Clinical Correlations of Aggrecan in the Resected Medial Rectus Muscle of Patients with Intermittent Exotropia

Takashi Yamane, Toshihiko Matsuo, Satoshi Hasebe, Hiroshi Ohtsuki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The purpose of this study was to elucidate the role of extracellular matrix components such as aggrecan, fibronectin, and laminin in the extraocular muscle of patients with strabismus. Resected tissues of the medial rectus muscle of 47 patients with intermittent exotropia obtained during recession-resection surgery were frozen under liquid nitrogen and pulverized by a Freezer/Mill to solubilize the tissue for enzyme immunoassay. The total amounts of aggrecan, fibronectin, and laminin in the resected tissue were correlated with clinical data of patients such as age, exodeviation, and refractive error. The amount of aggrecan decreased significantly with the advance of age (P < 0.0001, Spearman rank correlation test), while the amount of laminin or fibronectin had no correlation with age. Patients with basic type intermittent exotropia showed larger, although not significantly, amounts of aggrecan than those with convergence insufficiency type (P = 0.0538, Mann-Whitney U-test). The amount of aggrecan may be related to motor aspects of intermittent exotropia.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalActa medica Okayama
Volume57
Issue number4
Publication statusPublished - Aug 2003

Keywords

  • Aggrecan
  • Extraocular muscle
  • Fibronectin
  • Intermittent exotropia
  • Laminin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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