Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan: First report of the pediatric rheumatology association of Japan (PRAJ)

Junko Yasumura, Masato Yashiro, Nami Okamoto, Kosuke Shabana, Hiroaki Umebayashi, Naomi Iwata, Yuka Okura, Tomohiro Kubota, Masaki Shimizu, Minako Tomiita, Yasuo Nakagishi, Kenichi Nishimura, Ryoki Hara, Mao Mizuta, Takahiro Yasumi, Fumiya Yamaide, Hiroyuki Wakiguchi, Masao Kobayashi, Masaaki Mori

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Although there are many reports on Juvenile Idiopathic arthritis-associated uveitis (JIA-U) from various countries, especially from Europe and North America, there are few reports from Asia. Our aim was to investigate the epidemiology, characteristics and predictors of JIA-U in Japan. Methods: Data were retrospectively collected on 726 patients with JIA from medical records as of April 2016 at 15 medical centers specialized in pediatric rheumatic diseases. Of these, patients with uveitis were further investigated for the specific characteristics of this manifestation. Results: The prevalence of uveitis was 6.1% in the 726 JIA patients examined. Incidence of uveitis was significantly higher in patients with an earlier arthritis onset (2.6-vs.-5.8 years, P < 0.0001), oligoarthritis (16.1%-vs.-1.6%, P < 0.001), or anti-nuclear antibodies. On the contrary, it was significantly less common in patients with rheumatoid factor or anti-cyclic citrullinated peptide antibodies. A history of using methotrexate (MTX), infliximab or adalimumab was also associated with uveitis occurrence. The median age at uveitis diagnosis was 5 years, and the median time from arthritis onset to uveitis diagnosis was 2 years. The occurrence of anterior and bilateral uveitis was 79.3 and 53.7%, respectively. There were no symptoms at uveitis diagnosis in 58.5% of cases. Complications arising between the time of uveitis diagnosis and the last observation increased from 31.7 to 56.1%; in particular, cataract was increased 3-fold. While no patients lost their vision, 61.9% did not recover normal vision (≥ 1.0), and in many cases active uveitis persisted, especially in males. In addition to steroid eye drops (97.6%) and MTX (15.4%), biological agents were used for treating the uveitis in 41.5% of patients. Conclusions: The epidemiology, characteristics and predictors of JIA-U in Japan are described here for the first time. Although the prevalence of JIA-U in Japan is lower than in predominantly Caucasian cohorts, as reported from North America and Europe, the epidemiology, characteristics and predictors were found to be similar.

Original languageEnglish
Article number15
JournalPediatric Rheumatology
Volume17
Issue number1
DOIs
Publication statusPublished - Apr 11 2019

Fingerprint

Juvenile Arthritis
Uveitis
Rheumatology
Japan
Pediatrics
Epidemiology
North America
Methotrexate
Arthritis
Anterior Uveitis
Ophthalmic Solutions
Rheumatoid Factor
Biological Factors
Rheumatic Diseases
Cataract
Medical Records
Anti-Idiotypic Antibodies

Keywords

  • Asian
  • Epidemiology
  • Juvenile idiopathic arthritis
  • Uveitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Rheumatology
  • Immunology and Allergy

Cite this

Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan : First report of the pediatric rheumatology association of Japan (PRAJ). / Yasumura, Junko; Yashiro, Masato; Okamoto, Nami; Shabana, Kosuke; Umebayashi, Hiroaki; Iwata, Naomi; Okura, Yuka; Kubota, Tomohiro; Shimizu, Masaki; Tomiita, Minako; Nakagishi, Yasuo; Nishimura, Kenichi; Hara, Ryoki; Mizuta, Mao; Yasumi, Takahiro; Yamaide, Fumiya; Wakiguchi, Hiroyuki; Kobayashi, Masao; Mori, Masaaki.

In: Pediatric Rheumatology, Vol. 17, No. 1, 15, 11.04.2019.

Research output: Contribution to journalArticle

Yasumura, J, Yashiro, M, Okamoto, N, Shabana, K, Umebayashi, H, Iwata, N, Okura, Y, Kubota, T, Shimizu, M, Tomiita, M, Nakagishi, Y, Nishimura, K, Hara, R, Mizuta, M, Yasumi, T, Yamaide, F, Wakiguchi, H, Kobayashi, M & Mori, M 2019, 'Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan: First report of the pediatric rheumatology association of Japan (PRAJ)', Pediatric Rheumatology, vol. 17, no. 1, 15. https://doi.org/10.1186/s12969-019-0318-5
Yasumura, Junko ; Yashiro, Masato ; Okamoto, Nami ; Shabana, Kosuke ; Umebayashi, Hiroaki ; Iwata, Naomi ; Okura, Yuka ; Kubota, Tomohiro ; Shimizu, Masaki ; Tomiita, Minako ; Nakagishi, Yasuo ; Nishimura, Kenichi ; Hara, Ryoki ; Mizuta, Mao ; Yasumi, Takahiro ; Yamaide, Fumiya ; Wakiguchi, Hiroyuki ; Kobayashi, Masao ; Mori, Masaaki. / Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan : First report of the pediatric rheumatology association of Japan (PRAJ). In: Pediatric Rheumatology. 2019 ; Vol. 17, No. 1.
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title = "Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan: First report of the pediatric rheumatology association of Japan (PRAJ)",
abstract = "Background: Although there are many reports on Juvenile Idiopathic arthritis-associated uveitis (JIA-U) from various countries, especially from Europe and North America, there are few reports from Asia. Our aim was to investigate the epidemiology, characteristics and predictors of JIA-U in Japan. Methods: Data were retrospectively collected on 726 patients with JIA from medical records as of April 2016 at 15 medical centers specialized in pediatric rheumatic diseases. Of these, patients with uveitis were further investigated for the specific characteristics of this manifestation. Results: The prevalence of uveitis was 6.1{\%} in the 726 JIA patients examined. Incidence of uveitis was significantly higher in patients with an earlier arthritis onset (2.6-vs.-5.8 years, P < 0.0001), oligoarthritis (16.1{\%}-vs.-1.6{\%}, P < 0.001), or anti-nuclear antibodies. On the contrary, it was significantly less common in patients with rheumatoid factor or anti-cyclic citrullinated peptide antibodies. A history of using methotrexate (MTX), infliximab or adalimumab was also associated with uveitis occurrence. The median age at uveitis diagnosis was 5 years, and the median time from arthritis onset to uveitis diagnosis was 2 years. The occurrence of anterior and bilateral uveitis was 79.3 and 53.7{\%}, respectively. There were no symptoms at uveitis diagnosis in 58.5{\%} of cases. Complications arising between the time of uveitis diagnosis and the last observation increased from 31.7 to 56.1{\%}; in particular, cataract was increased 3-fold. While no patients lost their vision, 61.9{\%} did not recover normal vision (≥ 1.0), and in many cases active uveitis persisted, especially in males. In addition to steroid eye drops (97.6{\%}) and MTX (15.4{\%}), biological agents were used for treating the uveitis in 41.5{\%} of patients. Conclusions: The epidemiology, characteristics and predictors of JIA-U in Japan are described here for the first time. Although the prevalence of JIA-U in Japan is lower than in predominantly Caucasian cohorts, as reported from North America and Europe, the epidemiology, characteristics and predictors were found to be similar.",
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T1 - Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan

T2 - First report of the pediatric rheumatology association of Japan (PRAJ)

AU - Yasumura, Junko

AU - Yashiro, Masato

AU - Okamoto, Nami

AU - Shabana, Kosuke

AU - Umebayashi, Hiroaki

AU - Iwata, Naomi

AU - Okura, Yuka

AU - Kubota, Tomohiro

AU - Shimizu, Masaki

AU - Tomiita, Minako

AU - Nakagishi, Yasuo

AU - Nishimura, Kenichi

AU - Hara, Ryoki

AU - Mizuta, Mao

AU - Yasumi, Takahiro

AU - Yamaide, Fumiya

AU - Wakiguchi, Hiroyuki

AU - Kobayashi, Masao

AU - Mori, Masaaki

PY - 2019/4/11

Y1 - 2019/4/11

N2 - Background: Although there are many reports on Juvenile Idiopathic arthritis-associated uveitis (JIA-U) from various countries, especially from Europe and North America, there are few reports from Asia. Our aim was to investigate the epidemiology, characteristics and predictors of JIA-U in Japan. Methods: Data were retrospectively collected on 726 patients with JIA from medical records as of April 2016 at 15 medical centers specialized in pediatric rheumatic diseases. Of these, patients with uveitis were further investigated for the specific characteristics of this manifestation. Results: The prevalence of uveitis was 6.1% in the 726 JIA patients examined. Incidence of uveitis was significantly higher in patients with an earlier arthritis onset (2.6-vs.-5.8 years, P < 0.0001), oligoarthritis (16.1%-vs.-1.6%, P < 0.001), or anti-nuclear antibodies. On the contrary, it was significantly less common in patients with rheumatoid factor or anti-cyclic citrullinated peptide antibodies. A history of using methotrexate (MTX), infliximab or adalimumab was also associated with uveitis occurrence. The median age at uveitis diagnosis was 5 years, and the median time from arthritis onset to uveitis diagnosis was 2 years. The occurrence of anterior and bilateral uveitis was 79.3 and 53.7%, respectively. There were no symptoms at uveitis diagnosis in 58.5% of cases. Complications arising between the time of uveitis diagnosis and the last observation increased from 31.7 to 56.1%; in particular, cataract was increased 3-fold. While no patients lost their vision, 61.9% did not recover normal vision (≥ 1.0), and in many cases active uveitis persisted, especially in males. In addition to steroid eye drops (97.6%) and MTX (15.4%), biological agents were used for treating the uveitis in 41.5% of patients. Conclusions: The epidemiology, characteristics and predictors of JIA-U in Japan are described here for the first time. Although the prevalence of JIA-U in Japan is lower than in predominantly Caucasian cohorts, as reported from North America and Europe, the epidemiology, characteristics and predictors were found to be similar.

AB - Background: Although there are many reports on Juvenile Idiopathic arthritis-associated uveitis (JIA-U) from various countries, especially from Europe and North America, there are few reports from Asia. Our aim was to investigate the epidemiology, characteristics and predictors of JIA-U in Japan. Methods: Data were retrospectively collected on 726 patients with JIA from medical records as of April 2016 at 15 medical centers specialized in pediatric rheumatic diseases. Of these, patients with uveitis were further investigated for the specific characteristics of this manifestation. Results: The prevalence of uveitis was 6.1% in the 726 JIA patients examined. Incidence of uveitis was significantly higher in patients with an earlier arthritis onset (2.6-vs.-5.8 years, P < 0.0001), oligoarthritis (16.1%-vs.-1.6%, P < 0.001), or anti-nuclear antibodies. On the contrary, it was significantly less common in patients with rheumatoid factor or anti-cyclic citrullinated peptide antibodies. A history of using methotrexate (MTX), infliximab or adalimumab was also associated with uveitis occurrence. The median age at uveitis diagnosis was 5 years, and the median time from arthritis onset to uveitis diagnosis was 2 years. The occurrence of anterior and bilateral uveitis was 79.3 and 53.7%, respectively. There were no symptoms at uveitis diagnosis in 58.5% of cases. Complications arising between the time of uveitis diagnosis and the last observation increased from 31.7 to 56.1%; in particular, cataract was increased 3-fold. While no patients lost their vision, 61.9% did not recover normal vision (≥ 1.0), and in many cases active uveitis persisted, especially in males. In addition to steroid eye drops (97.6%) and MTX (15.4%), biological agents were used for treating the uveitis in 41.5% of patients. Conclusions: The epidemiology, characteristics and predictors of JIA-U in Japan are described here for the first time. Although the prevalence of JIA-U in Japan is lower than in predominantly Caucasian cohorts, as reported from North America and Europe, the epidemiology, characteristics and predictors were found to be similar.

KW - Asian

KW - Epidemiology

KW - Juvenile idiopathic arthritis

KW - Uveitis

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