Abstract
Background:The aim of this study was to compare clinical and pathological outcomes after neoadjuvant chemotherapy between oestrogen receptor (ER)-positive invasive pure lobular carcinoma (ILC) and invasive ductal carcinoma (IDC).Methods:This analysis included 1895 patients (n=177 ILC; n=1718 IDC), with stage I-III breast cancer, who received neoadjuvant chemotherapy. Clinical and pathological response rates, the frequency of positive surgical margins and rate of breast-conserving surgery were compared.Results:There was a trend for fewer good clinical responses in ILC compared with IDC. Tumour downstaging was significantly less frequent in ILC. Positive or close surgical resection margins were more frequent in ILC, and breast-conserving surgery was less common (P
| Original language | English |
|---|---|
| Pages (from-to) | 285-291 |
| Number of pages | 7 |
| Journal | British Journal of Cancer |
| Volume | 108 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2013 |
| Externally published | Yes |
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Keywords
- Breast cancer
- Clinical response
- Lobular carcinoma
- Margins
- Neoadjuvant chemotherapy
- Pathological complete response
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Clinical benefit from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal and lobular carcinomas. / Delpech, Y.; Coutant, C.; Hsu, L.; Barranger, E.; Iwamoto, Takayuki; Barcenas, C. H.; Hortobagyi, G. N.; Rouzier, R.; Esteva, F. J.; Pusztai, L.
In: British Journal of Cancer, Vol. 108, No. 2, 02.2013, p. 285-291.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical benefit from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal and lobular carcinomas
AU - Delpech, Y.
AU - Coutant, C.
AU - Hsu, L.
AU - Barranger, E.
AU - Iwamoto, Takayuki
AU - Barcenas, C. H.
AU - Hortobagyi, G. N.
AU - Rouzier, R.
AU - Esteva, F. J.
AU - Pusztai, L.
PY - 2013/2
Y1 - 2013/2
N2 - Background:The aim of this study was to compare clinical and pathological outcomes after neoadjuvant chemotherapy between oestrogen receptor (ER)-positive invasive pure lobular carcinoma (ILC) and invasive ductal carcinoma (IDC).Methods:This analysis included 1895 patients (n=177 ILC; n=1718 IDC), with stage I-III breast cancer, who received neoadjuvant chemotherapy. Clinical and pathological response rates, the frequency of positive surgical margins and rate of breast-conserving surgery were compared.Results:There was a trend for fewer good clinical responses in ILC compared with IDC. Tumour downstaging was significantly less frequent in ILC. Positive or close surgical resection margins were more frequent in ILC, and breast-conserving surgery was less common (P
AB - Background:The aim of this study was to compare clinical and pathological outcomes after neoadjuvant chemotherapy between oestrogen receptor (ER)-positive invasive pure lobular carcinoma (ILC) and invasive ductal carcinoma (IDC).Methods:This analysis included 1895 patients (n=177 ILC; n=1718 IDC), with stage I-III breast cancer, who received neoadjuvant chemotherapy. Clinical and pathological response rates, the frequency of positive surgical margins and rate of breast-conserving surgery were compared.Results:There was a trend for fewer good clinical responses in ILC compared with IDC. Tumour downstaging was significantly less frequent in ILC. Positive or close surgical resection margins were more frequent in ILC, and breast-conserving surgery was less common (P
KW - Breast cancer
KW - Clinical response
KW - Lobular carcinoma
KW - Margins
KW - Neoadjuvant chemotherapy
KW - Pathological complete response
UR - http://www.scopus.com/inward/record.url?scp=84873567924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873567924&partnerID=8YFLogxK
U2 - 10.1038/bjc.2012.557
DO - 10.1038/bjc.2012.557
M3 - Article
C2 - 23299541
AN - SCOPUS:84873567924
VL - 108
SP - 285
EP - 291
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 2
ER -