Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration

Mitsuko Yuzawa, Shin Yoneya, Masanobu Uyama, Kanji Takahashi, Muneyasu Takeda, Fumio Shiraga, Tokuhiko Miki, Kunihiko Shiraki, Kazuhiko Hayashi, Yuichiro Ogura, Sadao Komemushi, Mizuo Matsui

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Abstract

PURPOSE: To evaluate the proper clinical dosage of indocyanine green(ICG) in angiography for detecting choroidal neovascularization(CNV) of exudative age-related macular degeneration(AMD). SUBJECTS AND METHODS: Indocyanine green angiography (IA) was performed using a randomized crossover method with two different doses on two occasions. Ease of detection, side effects and clinical serum data were also evaluated. RESULTS: Among the 39 eyes, detection of CNV using 12.5 mg and 25 mg was most effective in 21 and 31 eyes respectively, showing a statistically significant difference. Slight vomiting was observed temporarily in one patient who had taken 25 mg. CONCLUSION: A dose of 25 mg is appropriate for detection of CNV of exudative AMD and this dosage raises no safety concerns.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalJournal of Japanese Ophthalmological Society
Volume106
Issue number2
Publication statusPublished - Feb 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

Yuzawa, M., Yoneya, S., Uyama, M., Takahashi, K., Takeda, M., Shiraga, F., Miki, T., Shiraki, K., Hayashi, K., Ogura, Y., Komemushi, S., & Matsui, M. (2002). Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration. Journal of Japanese Ophthalmological Society, 106(2), 89-98.