Abstract
Background Lung transplants have produced very favorable outcomes for patients with interstitial lung disease (ILD) in Japan. However, because of the severe donor lung shortage, patients must wait approximately 2.5 years before they can undergo transplantation and many candidates die before allocation. We reveal the clinical characteristics of Japanese patients with ILD who are candidates for lung transplants and the risk factors for early death while on the waiting list. Methods We retrospectively reviewed the clinical data of patients registered in the Japan Organ Transplant Network from Okayama University Hospital who are candidates for cadaveric lung transplants for ILD between 1999 and 2015. Results Fifty-three patients with ILD were included (24 patients with idiopathic pulmonary fibrosis and 29 others). They had severe pulmonary dysfunction and low exercise tolerability. The median waiting time for transplantation was 462 days, and 22 patients died before allocation. Patients who died before 462 days without undergoing transplantation had more severe dyspnea, shorter 6-minute walk distance (6MWD), and lower performance status than those who waited ≥462 days. Conclusions Japanese candidates for cadaveric lung transplants for ILD have severe pulmonary dysfunction. Severe dyspnea, short 6MWD, and low performance status are risk factors for early death while on the waiting list.
| Original language | English |
|---|---|
| Pages (from-to) | 264-269 |
| Number of pages | 6 |
| Journal | Respiratory Investigation |
| Volume | 55 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 1 2017 |
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Keywords
- Interstitial lung disease
- Lung allocation system
- Lung transplant
- Performance status
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Clinical characteristics of Japanese candidates for lung transplant for interstitial lung disease and risk factors for early death while on the waiting list. / Higo, Hisao; Kurosaki, Takeshi; Ichihara, Eiki; Kubo, Toshio; Miyoshi, Kentaroh; Otani, Shinji; Sugimoto, Seiichiro; Yamane, Masaomi; Miyahara, Nobuaki; Kiura, Katsuyuki; Miyoshi, Shinichiro; Oto, Takahiro.
In: Respiratory Investigation, Vol. 55, No. 4, 01.07.2017, p. 264-269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical characteristics of Japanese candidates for lung transplant for interstitial lung disease and risk factors for early death while on the waiting list
AU - Higo, Hisao
AU - Kurosaki, Takeshi
AU - Ichihara, Eiki
AU - Kubo, Toshio
AU - Miyoshi, Kentaroh
AU - Otani, Shinji
AU - Sugimoto, Seiichiro
AU - Yamane, Masaomi
AU - Miyahara, Nobuaki
AU - Kiura, Katsuyuki
AU - Miyoshi, Shinichiro
AU - Oto, Takahiro
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background Lung transplants have produced very favorable outcomes for patients with interstitial lung disease (ILD) in Japan. However, because of the severe donor lung shortage, patients must wait approximately 2.5 years before they can undergo transplantation and many candidates die before allocation. We reveal the clinical characteristics of Japanese patients with ILD who are candidates for lung transplants and the risk factors for early death while on the waiting list. Methods We retrospectively reviewed the clinical data of patients registered in the Japan Organ Transplant Network from Okayama University Hospital who are candidates for cadaveric lung transplants for ILD between 1999 and 2015. Results Fifty-three patients with ILD were included (24 patients with idiopathic pulmonary fibrosis and 29 others). They had severe pulmonary dysfunction and low exercise tolerability. The median waiting time for transplantation was 462 days, and 22 patients died before allocation. Patients who died before 462 days without undergoing transplantation had more severe dyspnea, shorter 6-minute walk distance (6MWD), and lower performance status than those who waited ≥462 days. Conclusions Japanese candidates for cadaveric lung transplants for ILD have severe pulmonary dysfunction. Severe dyspnea, short 6MWD, and low performance status are risk factors for early death while on the waiting list.
AB - Background Lung transplants have produced very favorable outcomes for patients with interstitial lung disease (ILD) in Japan. However, because of the severe donor lung shortage, patients must wait approximately 2.5 years before they can undergo transplantation and many candidates die before allocation. We reveal the clinical characteristics of Japanese patients with ILD who are candidates for lung transplants and the risk factors for early death while on the waiting list. Methods We retrospectively reviewed the clinical data of patients registered in the Japan Organ Transplant Network from Okayama University Hospital who are candidates for cadaveric lung transplants for ILD between 1999 and 2015. Results Fifty-three patients with ILD were included (24 patients with idiopathic pulmonary fibrosis and 29 others). They had severe pulmonary dysfunction and low exercise tolerability. The median waiting time for transplantation was 462 days, and 22 patients died before allocation. Patients who died before 462 days without undergoing transplantation had more severe dyspnea, shorter 6-minute walk distance (6MWD), and lower performance status than those who waited ≥462 days. Conclusions Japanese candidates for cadaveric lung transplants for ILD have severe pulmonary dysfunction. Severe dyspnea, short 6MWD, and low performance status are risk factors for early death while on the waiting list.
KW - Interstitial lung disease
KW - Lung allocation system
KW - Lung transplant
KW - Performance status
UR - http://www.scopus.com/inward/record.url?scp=85021050500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021050500&partnerID=8YFLogxK
U2 - 10.1016/j.resinv.2017.03.002
DO - 10.1016/j.resinv.2017.03.002
M3 - Article
C2 - 28705305
AN - SCOPUS:85021050500
VL - 55
SP - 264
EP - 269
JO - Respiratory Investigation
JF - Respiratory Investigation
SN - 2212-5345
IS - 4
ER -