Clinical and laboratory studies on a patient with early onset periodontitis and her family members. A case report.

K. Takahashi, M. Takigawa, H. Hara, A. Nagai, Shogo Takashiba, F. Nishimura, T. Chihara, H. Ohyama, N. Satoh, H. Kurihara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Extensive clinical, microbiological, hematological, and immunological studies were performed on a patient with early onset periodontitis (EOP) and two other members of the family. The proband, a 27-year-old female, had early onset periodontitis and a high level of serum rheumatoid factors (RF) with no diagnosable medical disease. Her mother had lost all her teeth at the age of 50 because of advanced periodontitis, while her elder sister was unaffected by periodontitis. Neither the proband's periodontally-affected mother nor her unaffected sister exhibited a detectable level of RF. In this study, we examined: 1) serum immunoglobulin G (IgG) antibody titers against putative periodontal pathogenic bacteria; 2) peripheral neutrophil functions; 3) phenotypic analyses of peripheral lymphocyte subpopulations; and 4) peripheral lymphocyte functions (T cell proliferative activity, ability of cytokine [interleukin (IL)-2, tumor necrosis factor-alpha, interferon-gamma, IL-6 and IL-8] and IgG and IgM productivity). High antibody titers to Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Campylobacter rectus were detected in the sera of the proband, as were high serum antibody titers to P. gingivalis in the mother and to C. rectus in the unaffected sister compared to the non-periodontitis affected subjects. The proband also showed enhanced neutrophil chemotaxis; a high percentage of pan-B cells; and high productivity of IL-6, IgG, and IgM compared to individuals who were not periodontally affected. The mother showed slightly low helper/induced T cells (Th/i) suppressor/cytotoxic T cells (Ts/c) ratios due to the elevated count of Ts/c, and high IFN-gamma productivity compared to control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
Pages (from-to)403-412
Number of pages10
JournalJournal of Periodontology
Volume66
Issue number5
Publication statusPublished - May 1995

Fingerprint

Aggressive Periodontitis
Campylobacter rectus
Mothers
Siblings
Porphyromonas gingivalis
Immunoglobulin G
Rheumatoid Factor
Periodontitis
Serum
Efficiency
Immunoglobulin M
Antibodies
Interleukin-6
Neutrophils
T-Lymphocytes
Aggregatibacter actinomycetemcomitans
Aptitude
Lymphocyte Subsets
Chemotaxis
Helper-Inducer T-Lymphocytes

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Takahashi, K., Takigawa, M., Hara, H., Nagai, A., Takashiba, S., Nishimura, F., ... Kurihara, H. (1995). Clinical and laboratory studies on a patient with early onset periodontitis and her family members. A case report. Journal of Periodontology, 66(5), 403-412.

Clinical and laboratory studies on a patient with early onset periodontitis and her family members. A case report. / Takahashi, K.; Takigawa, M.; Hara, H.; Nagai, A.; Takashiba, Shogo; Nishimura, F.; Chihara, T.; Ohyama, H.; Satoh, N.; Kurihara, H.

In: Journal of Periodontology, Vol. 66, No. 5, 05.1995, p. 403-412.

Research output: Contribution to journalArticle

Takahashi, K, Takigawa, M, Hara, H, Nagai, A, Takashiba, S, Nishimura, F, Chihara, T, Ohyama, H, Satoh, N & Kurihara, H 1995, 'Clinical and laboratory studies on a patient with early onset periodontitis and her family members. A case report.', Journal of Periodontology, vol. 66, no. 5, pp. 403-412.
Takahashi, K. ; Takigawa, M. ; Hara, H. ; Nagai, A. ; Takashiba, Shogo ; Nishimura, F. ; Chihara, T. ; Ohyama, H. ; Satoh, N. ; Kurihara, H. / Clinical and laboratory studies on a patient with early onset periodontitis and her family members. A case report. In: Journal of Periodontology. 1995 ; Vol. 66, No. 5. pp. 403-412.
@article{614a98a73d4c4a9e88816c2929e66787,
title = "Clinical and laboratory studies on a patient with early onset periodontitis and her family members. A case report.",
abstract = "Extensive clinical, microbiological, hematological, and immunological studies were performed on a patient with early onset periodontitis (EOP) and two other members of the family. The proband, a 27-year-old female, had early onset periodontitis and a high level of serum rheumatoid factors (RF) with no diagnosable medical disease. Her mother had lost all her teeth at the age of 50 because of advanced periodontitis, while her elder sister was unaffected by periodontitis. Neither the proband's periodontally-affected mother nor her unaffected sister exhibited a detectable level of RF. In this study, we examined: 1) serum immunoglobulin G (IgG) antibody titers against putative periodontal pathogenic bacteria; 2) peripheral neutrophil functions; 3) phenotypic analyses of peripheral lymphocyte subpopulations; and 4) peripheral lymphocyte functions (T cell proliferative activity, ability of cytokine [interleukin (IL)-2, tumor necrosis factor-alpha, interferon-gamma, IL-6 and IL-8] and IgG and IgM productivity). High antibody titers to Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Campylobacter rectus were detected in the sera of the proband, as were high serum antibody titers to P. gingivalis in the mother and to C. rectus in the unaffected sister compared to the non-periodontitis affected subjects. The proband also showed enhanced neutrophil chemotaxis; a high percentage of pan-B cells; and high productivity of IL-6, IgG, and IgM compared to individuals who were not periodontally affected. The mother showed slightly low helper/induced T cells (Th/i) suppressor/cytotoxic T cells (Ts/c) ratios due to the elevated count of Ts/c, and high IFN-gamma productivity compared to control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "K. Takahashi and M. Takigawa and H. Hara and A. Nagai and Shogo Takashiba and F. Nishimura and T. Chihara and H. Ohyama and N. Satoh and H. Kurihara",
year = "1995",
month = "5",
language = "English",
volume = "66",
pages = "403--412",
journal = "Journal of Periodontology",
issn = "0022-3492",
publisher = "American Academy of Periodontology",
number = "5",

}

TY - JOUR

T1 - Clinical and laboratory studies on a patient with early onset periodontitis and her family members. A case report.

AU - Takahashi, K.

AU - Takigawa, M.

AU - Hara, H.

AU - Nagai, A.

AU - Takashiba, Shogo

AU - Nishimura, F.

AU - Chihara, T.

AU - Ohyama, H.

AU - Satoh, N.

AU - Kurihara, H.

PY - 1995/5

Y1 - 1995/5

N2 - Extensive clinical, microbiological, hematological, and immunological studies were performed on a patient with early onset periodontitis (EOP) and two other members of the family. The proband, a 27-year-old female, had early onset periodontitis and a high level of serum rheumatoid factors (RF) with no diagnosable medical disease. Her mother had lost all her teeth at the age of 50 because of advanced periodontitis, while her elder sister was unaffected by periodontitis. Neither the proband's periodontally-affected mother nor her unaffected sister exhibited a detectable level of RF. In this study, we examined: 1) serum immunoglobulin G (IgG) antibody titers against putative periodontal pathogenic bacteria; 2) peripheral neutrophil functions; 3) phenotypic analyses of peripheral lymphocyte subpopulations; and 4) peripheral lymphocyte functions (T cell proliferative activity, ability of cytokine [interleukin (IL)-2, tumor necrosis factor-alpha, interferon-gamma, IL-6 and IL-8] and IgG and IgM productivity). High antibody titers to Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Campylobacter rectus were detected in the sera of the proband, as were high serum antibody titers to P. gingivalis in the mother and to C. rectus in the unaffected sister compared to the non-periodontitis affected subjects. The proband also showed enhanced neutrophil chemotaxis; a high percentage of pan-B cells; and high productivity of IL-6, IgG, and IgM compared to individuals who were not periodontally affected. The mother showed slightly low helper/induced T cells (Th/i) suppressor/cytotoxic T cells (Ts/c) ratios due to the elevated count of Ts/c, and high IFN-gamma productivity compared to control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - Extensive clinical, microbiological, hematological, and immunological studies were performed on a patient with early onset periodontitis (EOP) and two other members of the family. The proband, a 27-year-old female, had early onset periodontitis and a high level of serum rheumatoid factors (RF) with no diagnosable medical disease. Her mother had lost all her teeth at the age of 50 because of advanced periodontitis, while her elder sister was unaffected by periodontitis. Neither the proband's periodontally-affected mother nor her unaffected sister exhibited a detectable level of RF. In this study, we examined: 1) serum immunoglobulin G (IgG) antibody titers against putative periodontal pathogenic bacteria; 2) peripheral neutrophil functions; 3) phenotypic analyses of peripheral lymphocyte subpopulations; and 4) peripheral lymphocyte functions (T cell proliferative activity, ability of cytokine [interleukin (IL)-2, tumor necrosis factor-alpha, interferon-gamma, IL-6 and IL-8] and IgG and IgM productivity). High antibody titers to Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Campylobacter rectus were detected in the sera of the proband, as were high serum antibody titers to P. gingivalis in the mother and to C. rectus in the unaffected sister compared to the non-periodontitis affected subjects. The proband also showed enhanced neutrophil chemotaxis; a high percentage of pan-B cells; and high productivity of IL-6, IgG, and IgM compared to individuals who were not periodontally affected. The mother showed slightly low helper/induced T cells (Th/i) suppressor/cytotoxic T cells (Ts/c) ratios due to the elevated count of Ts/c, and high IFN-gamma productivity compared to control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

UR - http://www.scopus.com/inward/record.url?scp=0029298640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029298640&partnerID=8YFLogxK

M3 - Article

C2 - 7623261

AN - SCOPUS:0029298640

VL - 66

SP - 403

EP - 412

JO - Journal of Periodontology

JF - Journal of Periodontology

SN - 0022-3492

IS - 5

ER -