Clinical evaluation of tumor markers in serum and bronchoalveolar lavage fluid in patients with lung cancer

Masafumi Fujii, Katsuyuki Kiura

Research output: Contribution to journalArticle

Abstract

Serum and bronchoalveolar lavage fluid levels of several tumor markers were measured in 71 patients with lung cancer, 36 patients with benign lung diseases and 100 healthy controls. The mean level and the positive rate of serum carcinoembryonic antigen (CEA) in patients with lung cancer (10.9 ng/ml, 43.7%) were statistically higher than those in patients with benign lung diseases (1.6 ng/ml, 8.3%). The mean level and the positive rate of serum neuron-specific-enolase (NSE) in patients with lung cancer (14.8 ng/ml, 45.1%) were statistically higher than those in patients with benign lung diseases (6.5 ng/ml, 11.1%), and patients with small cell carcinoma showed the higher mean level and higher positive rate of serum NSE compared to patients with other histologic types of lung cancer. Serum levels of ferritin, β2-microglobulin (β2MG), immunosuppressive acidic protein and tissue polypeptide antigen showed poor diagnostic values. The mean levels of bronchoalveolar lavage fluid CEA, ferritin and β2MG in patients with lung cancer were statistically higher than those in patients with benign lung disease and healthy controls. A combination of these markers might provide useful means in the diagnosis of lung cancer.

Original languageEnglish
Pages (from-to)1012-1016
Number of pages5
JournalJapanese Journal of National Medical Services
Volume42
Issue number11
DOIs
Publication statusPublished - 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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