Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study

Koh Tadokoro, Ryuta Morihara, Yasuyuki Ohta, Nozomi Hishikawa, Satoko Kawano, Ryo Sasaki, Namiko Matsumoto, Emi Nomura, Yumiko Nakano, Yoshiaki Takahashi, Mami Takemoto, Toru Yamashita, Setsuko Ueno, Yosuke Wakutani, Yoshiki Takao, Nobutoshi Morimoto, Yumiko Kutoku, Yoshihide Sunada, Katsushi Taomoto, Yasuhiro ManabeKentaro Deguchi, Yasuto Higashi, Haruhiko Inufusa, Fukka You, Toshikazu Yoshikawa, Markus Matuschka Von Greiffenclau, Koji Abe

Research output: Contribution to journalArticle

Abstract

Oxidative stress is part of the entire pathological process that underlies the development of Alzheimer's disease (AD), including the mild cognitive impairment (MCI) stage. Twendee X (TwX) is a supplement containing a strong antioxidative mix of eight antioxidants, which has been shown to have a clinical and therapeutic benefit in AD model mice. Here, we conducted a multicenter, randomized, double-blind, and placebo-controlled prospective interventional study to evaluate the efficacy of TwX in mitigating MCI. The primary outcomes were differences in Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-revised (HDS-R) scores between baseline and six months for placebo and TwX groups. Seventy-eight subjects with MCI were randomized into placebo (n = 37) and TwX (n = 41) groups. MMSE scores at six months differed significantly between the TwX and placebo groups (p = 0.018), and HDS-R scores for the TwX group exhibited a significant improvement at six months relative to baseline (p = 0.025). The TwX group did not show any change in affective or activities of daily living scores at six months. The present study indicates that strong antioxidative supplement TwX is clinical beneficial for cognitive function in subjects with MCI.

Original languageEnglish
Pages (from-to)1063-1069
Number of pages7
JournalJournal of Alzheimer's Disease
Volume71
Issue number3
DOIs
Publication statusPublished - Jan 1 2019

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Placebos
Prospective Studies
Dementia
Alzheimer Disease
Pathologic Processes
Activities of Daily Living
Cognition
Oxidative Stress
Antioxidants
Cognitive Dysfunction
Therapeutics

Keywords

  • Dementia
  • dietary supplement
  • mild cognitive impairment
  • oxidative stress
  • randomized controlled trial

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment : A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study. / Tadokoro, Koh; Morihara, Ryuta; Ohta, Yasuyuki; Hishikawa, Nozomi; Kawano, Satoko; Sasaki, Ryo; Matsumoto, Namiko; Nomura, Emi; Nakano, Yumiko; Takahashi, Yoshiaki; Takemoto, Mami; Yamashita, Toru; Ueno, Setsuko; Wakutani, Yosuke; Takao, Yoshiki; Morimoto, Nobutoshi; Kutoku, Yumiko; Sunada, Yoshihide; Taomoto, Katsushi; Manabe, Yasuhiro; Deguchi, Kentaro; Higashi, Yasuto; Inufusa, Haruhiko; You, Fukka; Yoshikawa, Toshikazu; Von Greiffenclau, Markus Matuschka; Abe, Koji.

In: Journal of Alzheimer's Disease, Vol. 71, No. 3, 01.01.2019, p. 1063-1069.

Research output: Contribution to journalArticle

Tadokoro, K, Morihara, R, Ohta, Y, Hishikawa, N, Kawano, S, Sasaki, R, Matsumoto, N, Nomura, E, Nakano, Y, Takahashi, Y, Takemoto, M, Yamashita, T, Ueno, S, Wakutani, Y, Takao, Y, Morimoto, N, Kutoku, Y, Sunada, Y, Taomoto, K, Manabe, Y, Deguchi, K, Higashi, Y, Inufusa, H, You, F, Yoshikawa, T, Von Greiffenclau, MM & Abe, K 2019, 'Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study', Journal of Alzheimer's Disease, vol. 71, no. 3, pp. 1063-1069. https://doi.org/10.3233/JAD-190644
Tadokoro, Koh ; Morihara, Ryuta ; Ohta, Yasuyuki ; Hishikawa, Nozomi ; Kawano, Satoko ; Sasaki, Ryo ; Matsumoto, Namiko ; Nomura, Emi ; Nakano, Yumiko ; Takahashi, Yoshiaki ; Takemoto, Mami ; Yamashita, Toru ; Ueno, Setsuko ; Wakutani, Yosuke ; Takao, Yoshiki ; Morimoto, Nobutoshi ; Kutoku, Yumiko ; Sunada, Yoshihide ; Taomoto, Katsushi ; Manabe, Yasuhiro ; Deguchi, Kentaro ; Higashi, Yasuto ; Inufusa, Haruhiko ; You, Fukka ; Yoshikawa, Toshikazu ; Von Greiffenclau, Markus Matuschka ; Abe, Koji. / Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment : A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study. In: Journal of Alzheimer's Disease. 2019 ; Vol. 71, No. 3. pp. 1063-1069.
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AU - Morihara, Ryuta

AU - Ohta, Yasuyuki

AU - Hishikawa, Nozomi

AU - Kawano, Satoko

AU - Sasaki, Ryo

AU - Matsumoto, Namiko

AU - Nomura, Emi

AU - Nakano, Yumiko

AU - Takahashi, Yoshiaki

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AU - Takao, Yoshiki

AU - Morimoto, Nobutoshi

AU - Kutoku, Yumiko

AU - Sunada, Yoshihide

AU - Taomoto, Katsushi

AU - Manabe, Yasuhiro

AU - Deguchi, Kentaro

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