TY - JOUR
T1 - Clinical evalution of cefpirome for severe infections in patients with hematological diseuse tokai infection study- on hematological disorders
AU - Maruyama, Humio
AU - Tanimoto, Mitsune
AU - Hotta, Tomomitsu
AU - Morishima, Yasuo
AU - Nitta, Masakazu
AU - Oguri, Takashi
AU - Tanaka, Masao
AU - Takeyama, Hideo
AU - Shimizu, Kazuyuki
AU - Murase, Takuhide
AU - Yokomaku, Shozo
AU - Ichikawa, Atsushi
AU - Ohno, Rhuzo
AU - Hirano, Masami
AU - Shirakawa, Shigeru
AU - Saito, Hidehiko
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - A prospective study was carried out to evaluate the efficacy and safety of cefpirome (CPR) in treating infections associated with hematological diseases. 1) CPR was administered alone to one hundred patients in the study, and 77 of them were evaluted for efficacy. 2) CPR was effective or markedly effective in 45 of the 77 patients (efficacy rates 58.4 %). In septicemia and suspected septicemia, the efficacy rates were 25% (1/4) and 59.7% (37/62), respectively. 3) The efficacy rate depended on the neutrophil count before and after antimicrobial treatment. As the counts increased, the efficacys rates rose. 4) In patients with a neutrophil count under 500/yt/l before CPR administration and over 500 μ1 after CPR, the efficacy rates for treatment with CPR alone and in combination with G-CSF were 25% (1/4) and 80.0% (8/10), respectively. The efficacy rates were higher in patients receiving CPR plus G-CSF, suggesting that G-CSF is likely to be of value in the treatment of infections. 5) Adverse effects of CPR in the 100 patients consisted of nausea in one patient (1.0%) and abdonormal laboratory values (mainly elevation of GOT, GPT and AL-P) in 11 patients. None of the adverse effects were serious and all resolved after completion of treatment with CPR.
AB - A prospective study was carried out to evaluate the efficacy and safety of cefpirome (CPR) in treating infections associated with hematological diseases. 1) CPR was administered alone to one hundred patients in the study, and 77 of them were evaluted for efficacy. 2) CPR was effective or markedly effective in 45 of the 77 patients (efficacy rates 58.4 %). In septicemia and suspected septicemia, the efficacy rates were 25% (1/4) and 59.7% (37/62), respectively. 3) The efficacy rate depended on the neutrophil count before and after antimicrobial treatment. As the counts increased, the efficacys rates rose. 4) In patients with a neutrophil count under 500/yt/l before CPR administration and over 500 μ1 after CPR, the efficacy rates for treatment with CPR alone and in combination with G-CSF were 25% (1/4) and 80.0% (8/10), respectively. The efficacy rates were higher in patients receiving CPR plus G-CSF, suggesting that G-CSF is likely to be of value in the treatment of infections. 5) Adverse effects of CPR in the 100 patients consisted of nausea in one patient (1.0%) and abdonormal laboratory values (mainly elevation of GOT, GPT and AL-P) in 11 patients. None of the adverse effects were serious and all resolved after completion of treatment with CPR.
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M3 - Article
AN - SCOPUS:33744760255
VL - 45
SP - 498
EP - 499
JO - Japanese Journal of Chemotherapy
JF - Japanese Journal of Chemotherapy
SN - 1340-7007
IS - 7
ER -