiroshi ; Maruyama, Atsushi ; Iwakura, Katsuomi ; Takiuchi, Shin ; Masuyama, Tohru ; Hori, Masatsugu ; Higashino, Yorihiko ; Fujii, Kenshi ; Minamino, Takazo. / Clinical implications of the 'no reflow' phenomenon : A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. In: Circulation. 1996 ; Vol. 93, No. 2. pp. 223-228.
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