Clinical features of pancreaticobiliary maljunction: Update analysis of 2nd Japan-nationwide survey

Yuji Morine, Mitsuo Shimada, Hideo Takamatsu, Tatsuo Araida, Itaru Endo, Masayuki Kubota, Akira Toki, Takuo Noda, Toshinobu Matsumura, Shuichi Miyakawa, Hiroki Ishibashi, Terumi Kamisawa, Hiroshi Shimada

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Introduction: Pancreaticobiliary maljunction (PBM) is a congenital anomaly, which can be defined as a union of the pancreatic and biliary ducts located outside off the duodenal wall. We herein investigate clinical features of PBM including as the 2nd report of a Japanese nationwide survey. Patients and methods: During a period of 18 years (from 1990 to 2007), 2,561 patients with PBM were registered at 141 medical institutions in Japan. Among them, eligible patients (n = 2,529) were divided into two groups: adult (n = 1,511) and pediatric patients (n = 1,018). Comparisons of clinical features including associated biliary cancers were performed according to the biliary dilatation (BD), age factor, and time era. Results: Only one case in pediatric patients with BD combined with a bile duct cancer (0.1 %). In adult patients, the bile duct cancer and the gallbladder cancer was seen in 6.9 and 13.4 % patients with BD and in 3.1 and 37.4 % patients without BD, respectively. In adult patients with BD, the occurrence rates of biliary cancers were increased in latter period (00'-07') compared with former period (90'-99'). The ratio of biliary cancer localization was changed between former and latter period, and the bile duct cancer was increased in latter period (from 5.5 to 9.3 %). Conclusions: The largest series of PBM were evaluated to clarify the clinical features including the associated biliary cancer in this Japan-nationwide survey. This report could be widely used in the future as a reference data for diagnosis and treatment of PBM.

Original languageEnglish
Pages (from-to)472-480
Number of pages9
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume20
Issue number5
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

Fingerprint

Japan
Biliary Tract Neoplasms
Dilatation
Bile Duct Neoplasms
Gallbladder Neoplasms
Pediatrics
Surveys and Questionnaires
Pancreatic Ducts
Age Factors

Keywords

  • Amylase level
  • Biliary cancer
  • Biliary dilatation
  • Time era

ASJC Scopus subject areas

  • Hepatology
  • Surgery

Cite this

Clinical features of pancreaticobiliary maljunction : Update analysis of 2nd Japan-nationwide survey. / Morine, Yuji; Shimada, Mitsuo; Takamatsu, Hideo; Araida, Tatsuo; Endo, Itaru; Kubota, Masayuki; Toki, Akira; Noda, Takuo; Matsumura, Toshinobu; Miyakawa, Shuichi; Ishibashi, Hiroki; Kamisawa, Terumi; Shimada, Hiroshi.

In: Journal of Hepato-Biliary-Pancreatic Sciences, Vol. 20, No. 5, 06.2013, p. 472-480.

Research output: Contribution to journalArticle

Morine, Y, Shimada, M, Takamatsu, H, Araida, T, Endo, I, Kubota, M, Toki, A, Noda, T, Matsumura, T, Miyakawa, S, Ishibashi, H, Kamisawa, T & Shimada, H 2013, 'Clinical features of pancreaticobiliary maljunction: Update analysis of 2nd Japan-nationwide survey', Journal of Hepato-Biliary-Pancreatic Sciences, vol. 20, no. 5, pp. 472-480. https://doi.org/10.1007/s00534-013-0606-2
Morine, Yuji ; Shimada, Mitsuo ; Takamatsu, Hideo ; Araida, Tatsuo ; Endo, Itaru ; Kubota, Masayuki ; Toki, Akira ; Noda, Takuo ; Matsumura, Toshinobu ; Miyakawa, Shuichi ; Ishibashi, Hiroki ; Kamisawa, Terumi ; Shimada, Hiroshi. / Clinical features of pancreaticobiliary maljunction : Update analysis of 2nd Japan-nationwide survey. In: Journal of Hepato-Biliary-Pancreatic Sciences. 2013 ; Vol. 20, No. 5. pp. 472-480.
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AU - Morine, Yuji

AU - Shimada, Mitsuo

AU - Takamatsu, Hideo

AU - Araida, Tatsuo

AU - Endo, Itaru

AU - Kubota, Masayuki

AU - Toki, Akira

AU - Noda, Takuo

AU - Matsumura, Toshinobu

AU - Miyakawa, Shuichi

AU - Ishibashi, Hiroki

AU - Kamisawa, Terumi

AU - Shimada, Hiroshi

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N2 - Introduction: Pancreaticobiliary maljunction (PBM) is a congenital anomaly, which can be defined as a union of the pancreatic and biliary ducts located outside off the duodenal wall. We herein investigate clinical features of PBM including as the 2nd report of a Japanese nationwide survey. Patients and methods: During a period of 18 years (from 1990 to 2007), 2,561 patients with PBM were registered at 141 medical institutions in Japan. Among them, eligible patients (n = 2,529) were divided into two groups: adult (n = 1,511) and pediatric patients (n = 1,018). Comparisons of clinical features including associated biliary cancers were performed according to the biliary dilatation (BD), age factor, and time era. Results: Only one case in pediatric patients with BD combined with a bile duct cancer (0.1 %). In adult patients, the bile duct cancer and the gallbladder cancer was seen in 6.9 and 13.4 % patients with BD and in 3.1 and 37.4 % patients without BD, respectively. In adult patients with BD, the occurrence rates of biliary cancers were increased in latter period (00'-07') compared with former period (90'-99'). The ratio of biliary cancer localization was changed between former and latter period, and the bile duct cancer was increased in latter period (from 5.5 to 9.3 %). Conclusions: The largest series of PBM were evaluated to clarify the clinical features including the associated biliary cancer in this Japan-nationwide survey. This report could be widely used in the future as a reference data for diagnosis and treatment of PBM.

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KW - Biliary dilatation

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