Clinical features of non-diabetic renal diseases in patients with type 2 diabetes

Atsuhito Tone, Kenichi Shikata, Mitsuhiro Matsuda, Hitomi Kataoka, Shinichi Okada, Daisuke Ogawa, Jun Wada, Hirofumi Makino

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Although persistent proteinuria is characteristic of diabetic nephropathy (DN), it is important to differentiate non-diabetic renal diseases (NDRD) in diabetic patients with proteinuria. In order to re-evaluate the indications for renal biopsy in the diabetic patients, we retrospectively analyzed the relationship between clinical features and histological diagnosis in 97 Japanese patients with type 2 diabetes manifesting overt proteinuria. Renal biopsy was performed because they were clinically suspected to have NDRD. Patients were divided into three groups according to the histological diagnosis: (1) the DN group (n = 35) had only diabetic lesions, (2) the complicated group (n = 16) had histological changes of NDRD superimposed on DN and (3) the non-DN group (n = 46) had NDRD without diabetic lesions. We evaluated the specificity and sensitivity of four clinical parameters (duration of diabetes, presence or absence of diabetic retinopathy, microscopic hematuria and granular casts as urinary sediments) for the prediction of NDRD. Short duration of diabetes (

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume69
Issue number3
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Type 2 Diabetes Mellitus
Kidney
Diabetic Nephropathies
Proteinuria
Biopsy
Diabetic Retinopathy
Hematuria
Sensitivity and Specificity

Keywords

  • Diabetic nephropathy
  • Diabetic retinopathy
  • Non-diabetic renal disease
  • Renal biopsy
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Clinical features of non-diabetic renal diseases in patients with type 2 diabetes. / Tone, Atsuhito; Shikata, Kenichi; Matsuda, Mitsuhiro; Kataoka, Hitomi; Okada, Shinichi; Ogawa, Daisuke; Wada, Jun; Makino, Hirofumi.

In: Diabetes Research and Clinical Practice, Vol. 69, No. 3, 09.2005, p. 237-242.

Research output: Contribution to journalArticle

@article{b2893917898d4323b5cb859386a0464f,
title = "Clinical features of non-diabetic renal diseases in patients with type 2 diabetes",
abstract = "Although persistent proteinuria is characteristic of diabetic nephropathy (DN), it is important to differentiate non-diabetic renal diseases (NDRD) in diabetic patients with proteinuria. In order to re-evaluate the indications for renal biopsy in the diabetic patients, we retrospectively analyzed the relationship between clinical features and histological diagnosis in 97 Japanese patients with type 2 diabetes manifesting overt proteinuria. Renal biopsy was performed because they were clinically suspected to have NDRD. Patients were divided into three groups according to the histological diagnosis: (1) the DN group (n = 35) had only diabetic lesions, (2) the complicated group (n = 16) had histological changes of NDRD superimposed on DN and (3) the non-DN group (n = 46) had NDRD without diabetic lesions. We evaluated the specificity and sensitivity of four clinical parameters (duration of diabetes, presence or absence of diabetic retinopathy, microscopic hematuria and granular casts as urinary sediments) for the prediction of NDRD. Short duration of diabetes (",
keywords = "Diabetic nephropathy, Diabetic retinopathy, Non-diabetic renal disease, Renal biopsy, Type 2 diabetes mellitus",
author = "Atsuhito Tone and Kenichi Shikata and Mitsuhiro Matsuda and Hitomi Kataoka and Shinichi Okada and Daisuke Ogawa and Jun Wada and Hirofumi Makino",
year = "2005",
month = "9",
doi = "10.1016/j.diabres.2005.02.009",
language = "English",
volume = "69",
pages = "237--242",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Clinical features of non-diabetic renal diseases in patients with type 2 diabetes

AU - Tone, Atsuhito

AU - Shikata, Kenichi

AU - Matsuda, Mitsuhiro

AU - Kataoka, Hitomi

AU - Okada, Shinichi

AU - Ogawa, Daisuke

AU - Wada, Jun

AU - Makino, Hirofumi

PY - 2005/9

Y1 - 2005/9

N2 - Although persistent proteinuria is characteristic of diabetic nephropathy (DN), it is important to differentiate non-diabetic renal diseases (NDRD) in diabetic patients with proteinuria. In order to re-evaluate the indications for renal biopsy in the diabetic patients, we retrospectively analyzed the relationship between clinical features and histological diagnosis in 97 Japanese patients with type 2 diabetes manifesting overt proteinuria. Renal biopsy was performed because they were clinically suspected to have NDRD. Patients were divided into three groups according to the histological diagnosis: (1) the DN group (n = 35) had only diabetic lesions, (2) the complicated group (n = 16) had histological changes of NDRD superimposed on DN and (3) the non-DN group (n = 46) had NDRD without diabetic lesions. We evaluated the specificity and sensitivity of four clinical parameters (duration of diabetes, presence or absence of diabetic retinopathy, microscopic hematuria and granular casts as urinary sediments) for the prediction of NDRD. Short duration of diabetes (

AB - Although persistent proteinuria is characteristic of diabetic nephropathy (DN), it is important to differentiate non-diabetic renal diseases (NDRD) in diabetic patients with proteinuria. In order to re-evaluate the indications for renal biopsy in the diabetic patients, we retrospectively analyzed the relationship between clinical features and histological diagnosis in 97 Japanese patients with type 2 diabetes manifesting overt proteinuria. Renal biopsy was performed because they were clinically suspected to have NDRD. Patients were divided into three groups according to the histological diagnosis: (1) the DN group (n = 35) had only diabetic lesions, (2) the complicated group (n = 16) had histological changes of NDRD superimposed on DN and (3) the non-DN group (n = 46) had NDRD without diabetic lesions. We evaluated the specificity and sensitivity of four clinical parameters (duration of diabetes, presence or absence of diabetic retinopathy, microscopic hematuria and granular casts as urinary sediments) for the prediction of NDRD. Short duration of diabetes (

KW - Diabetic nephropathy

KW - Diabetic retinopathy

KW - Non-diabetic renal disease

KW - Renal biopsy

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=23744472597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744472597&partnerID=8YFLogxK

U2 - 10.1016/j.diabres.2005.02.009

DO - 10.1016/j.diabres.2005.02.009

M3 - Article

C2 - 16098920

AN - SCOPUS:23744472597

VL - 69

SP - 237

EP - 242

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 3

ER -