Clinical factors that impair health-related quality of life in ulcerative colitis patients vary with the disease duration

Motoaki Kuriyama, Jun Kato, Kenji Kuwaki, Naofumi Morimoto, Toru Nawa, Tsuyoshi Fujimoto, Hiroyuki Kono, Nobuaki Okano, Jiro Miyaike, Takechiyo Morita, Hiroyuki Okada, Seiyuu Suzuki, Toshifumi Yoshioka, Junji Shiode, Kinichiro Suwaki, Kohsaku Sakaguchi, Yasushi Shiratori

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: and aim The health-related quality of life (HRQOL) of patients with ulcerative colitis (UC) can be impaired because of the chronic symptoms. Although UC patients suffer from such symptoms over the long term, there have been few reports on the changes of HRQOL with disease duration. The aim of this study was to clarify these changes. Methods: The HRQOL of 331 Japanese UC patients was examined using the validated Japanese version of the Inflammatory Bowel Disease Questionnaire (J-IBDQ). HRQOL and factors affecting HRQOL identified using multiple linear regression analysis were stratified by disease duration. Results: Of the 15 clinical factors examined, the clinical activity index score was the strongest determinant (P<0.0001) of all the scores of IBDQ regardless of disease duration. HRQOL did not differ significantly among patients with different disease durations. The factors, however, that affected HRQOL varied according to disease duration. In patients with disease duration of less than 5 years, the clinical activity index score was the predominant factor affecting HRQOL. Being 'on sick leave or hospitalized' was a significant factor impairing HRQOL in patients with disease duration of 5-9 years. Moreover, complications due to corticosteroids significantly impaired all of the IBDQ scores in patients with disease duration of 10 years or more. Conclusion: Factors that affected the HRQOL of UC patients varied according to the patients' disease duration. Our findings should assist in the development of a long-term strategy for the treatment of UC patients.

Original languageEnglish
Pages (from-to)634-641
Number of pages8
JournalEuropean Journal of Gastroenterology and Hepatology
Volume20
Issue number7
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Corticosteroids
  • Disease duration
  • Health-related quality of life
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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  • Cite this

    Kuriyama, M., Kato, J., Kuwaki, K., Morimoto, N., Nawa, T., Fujimoto, T., Kono, H., Okano, N., Miyaike, J., Morita, T., Okada, H., Suzuki, S., Yoshioka, T., Shiode, J., Suwaki, K., Sakaguchi, K., & Shiratori, Y. (2008). Clinical factors that impair health-related quality of life in ulcerative colitis patients vary with the disease duration. European Journal of Gastroenterology and Hepatology, 20(7), 634-641. https://doi.org/10.1097/MEG.0b013e3282f5e9c9