Abstract
Purpose: The early diagnosis of bladder cancer allows for effective local treatment and optimizes the success of surgical therapy. Basic fetoprotein (BFP), measured using a rapid latex immuno-agglutination method, was introduced for the detection of transitional cell carcinoma. The objective of this study was to determine whether there was a correlation between urine BFP level and the grade or stage of bladder cancer, and whether the level could serve as a biochemical marker of bladder cancer. Materials and Methods: Single voided specimens were obtained from 66 patients with confirmed or suspicious bladder cancer on cystoscopy, urine cytology or BFP. Each sample was divided into 3 aliquots of which 1 was for urine analysis, 1 was tested for BFP according to latex immuno-agglutination method and 1 was sent for cytological examination. All patients subsequently under-went bladder biopsy. Results: There were 54 (82%)patients with biopsy confirmed bladder cancer and 12 (18%) with benign conditions of the bladder. Overall sensitivity with BFP and urine cytology was 38.9% and 48.1% respectively. Specificity was 58.3% and 75.0%, and positive predictive value was 80.8% and 89.7%, respectively. The positive rate of BFP and cytology was higher in invasive cancer (75% and 100%, respectively) than in superficial cancer (36% and 28%). There was no correlation between BFP level and tumor grade, while cytology had a strong association. Linear regression analysis showed the significant correlation between BFP level and tumor size (r = 0.695, p < 0.0001). The detection rate of bladder cancer was higher by the combination of BFP and cytology than by using alone. Conclusions: BFP in conjunction with urine cytology can increase the detection rate of bladder cancer. But BFP alone cannot be used as a screening test for bladder cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 579-583 |
| Number of pages | 5 |
| Journal | Japanese Journal of Urology |
| Volume | 91 |
| Issue number | 7-8 |
| Publication status | Published - 2000 |
| Externally published | Yes |
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Keywords
- BFP
- Bladder cancer
- Tumor marker
ASJC Scopus subject areas
- Urology
Cite this
Clinical evaluation of basic fetoprotein in bladder cancer. / Ichikawa, T.; Nakayama, Y.; Yamada, Daisuke; Saegusa, M.; Asano, S.; Aramaki, K.
In: Japanese Journal of Urology, Vol. 91, No. 7-8, 2000, p. 579-583.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical evaluation of basic fetoprotein in bladder cancer
AU - Ichikawa, T.
AU - Nakayama, Y.
AU - Yamada, Daisuke
AU - Saegusa, M.
AU - Asano, S.
AU - Aramaki, K.
PY - 2000
Y1 - 2000
N2 - Purpose: The early diagnosis of bladder cancer allows for effective local treatment and optimizes the success of surgical therapy. Basic fetoprotein (BFP), measured using a rapid latex immuno-agglutination method, was introduced for the detection of transitional cell carcinoma. The objective of this study was to determine whether there was a correlation between urine BFP level and the grade or stage of bladder cancer, and whether the level could serve as a biochemical marker of bladder cancer. Materials and Methods: Single voided specimens were obtained from 66 patients with confirmed or suspicious bladder cancer on cystoscopy, urine cytology or BFP. Each sample was divided into 3 aliquots of which 1 was for urine analysis, 1 was tested for BFP according to latex immuno-agglutination method and 1 was sent for cytological examination. All patients subsequently under-went bladder biopsy. Results: There were 54 (82%)patients with biopsy confirmed bladder cancer and 12 (18%) with benign conditions of the bladder. Overall sensitivity with BFP and urine cytology was 38.9% and 48.1% respectively. Specificity was 58.3% and 75.0%, and positive predictive value was 80.8% and 89.7%, respectively. The positive rate of BFP and cytology was higher in invasive cancer (75% and 100%, respectively) than in superficial cancer (36% and 28%). There was no correlation between BFP level and tumor grade, while cytology had a strong association. Linear regression analysis showed the significant correlation between BFP level and tumor size (r = 0.695, p < 0.0001). The detection rate of bladder cancer was higher by the combination of BFP and cytology than by using alone. Conclusions: BFP in conjunction with urine cytology can increase the detection rate of bladder cancer. But BFP alone cannot be used as a screening test for bladder cancer.
AB - Purpose: The early diagnosis of bladder cancer allows for effective local treatment and optimizes the success of surgical therapy. Basic fetoprotein (BFP), measured using a rapid latex immuno-agglutination method, was introduced for the detection of transitional cell carcinoma. The objective of this study was to determine whether there was a correlation between urine BFP level and the grade or stage of bladder cancer, and whether the level could serve as a biochemical marker of bladder cancer. Materials and Methods: Single voided specimens were obtained from 66 patients with confirmed or suspicious bladder cancer on cystoscopy, urine cytology or BFP. Each sample was divided into 3 aliquots of which 1 was for urine analysis, 1 was tested for BFP according to latex immuno-agglutination method and 1 was sent for cytological examination. All patients subsequently under-went bladder biopsy. Results: There were 54 (82%)patients with biopsy confirmed bladder cancer and 12 (18%) with benign conditions of the bladder. Overall sensitivity with BFP and urine cytology was 38.9% and 48.1% respectively. Specificity was 58.3% and 75.0%, and positive predictive value was 80.8% and 89.7%, respectively. The positive rate of BFP and cytology was higher in invasive cancer (75% and 100%, respectively) than in superficial cancer (36% and 28%). There was no correlation between BFP level and tumor grade, while cytology had a strong association. Linear regression analysis showed the significant correlation between BFP level and tumor size (r = 0.695, p < 0.0001). The detection rate of bladder cancer was higher by the combination of BFP and cytology than by using alone. Conclusions: BFP in conjunction with urine cytology can increase the detection rate of bladder cancer. But BFP alone cannot be used as a screening test for bladder cancer.
KW - BFP
KW - Bladder cancer
KW - Tumor marker
UR - http://www.scopus.com/inward/record.url?scp=0033850505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033850505&partnerID=8YFLogxK
M3 - Article
C2 - 10965742
AN - SCOPUS:0033850505
VL - 91
SP - 579
EP - 583
JO - Japanese Journal of Urology
JF - Japanese Journal of Urology
SN - 0021-5287
IS - 7-8
ER -