Clinical application of cascade filtration combined with glassbead adsorbents in cancer patients

S. Shiozaki, K. Sakagami, M. Miyazaki, J. Matsuoka, S. Uchida, S. Saito, T. Fujiwara, K. Orita

Research output: Contribution to journalArticle

Abstract

Cascade filtration (CF) was applied to patients with advanced cancers. To selectively remove immunosuppressive factors with molecular weight lower than albumin, adsorbents combined with CF were examined. Among 11 kinds of adsorbents, glassbead adsorbents with pore size of 100Å were the most effective in adsorbing such substances. Clinically, a column packed with glassbead adsorbents was concomitantly used with CF. The second filtrate was passed through the column and returned to the patient. The removal rate of immunosuppressive substances with molecular weight lower than albumin was only 20% by CF alone, but more than 50% by CF combined with glassbead adsorbents. Clinical symptoms such as severe back pain and general malaise were drastically improved during and after therapy. These results suggest that CF combined with glassbead adsorbents is an effective adjunctive modality to cancer therapy.

Original languageEnglish
Pages (from-to)400-404
Number of pages5
JournalInternational Journal of Artificial Organs
Volume12
Issue number6
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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