Clinical experience of long-term transdermal treatment with nitric oxide donor for women with preeclampsia

Mikiya Nakatsuka, Katsuhiko Tada, Yoshihiro Kimura, Kazuo Asagiri, Yasuhiko Kamada, Masayo Takata, Takakimi Nakata, Nanako Inoue, Takafumi Kudo

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


Isosorbide dinitrate (ISDN), a nitric oxide donor, was applied transdermally for 4-16 days to 4 preeclamptic women with oligohydramnios, intrauterine fetal growth retardation (IUGR), and elevated resistance of blood flow in the uterine arteries. Pulsed Doppler ultrasonography revealed immediate and drastic improvement of pulsatility index (PI) of uterine arteries following treatment with ISDN. The average PI in uterine arteries of the 4 patients was reduced to approximately 67% of that of the untreated state. In 2 patients the amniotic fluid gradually increased over a few days which suggested improvement of fetoplacental circulation during administration of ISDN. This study suggests that long-term transdermal ISDN is an effective therapy, at least in a portion of preeclamptic women, to avoid maternal hypertension, fetal distress, oligohydramnios, and IUGR, and consequentially to prolong the gestational period.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalGynecologic and Obstetric Investigation
Issue number1
Publication statusPublished - Jan 20 1999


  • Nitric oxide
  • Oligohydramnios
  • Preeclampsia
  • Pregnancy
  • Ultrasonography
  • Uterine arteries

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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