Clinical features of adult patients with acute lymphocytic leukemia according to immunological phenotypes of lymphoblasts

K. Kawashima, K. Yamada, Y. Morishima, Y. Kato, E. Watanabe, H. Suzuki, H. Takeyama, M. Kobayashi, K. Ogata, J. Takamatsu, S. Minami, M. Tanimoto, S. Yoshikawa, T. Naoe, K. Naito, H. Yamaguchi, Y. Morishita, M. Ogura, H. Yamada

Research output: Contribution to journalArticle

Abstract

An immunological classification of adult acute lymphocytic leukemia (ALL) to three main subgroups appears to be of important value since some evaluation has been established between a phenotype of leukemic cells and clinical features. We investigated the immunological phenotypes on bone marrow and/or peripheral blood lymphoblasts for 27 adult patients with ALL. Spontaneous rosette formation with sheep erythrocytes (E-rosettes) was identified as T cell and the presence of complement receptor for C3 (EAC-rosettes) identified as B cell. The median age of patients with T-cell (5 cases), B-cell (5 cases) and null-cell ALL (17 cases) was 48, 18 and 31 years, respectively. Morphologically, leukemic cells from T-cell ALL patients very often revealed indented, folded nucleus characteristic of adult T-cell leukemia proposed by Uchiyama et al.. With respect to their clinical features, there were differences noted in the number of patients with organomegaly and high peripheral white blood cell counts. Very commonly, patients with T-cell and B-cell ALL had massive leukemic infiltration, compared with those with null-cell ALL. Of interest is the correlation between this immunological classification and the prognosis, since T-cell and B-cell ALL were associated with a poorer prognosis than null-cell ALL, in terms of the median length of first complete remission and median survival. This poorer prognosis in adult patients with T-cell and B-cell ALL would provide useful information for selecting differing forms of therapy.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalActa Haematologica Japonica
Volume42
Issue number3
Publication statusPublished - 1979
Externally publishedYes

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Phenotype
B-Cell Leukemia
Null Lymphocytes
T-Lymphocytes
B-Lymphocytes
Leukemic Infiltration
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Rosette Formation
Complement Receptors
Adult T Cell Leukemia Lymphoma
Complement C3
Leukocyte Count
Sheep
Erythrocytes
Bone Marrow
Survival

ASJC Scopus subject areas

  • Hematology

Cite this

Kawashima, K., Yamada, K., Morishima, Y., Kato, Y., Watanabe, E., Suzuki, H., ... Yamada, H. (1979). Clinical features of adult patients with acute lymphocytic leukemia according to immunological phenotypes of lymphoblasts. Acta Haematologica Japonica, 42(3), 399-405.

Clinical features of adult patients with acute lymphocytic leukemia according to immunological phenotypes of lymphoblasts. / Kawashima, K.; Yamada, K.; Morishima, Y.; Kato, Y.; Watanabe, E.; Suzuki, H.; Takeyama, H.; Kobayashi, M.; Ogata, K.; Takamatsu, J.; Minami, S.; Tanimoto, M.; Yoshikawa, S.; Naoe, T.; Naito, K.; Yamaguchi, H.; Morishita, Y.; Ogura, M.; Yamada, H.

In: Acta Haematologica Japonica, Vol. 42, No. 3, 1979, p. 399-405.

Research output: Contribution to journalArticle

Kawashima, K, Yamada, K, Morishima, Y, Kato, Y, Watanabe, E, Suzuki, H, Takeyama, H, Kobayashi, M, Ogata, K, Takamatsu, J, Minami, S, Tanimoto, M, Yoshikawa, S, Naoe, T, Naito, K, Yamaguchi, H, Morishita, Y, Ogura, M & Yamada, H 1979, 'Clinical features of adult patients with acute lymphocytic leukemia according to immunological phenotypes of lymphoblasts', Acta Haematologica Japonica, vol. 42, no. 3, pp. 399-405.
Kawashima, K. ; Yamada, K. ; Morishima, Y. ; Kato, Y. ; Watanabe, E. ; Suzuki, H. ; Takeyama, H. ; Kobayashi, M. ; Ogata, K. ; Takamatsu, J. ; Minami, S. ; Tanimoto, M. ; Yoshikawa, S. ; Naoe, T. ; Naito, K. ; Yamaguchi, H. ; Morishita, Y. ; Ogura, M. ; Yamada, H. / Clinical features of adult patients with acute lymphocytic leukemia according to immunological phenotypes of lymphoblasts. In: Acta Haematologica Japonica. 1979 ; Vol. 42, No. 3. pp. 399-405.
@article{0c363bf598bf48008e31032568a0116d,
title = "Clinical features of adult patients with acute lymphocytic leukemia according to immunological phenotypes of lymphoblasts",
abstract = "An immunological classification of adult acute lymphocytic leukemia (ALL) to three main subgroups appears to be of important value since some evaluation has been established between a phenotype of leukemic cells and clinical features. We investigated the immunological phenotypes on bone marrow and/or peripheral blood lymphoblasts for 27 adult patients with ALL. Spontaneous rosette formation with sheep erythrocytes (E-rosettes) was identified as T cell and the presence of complement receptor for C3 (EAC-rosettes) identified as B cell. The median age of patients with T-cell (5 cases), B-cell (5 cases) and null-cell ALL (17 cases) was 48, 18 and 31 years, respectively. Morphologically, leukemic cells from T-cell ALL patients very often revealed indented, folded nucleus characteristic of adult T-cell leukemia proposed by Uchiyama et al.. With respect to their clinical features, there were differences noted in the number of patients with organomegaly and high peripheral white blood cell counts. Very commonly, patients with T-cell and B-cell ALL had massive leukemic infiltration, compared with those with null-cell ALL. Of interest is the correlation between this immunological classification and the prognosis, since T-cell and B-cell ALL were associated with a poorer prognosis than null-cell ALL, in terms of the median length of first complete remission and median survival. This poorer prognosis in adult patients with T-cell and B-cell ALL would provide useful information for selecting differing forms of therapy.",
author = "K. Kawashima and K. Yamada and Y. Morishima and Y. Kato and E. Watanabe and H. Suzuki and H. Takeyama and M. Kobayashi and K. Ogata and J. Takamatsu and S. Minami and M. Tanimoto and S. Yoshikawa and T. Naoe and K. Naito and H. Yamaguchi and Y. Morishita and M. Ogura and H. Yamada",
year = "1979",
language = "English",
volume = "42",
pages = "399--405",
journal = "International Journal of Hematology",
issn = "0925-5710",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Clinical features of adult patients with acute lymphocytic leukemia according to immunological phenotypes of lymphoblasts

AU - Kawashima, K.

AU - Yamada, K.

AU - Morishima, Y.

AU - Kato, Y.

AU - Watanabe, E.

AU - Suzuki, H.

AU - Takeyama, H.

AU - Kobayashi, M.

AU - Ogata, K.

AU - Takamatsu, J.

AU - Minami, S.

AU - Tanimoto, M.

AU - Yoshikawa, S.

AU - Naoe, T.

AU - Naito, K.

AU - Yamaguchi, H.

AU - Morishita, Y.

AU - Ogura, M.

AU - Yamada, H.

PY - 1979

Y1 - 1979

N2 - An immunological classification of adult acute lymphocytic leukemia (ALL) to three main subgroups appears to be of important value since some evaluation has been established between a phenotype of leukemic cells and clinical features. We investigated the immunological phenotypes on bone marrow and/or peripheral blood lymphoblasts for 27 adult patients with ALL. Spontaneous rosette formation with sheep erythrocytes (E-rosettes) was identified as T cell and the presence of complement receptor for C3 (EAC-rosettes) identified as B cell. The median age of patients with T-cell (5 cases), B-cell (5 cases) and null-cell ALL (17 cases) was 48, 18 and 31 years, respectively. Morphologically, leukemic cells from T-cell ALL patients very often revealed indented, folded nucleus characteristic of adult T-cell leukemia proposed by Uchiyama et al.. With respect to their clinical features, there were differences noted in the number of patients with organomegaly and high peripheral white blood cell counts. Very commonly, patients with T-cell and B-cell ALL had massive leukemic infiltration, compared with those with null-cell ALL. Of interest is the correlation between this immunological classification and the prognosis, since T-cell and B-cell ALL were associated with a poorer prognosis than null-cell ALL, in terms of the median length of first complete remission and median survival. This poorer prognosis in adult patients with T-cell and B-cell ALL would provide useful information for selecting differing forms of therapy.

AB - An immunological classification of adult acute lymphocytic leukemia (ALL) to three main subgroups appears to be of important value since some evaluation has been established between a phenotype of leukemic cells and clinical features. We investigated the immunological phenotypes on bone marrow and/or peripheral blood lymphoblasts for 27 adult patients with ALL. Spontaneous rosette formation with sheep erythrocytes (E-rosettes) was identified as T cell and the presence of complement receptor for C3 (EAC-rosettes) identified as B cell. The median age of patients with T-cell (5 cases), B-cell (5 cases) and null-cell ALL (17 cases) was 48, 18 and 31 years, respectively. Morphologically, leukemic cells from T-cell ALL patients very often revealed indented, folded nucleus characteristic of adult T-cell leukemia proposed by Uchiyama et al.. With respect to their clinical features, there were differences noted in the number of patients with organomegaly and high peripheral white blood cell counts. Very commonly, patients with T-cell and B-cell ALL had massive leukemic infiltration, compared with those with null-cell ALL. Of interest is the correlation between this immunological classification and the prognosis, since T-cell and B-cell ALL were associated with a poorer prognosis than null-cell ALL, in terms of the median length of first complete remission and median survival. This poorer prognosis in adult patients with T-cell and B-cell ALL would provide useful information for selecting differing forms of therapy.

UR - http://www.scopus.com/inward/record.url?scp=0018750363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018750363&partnerID=8YFLogxK

M3 - Article

C2 - 315147

AN - SCOPUS:0018750363

VL - 42

SP - 399

EP - 405

JO - International Journal of Hematology

JF - International Journal of Hematology

SN - 0925-5710

IS - 3

ER -