Clinical characteristics of fulminant-type autoimmune hepatitis: An analysis of eleven cases

Y. Miyake, Y. Iwasaki, R. Terada, T. Onishi, R. Okamoto, N. Sakai, K. Sakaguchi, Y. Shiratori

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54 Citations (Scopus)

Abstract

Background: Although a few adult cases of fulminant-type autoimmune hepatitis have been reported, their clinical features and prognosis have remained uncertain. Aim: To assess the clinical features and prognosis of patients with fulminant-type autoimmune hepatitis. Methods: Eleven patients (10%) diagnosed with fulminant-type autoimmune hepatitis in accordance with the 1999 criteria of the International Autoimmune Hepatitis Group were analysed. Results: All 11 patients were female, with a median age of 53 years. Five patients survived without liver transplantation, one received a liver transplantation, and five died without liver transplantation. Nine patients (82%) survived for 2 weeks or more following diagnosis, without liver transplantation. Except for the patient receiving a liver transplantation, serum total bilirubin levels measured during the clinical course were significantly higher in non-survivors than in survivors, although the accompanying serum alanine aminotransferase levels measured for the two groups were similar. Most significantly, serum total bilirubin levels in non-survivors worsened during days 8-15, while levels in survivors improved during the same period. Conclusions: The short-term prognosis for patients with fulminant-type autoimmune hepatitis may be good. However, patients whose serum total bilirubin levels worsen during days 8-15 should be considered forq2 liver transplantation.

Original languageEnglish
Pages (from-to)1347-1353
Number of pages7
JournalAlimentary Pharmacology and Therapeutics
Volume23
Issue number9
DOIs
Publication statusPublished - May 2006

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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