Clinical features of type 1 autoimmune hepatitis in adolescence and early adulthood

Yasuhiro Miyake, Yoshiaki Iwasaki, Haruhiko Kobashi, Tetsuya Yasunaka, Fusao Ikeda, Akinobu Takaki, Ryoichi Okamoto, Kouichi Takaguchi, Hiroshi Ikeda, Yasuhiro Makino, Kohsaku Sakaguchi, Masaharu Ando, Kazuhide Yamamoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: The peak age of the presentation of autoimmune hepatitis (AIH) is between 40years and 50years. Elderly patients have been reported to have higher frequencies of concurrent thyroid or rheumatic diseases and histological cirrhosis and a lower occurrence of treatment failure. In this study, we assessed the clinical features of Japanese type 1 AIH in adolescence and early adulthood. Methods: Fifteen patients aged ≤ 30years (group 1) were compared with 79 patients aged between 40 years and 50years (group 2). Results: At presentation, patients aged ≤ 30 years accounted for 9% of the study population. Although frequencies of extrahepatic concurrent autoimmune diseases were similar between groups 1 and 2, a tendency toward a lower frequency of concurrent autoimmune thyroiditis was shown in group 1 (0 vs. 18%, P = 0.08). Group 1 had a lower frequency of human leukocyte antigen DR4 (27 vs. 78%, P = 0.002), and histological acute hepatitis was shown more frequently in group 1 (27 vs. 4%, P = 0.002). However, there were no differences in frequencies of the normalization of serum transaminase levels after the introduction of corticosteroid treatment or relapse after the normalization of serum transaminase levels between the two groups. Conclusions: Japanese type 1 AIH patients in adolescence and early adulthood respond well to corticosteroid treatment. However, they may frequently show atypical features, and the diagnosis of type 1 AIH in adolescence and early adulthood may be difficult and should be made carefully.

Original languageEnglish
Pages (from-to)766-771
Number of pages6
JournalHepatology Research
Volume39
Issue number8
DOIs
Publication statusPublished - 2009

Fingerprint

Autoimmune Hepatitis
Transaminases
Adrenal Cortex Hormones
Autoimmune Thyroiditis
Thyroid Diseases
HLA Antigens
Rheumatic Diseases
Treatment Failure
Serum
Hepatitis
Autoimmune Diseases
Fibrosis
Recurrence
Therapeutics
Population

Keywords

  • Acute hepatitis
  • Autoimmune hepatitis
  • Autoimmune thyroiditis
  • Human leukocyte antigen

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

Cite this

Clinical features of type 1 autoimmune hepatitis in adolescence and early adulthood. / Miyake, Yasuhiro; Iwasaki, Yoshiaki; Kobashi, Haruhiko; Yasunaka, Tetsuya; Ikeda, Fusao; Takaki, Akinobu; Okamoto, Ryoichi; Takaguchi, Kouichi; Ikeda, Hiroshi; Makino, Yasuhiro; Sakaguchi, Kohsaku; Ando, Masaharu; Yamamoto, Kazuhide.

In: Hepatology Research, Vol. 39, No. 8, 2009, p. 766-771.

Research output: Contribution to journalArticle

Miyake, Y, Iwasaki, Y, Kobashi, H, Yasunaka, T, Ikeda, F, Takaki, A, Okamoto, R, Takaguchi, K, Ikeda, H, Makino, Y, Sakaguchi, K, Ando, M & Yamamoto, K 2009, 'Clinical features of type 1 autoimmune hepatitis in adolescence and early adulthood', Hepatology Research, vol. 39, no. 8, pp. 766-771. https://doi.org/10.1111/j.1872-034X.2009.00510.x
Miyake, Yasuhiro ; Iwasaki, Yoshiaki ; Kobashi, Haruhiko ; Yasunaka, Tetsuya ; Ikeda, Fusao ; Takaki, Akinobu ; Okamoto, Ryoichi ; Takaguchi, Kouichi ; Ikeda, Hiroshi ; Makino, Yasuhiro ; Sakaguchi, Kohsaku ; Ando, Masaharu ; Yamamoto, Kazuhide. / Clinical features of type 1 autoimmune hepatitis in adolescence and early adulthood. In: Hepatology Research. 2009 ; Vol. 39, No. 8. pp. 766-771.
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AU - Ikeda, Fusao

AU - Takaki, Akinobu

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AU - Ikeda, Hiroshi

AU - Makino, Yasuhiro

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