[Clinical assessment of granulocyte colony-stimulating factor producing lung cancer].

Eisuke Matsuda, Kazunori Okabe, Hiroyuki Tao, Hiromasa Yamamoto, Katsutoshi Hirazawa, Seiki Kobayashi, Tomoyuki Murakami, Kazuro Sugi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this study was to reveal the clinicopathological feature of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. Nine cases of G-CSF producing lung cancer from July 2003 to July 2008 were retrospectively evaluated. All cases were male, 8 cases were poorly differentiated carcinoma. Average of leucocyte and serum G-CSF were 23,378/microl and 128.6 pg/ml respectively. Five cases had febrile symptom, average of serum C-reactive protein (CRP) was 13.37 mg/dl. Immunohistological examination showed positive staining for G-CSF in 6 cases. Serum interleukin-6 (IL-6) level was elevated in 3 cases. Clinical stages were IB in 2, IIB in 2, IIIA in 3 and IIIB in 2 patients. Chemotherapy was performed for patients with stage IIIB. Operation was performed for the other cases. Five cases were died within 12 months, whereas 4 cases are surviving for 6 to 16 months. Generally, the prognosis of G-CSF producing lung cancer seems to be poor, but in our institute there were 2 cases who lived over 1 year without disease. It is important to establish more effective adjuvant therapy for G-CSF producing tumor.

Original languageEnglish
Pages (from-to)445-449
Number of pages5
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume64
Issue number6
Publication statusPublished - Jun 2011
Externally publishedYes

Fingerprint

Granulocyte Colony-Stimulating Factor
Lung Neoplasms
Serum
C-Reactive Protein
Blood Proteins
Interleukin-6
Leukocytes
Fever
Staining and Labeling
Carcinoma
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Matsuda, E., Okabe, K., Tao, H., Yamamoto, H., Hirazawa, K., Kobayashi, S., ... Sugi, K. (2011). [Clinical assessment of granulocyte colony-stimulating factor producing lung cancer]. Kyobu geka. The Japanese journal of thoracic surgery, 64(6), 445-449.

[Clinical assessment of granulocyte colony-stimulating factor producing lung cancer]. / Matsuda, Eisuke; Okabe, Kazunori; Tao, Hiroyuki; Yamamoto, Hiromasa; Hirazawa, Katsutoshi; Kobayashi, Seiki; Murakami, Tomoyuki; Sugi, Kazuro.

In: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 64, No. 6, 06.2011, p. 445-449.

Research output: Contribution to journalArticle

Matsuda, E, Okabe, K, Tao, H, Yamamoto, H, Hirazawa, K, Kobayashi, S, Murakami, T & Sugi, K 2011, '[Clinical assessment of granulocyte colony-stimulating factor producing lung cancer].', Kyobu geka. The Japanese journal of thoracic surgery, vol. 64, no. 6, pp. 445-449.
Matsuda, Eisuke ; Okabe, Kazunori ; Tao, Hiroyuki ; Yamamoto, Hiromasa ; Hirazawa, Katsutoshi ; Kobayashi, Seiki ; Murakami, Tomoyuki ; Sugi, Kazuro. / [Clinical assessment of granulocyte colony-stimulating factor producing lung cancer]. In: Kyobu geka. The Japanese journal of thoracic surgery. 2011 ; Vol. 64, No. 6. pp. 445-449.
@article{329c11c7d8fe42aa811e5d2bd695a1e1,
title = "[Clinical assessment of granulocyte colony-stimulating factor producing lung cancer].",
abstract = "The aim of this study was to reveal the clinicopathological feature of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. Nine cases of G-CSF producing lung cancer from July 2003 to July 2008 were retrospectively evaluated. All cases were male, 8 cases were poorly differentiated carcinoma. Average of leucocyte and serum G-CSF were 23,378/microl and 128.6 pg/ml respectively. Five cases had febrile symptom, average of serum C-reactive protein (CRP) was 13.37 mg/dl. Immunohistological examination showed positive staining for G-CSF in 6 cases. Serum interleukin-6 (IL-6) level was elevated in 3 cases. Clinical stages were IB in 2, IIB in 2, IIIA in 3 and IIIB in 2 patients. Chemotherapy was performed for patients with stage IIIB. Operation was performed for the other cases. Five cases were died within 12 months, whereas 4 cases are surviving for 6 to 16 months. Generally, the prognosis of G-CSF producing lung cancer seems to be poor, but in our institute there were 2 cases who lived over 1 year without disease. It is important to establish more effective adjuvant therapy for G-CSF producing tumor.",
author = "Eisuke Matsuda and Kazunori Okabe and Hiroyuki Tao and Hiromasa Yamamoto and Katsutoshi Hirazawa and Seiki Kobayashi and Tomoyuki Murakami and Kazuro Sugi",
year = "2011",
month = "6",
language = "English",
volume = "64",
pages = "445--449",
journal = "Japanese Journal of Thoracic Surgery",
issn = "0021-5252",
publisher = "Nankodo Co., Ltd.",
number = "6",

}

TY - JOUR

T1 - [Clinical assessment of granulocyte colony-stimulating factor producing lung cancer].

AU - Matsuda, Eisuke

AU - Okabe, Kazunori

AU - Tao, Hiroyuki

AU - Yamamoto, Hiromasa

AU - Hirazawa, Katsutoshi

AU - Kobayashi, Seiki

AU - Murakami, Tomoyuki

AU - Sugi, Kazuro

PY - 2011/6

Y1 - 2011/6

N2 - The aim of this study was to reveal the clinicopathological feature of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. Nine cases of G-CSF producing lung cancer from July 2003 to July 2008 were retrospectively evaluated. All cases were male, 8 cases were poorly differentiated carcinoma. Average of leucocyte and serum G-CSF were 23,378/microl and 128.6 pg/ml respectively. Five cases had febrile symptom, average of serum C-reactive protein (CRP) was 13.37 mg/dl. Immunohistological examination showed positive staining for G-CSF in 6 cases. Serum interleukin-6 (IL-6) level was elevated in 3 cases. Clinical stages were IB in 2, IIB in 2, IIIA in 3 and IIIB in 2 patients. Chemotherapy was performed for patients with stage IIIB. Operation was performed for the other cases. Five cases were died within 12 months, whereas 4 cases are surviving for 6 to 16 months. Generally, the prognosis of G-CSF producing lung cancer seems to be poor, but in our institute there were 2 cases who lived over 1 year without disease. It is important to establish more effective adjuvant therapy for G-CSF producing tumor.

AB - The aim of this study was to reveal the clinicopathological feature of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. Nine cases of G-CSF producing lung cancer from July 2003 to July 2008 were retrospectively evaluated. All cases were male, 8 cases were poorly differentiated carcinoma. Average of leucocyte and serum G-CSF were 23,378/microl and 128.6 pg/ml respectively. Five cases had febrile symptom, average of serum C-reactive protein (CRP) was 13.37 mg/dl. Immunohistological examination showed positive staining for G-CSF in 6 cases. Serum interleukin-6 (IL-6) level was elevated in 3 cases. Clinical stages were IB in 2, IIB in 2, IIIA in 3 and IIIB in 2 patients. Chemotherapy was performed for patients with stage IIIB. Operation was performed for the other cases. Five cases were died within 12 months, whereas 4 cases are surviving for 6 to 16 months. Generally, the prognosis of G-CSF producing lung cancer seems to be poor, but in our institute there were 2 cases who lived over 1 year without disease. It is important to establish more effective adjuvant therapy for G-CSF producing tumor.

UR - http://www.scopus.com/inward/record.url?scp=79960591237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960591237&partnerID=8YFLogxK

M3 - Article

VL - 64

SP - 445

EP - 449

JO - Japanese Journal of Thoracic Surgery

JF - Japanese Journal of Thoracic Surgery

SN - 0021-5252

IS - 6

ER -