Abstract
Serum and bronchoalveolar lavage fluid levels of several tumor markers were measured in 71 patients with lung cancer, 36 patients with benign lung diseases and 100 healthy controls. The mean level and the positive rate of serum carcinoembryonic antigen (CEA) in patients with lung cancer (10.9 ng/ml, 43.7%) were statistically higher than those in patients with benign lung diseases (1.6 ng/ml, 8.3%). The mean level and the positive rate of serum neuron-specific-enolase (NSE) in patients with lung cancer (14.8 ng/ml, 45.1%) were statistically higher than those in patients with benign lung diseases (6.5 ng/ml, 11.1%), and patients with small cell carcinoma showed the higher mean level and higher positive rate of serum NSE compared to patients with other histologic types of lung cancer. Serum levels of ferritin, β2-microglobulin (β2MG), immunosuppressive acidic protein and tissue polypeptide antigen showed poor diagnostic values. The mean levels of bronchoalveolar lavage fluid CEA, ferritin and β2MG in patients with lung cancer were statistically higher than those in patients with benign lung disease and healthy controls. A combination of these markers might provide useful means in the diagnosis of lung cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 1012-1016 |
| Number of pages | 5 |
| Journal | Japanese Journal of National Medical Services |
| Volume | 42 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1988 |
| Externally published | Yes |
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Clinical evaluation of tumor markers in serum and bronchoalveolar lavage fluid in patients with lung cancer. / Fujii, Masafumi; Kiura, Katsuyuki.
In: Japanese Journal of National Medical Services, Vol. 42, No. 11, 1988, p. 1012-1016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical evaluation of tumor markers in serum and bronchoalveolar lavage fluid in patients with lung cancer
AU - Fujii, Masafumi
AU - Kiura, Katsuyuki
PY - 1988
Y1 - 1988
N2 - Serum and bronchoalveolar lavage fluid levels of several tumor markers were measured in 71 patients with lung cancer, 36 patients with benign lung diseases and 100 healthy controls. The mean level and the positive rate of serum carcinoembryonic antigen (CEA) in patients with lung cancer (10.9 ng/ml, 43.7%) were statistically higher than those in patients with benign lung diseases (1.6 ng/ml, 8.3%). The mean level and the positive rate of serum neuron-specific-enolase (NSE) in patients with lung cancer (14.8 ng/ml, 45.1%) were statistically higher than those in patients with benign lung diseases (6.5 ng/ml, 11.1%), and patients with small cell carcinoma showed the higher mean level and higher positive rate of serum NSE compared to patients with other histologic types of lung cancer. Serum levels of ferritin, β2-microglobulin (β2MG), immunosuppressive acidic protein and tissue polypeptide antigen showed poor diagnostic values. The mean levels of bronchoalveolar lavage fluid CEA, ferritin and β2MG in patients with lung cancer were statistically higher than those in patients with benign lung disease and healthy controls. A combination of these markers might provide useful means in the diagnosis of lung cancer.
AB - Serum and bronchoalveolar lavage fluid levels of several tumor markers were measured in 71 patients with lung cancer, 36 patients with benign lung diseases and 100 healthy controls. The mean level and the positive rate of serum carcinoembryonic antigen (CEA) in patients with lung cancer (10.9 ng/ml, 43.7%) were statistically higher than those in patients with benign lung diseases (1.6 ng/ml, 8.3%). The mean level and the positive rate of serum neuron-specific-enolase (NSE) in patients with lung cancer (14.8 ng/ml, 45.1%) were statistically higher than those in patients with benign lung diseases (6.5 ng/ml, 11.1%), and patients with small cell carcinoma showed the higher mean level and higher positive rate of serum NSE compared to patients with other histologic types of lung cancer. Serum levels of ferritin, β2-microglobulin (β2MG), immunosuppressive acidic protein and tissue polypeptide antigen showed poor diagnostic values. The mean levels of bronchoalveolar lavage fluid CEA, ferritin and β2MG in patients with lung cancer were statistically higher than those in patients with benign lung disease and healthy controls. A combination of these markers might provide useful means in the diagnosis of lung cancer.
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U2 - 10.11261/iryo1946.42.1012
DO - 10.11261/iryo1946.42.1012
M3 - Article
VL - 42
SP - 1012
EP - 1016
JO - IRYO - Japanese Journal of National Medical Services
JF - IRYO - Japanese Journal of National Medical Services
SN - 0021-1699
IS - 11
ER -