Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration

Mitsuko Yuzawa, Shin Yoneya, Masanobu Uyama, Kanji Takahashi, Muneyasu Takeda, Fumio Shiraga, Tokuhiko Miki, Kunihiko Shiraki, Kazuhiko Hayashi, Yuichiro Ogura, Sadao Komemushi, Mizuo Matsui

Research output: Contribution to journalArticle

Abstract

PURPOSE: To evaluate the proper clinical dosage of indocyanine green(ICG) in angiography for detecting choroidal neovascularization(CNV) of exudative age-related macular degeneration(AMD). SUBJECTS AND METHODS: Indocyanine green angiography (IA) was performed using a randomized crossover method with two different doses on two occasions. Ease of detection, side effects and clinical serum data were also evaluated. RESULTS: Among the 39 eyes, detection of CNV using 12.5 mg and 25 mg was most effective in 21 and 31 eyes respectively, showing a statistically significant difference. Slight vomiting was observed temporarily in one patient who had taken 25 mg. CONCLUSION: A dose of 25 mg is appropriate for detection of CNV of exudative AMD and this dosage raises no safety concerns.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalJournal of Japanese Ophthalmological Society
Volume106
Issue number2
Publication statusPublished - Feb 2002
Externally publishedYes

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Choroidal Neovascularization
Indocyanine Green
Macular Degeneration
Angiography
Vomiting
Safety
Serum

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration. / Yuzawa, Mitsuko; Yoneya, Shin; Uyama, Masanobu; Takahashi, Kanji; Takeda, Muneyasu; Shiraga, Fumio; Miki, Tokuhiko; Shiraki, Kunihiko; Hayashi, Kazuhiko; Ogura, Yuichiro; Komemushi, Sadao; Matsui, Mizuo.

In: Journal of Japanese Ophthalmological Society, Vol. 106, No. 2, 02.2002, p. 89-98.

Research output: Contribution to journalArticle

Yuzawa, M, Yoneya, S, Uyama, M, Takahashi, K, Takeda, M, Shiraga, F, Miki, T, Shiraki, K, Hayashi, K, Ogura, Y, Komemushi, S & Matsui, M 2002, 'Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration', Journal of Japanese Ophthalmological Society, vol. 106, no. 2, pp. 89-98.
Yuzawa, Mitsuko ; Yoneya, Shin ; Uyama, Masanobu ; Takahashi, Kanji ; Takeda, Muneyasu ; Shiraga, Fumio ; Miki, Tokuhiko ; Shiraki, Kunihiko ; Hayashi, Kazuhiko ; Ogura, Yuichiro ; Komemushi, Sadao ; Matsui, Mizuo. / Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration. In: Journal of Japanese Ophthalmological Society. 2002 ; Vol. 106, No. 2. pp. 89-98.
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AU - Yuzawa, Mitsuko

AU - Yoneya, Shin

AU - Uyama, Masanobu

AU - Takahashi, Kanji

AU - Takeda, Muneyasu

AU - Shiraga, Fumio

AU - Miki, Tokuhiko

AU - Shiraki, Kunihiko

AU - Hayashi, Kazuhiko

AU - Ogura, Yuichiro

AU - Komemushi, Sadao

AU - Matsui, Mizuo

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AB - PURPOSE: To evaluate the proper clinical dosage of indocyanine green(ICG) in angiography for detecting choroidal neovascularization(CNV) of exudative age-related macular degeneration(AMD). SUBJECTS AND METHODS: Indocyanine green angiography (IA) was performed using a randomized crossover method with two different doses on two occasions. Ease of detection, side effects and clinical serum data were also evaluated. RESULTS: Among the 39 eyes, detection of CNV using 12.5 mg and 25 mg was most effective in 21 and 31 eyes respectively, showing a statistically significant difference. Slight vomiting was observed temporarily in one patient who had taken 25 mg. CONCLUSION: A dose of 25 mg is appropriate for detection of CNV of exudative AMD and this dosage raises no safety concerns.

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