Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

Takako Miyamura, Hiroshi Moritake, Hideki Nakayama, Shiro Tanaka, Daisuke Tomizawa, Norio Shiba, Akiko M. Saito, Akio Tawa, Akira Shimada, Shotaro Iwamoto, Yasuhide Hayashi, Takashi Koike, Keizo Horibe, Atsushi Manabe, Shuki Mizutani, Takashi Taga, Souichi Adachi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.

Original languageEnglish
Pages (from-to)284-288
Number of pages5
JournalBritish Journal of Haematology
Volume185
Issue number2
DOIs
Publication statusPublished - Apr 2019
Externally publishedYes

Keywords

  • acute myeloid leukaemia
  • childhood
  • genetic alteration
  • haematopoietic stem cell transplantation
  • primary induction failure

ASJC Scopus subject areas

  • Hematology

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    Miyamura, T., Moritake, H., Nakayama, H., Tanaka, S., Tomizawa, D., Shiba, N., Saito, A. M., Tawa, A., Shimada, A., Iwamoto, S., Hayashi, Y., Koike, T., Horibe, K., Manabe, A., Mizutani, S., Taga, T., & Adachi, S. (2019). Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. British Journal of Haematology, 185(2), 284-288. https://doi.org/10.1111/bjh.15799