Clinical Effect of Low-Dose, Long-Term Roxithromycin Chemotherapy in Patients with Chronic Sinusitis

Nobuhiko Kimura, Keiko Nishioka, Kazunori Nishizaki, Teruhiro Ogawa, Yoshihiro Naitou, Yu Masuda

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We studied the clinical efficacy of roxithromycin (RXM) administered at the daily dosage of one tablet (150mg) for 3 months in 30 patients with chronic sinusitis. The effectiveness of this drug was evaluated on a four-point scale. Subjective and objective symptoms disappeared or decreased markedly, especially postnasal drip and nature of discharge in 80 percent or more of the patients. All symptoms significantly decreased (P <0.001; headache P <0.05), except for the sensation of foul odor. Symptoms improved even in those cases in which Haemophilus influenzae was detected. It is suggested that RXM produces some clinically beneficial effect through an immunological and or anti-inflammatory mechanisms in addition to its antibiotic effect.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalActa Medica Okayama
Issue number1
Publication statusPublished - Feb 1997



  • Chronic sinusitis
  • Clinical evaluation
  • Long-term
  • Low-dose administration
  • Roxithromycin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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