TY - JOUR
T1 - Clinical factors that impair health-related quality of life in ulcerative colitis patients vary with the disease duration
AU - Kuriyama, Motoaki
AU - Kato, Jun
AU - Kuwaki, Kenji
AU - Morimoto, Naofumi
AU - Nawa, Toru
AU - Fujimoto, Tsuyoshi
AU - Kono, Hiroyuki
AU - Okano, Nobuaki
AU - Miyaike, Jiro
AU - Morita, Takechiyo
AU - Okada, Hiroyuki
AU - Suzuki, Seiyuu
AU - Yoshioka, Toshifumi
AU - Shiode, Junji
AU - Suwaki, Kinichiro
AU - Sakaguchi, Kohsaku
AU - Shiratori, Yasushi
PY - 2008/7
Y1 - 2008/7
N2 - Background: and aim The health-related quality of life (HRQOL) of patients with ulcerative colitis (UC) can be impaired because of the chronic symptoms. Although UC patients suffer from such symptoms over the long term, there have been few reports on the changes of HRQOL with disease duration. The aim of this study was to clarify these changes. Methods: The HRQOL of 331 Japanese UC patients was examined using the validated Japanese version of the Inflammatory Bowel Disease Questionnaire (J-IBDQ). HRQOL and factors affecting HRQOL identified using multiple linear regression analysis were stratified by disease duration. Results: Of the 15 clinical factors examined, the clinical activity index score was the strongest determinant (P<0.0001) of all the scores of IBDQ regardless of disease duration. HRQOL did not differ significantly among patients with different disease durations. The factors, however, that affected HRQOL varied according to disease duration. In patients with disease duration of less than 5 years, the clinical activity index score was the predominant factor affecting HRQOL. Being 'on sick leave or hospitalized' was a significant factor impairing HRQOL in patients with disease duration of 5-9 years. Moreover, complications due to corticosteroids significantly impaired all of the IBDQ scores in patients with disease duration of 10 years or more. Conclusion: Factors that affected the HRQOL of UC patients varied according to the patients' disease duration. Our findings should assist in the development of a long-term strategy for the treatment of UC patients.
AB - Background: and aim The health-related quality of life (HRQOL) of patients with ulcerative colitis (UC) can be impaired because of the chronic symptoms. Although UC patients suffer from such symptoms over the long term, there have been few reports on the changes of HRQOL with disease duration. The aim of this study was to clarify these changes. Methods: The HRQOL of 331 Japanese UC patients was examined using the validated Japanese version of the Inflammatory Bowel Disease Questionnaire (J-IBDQ). HRQOL and factors affecting HRQOL identified using multiple linear regression analysis were stratified by disease duration. Results: Of the 15 clinical factors examined, the clinical activity index score was the strongest determinant (P<0.0001) of all the scores of IBDQ regardless of disease duration. HRQOL did not differ significantly among patients with different disease durations. The factors, however, that affected HRQOL varied according to disease duration. In patients with disease duration of less than 5 years, the clinical activity index score was the predominant factor affecting HRQOL. Being 'on sick leave or hospitalized' was a significant factor impairing HRQOL in patients with disease duration of 5-9 years. Moreover, complications due to corticosteroids significantly impaired all of the IBDQ scores in patients with disease duration of 10 years or more. Conclusion: Factors that affected the HRQOL of UC patients varied according to the patients' disease duration. Our findings should assist in the development of a long-term strategy for the treatment of UC patients.
KW - Corticosteroids
KW - Disease duration
KW - Health-related quality of life
KW - Inflammatory bowel disease
KW - Ulcerative colitis
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U2 - 10.1097/MEG.0b013e3282f5e9c9
DO - 10.1097/MEG.0b013e3282f5e9c9
M3 - Article
C2 - 18679065
AN - SCOPUS:62149120696
VL - 20
SP - 634
EP - 641
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 7
ER -