Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

Takako Miyamura, Hiroshi Moritake, Hideki Nakayama, Shiro Tanaka, Daisuke Tomizawa, Norio Shiba, Akiko M. Saito, Akio Tawa, Akira Shimada, Shotaro Iwamoto, Yasuhide Hayashi, Takashi Koike, Keizo Horibe, Atsushi Manabe, Shuki Mizutani, Takashi Taga, Souichi Adachi

Research output: Contribution to journalArticle

Abstract

The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.

Original languageEnglish
JournalBritish Journal of Haematology
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Acute Myeloid Leukemia
Lymphoma
Leukemia
Pediatrics
Leukocyte Count
Survival Rate
Therapeutics

Keywords

  • acute myeloid leukaemia
  • childhood
  • genetic alteration
  • haematopoietic stem cell transplantation
  • primary induction failure

ASJC Scopus subject areas

  • Hematology

Cite this

Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. / Miyamura, Takako; Moritake, Hiroshi; Nakayama, Hideki; Tanaka, Shiro; Tomizawa, Daisuke; Shiba, Norio; Saito, Akiko M.; Tawa, Akio; Shimada, Akira; Iwamoto, Shotaro; Hayashi, Yasuhide; Koike, Takashi; Horibe, Keizo; Manabe, Atsushi; Mizutani, Shuki; Taga, Takashi; Adachi, Souichi.

In: British Journal of Haematology, 01.01.2019.

Research output: Contribution to journalArticle

Miyamura, T, Moritake, H, Nakayama, H, Tanaka, S, Tomizawa, D, Shiba, N, Saito, AM, Tawa, A, Shimada, A, Iwamoto, S, Hayashi, Y, Koike, T, Horibe, K, Manabe, A, Mizutani, S, Taga, T & Adachi, S 2019, 'Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study', British Journal of Haematology. https://doi.org/10.1111/bjh.15799
Miyamura, Takako ; Moritake, Hiroshi ; Nakayama, Hideki ; Tanaka, Shiro ; Tomizawa, Daisuke ; Shiba, Norio ; Saito, Akiko M. ; Tawa, Akio ; Shimada, Akira ; Iwamoto, Shotaro ; Hayashi, Yasuhide ; Koike, Takashi ; Horibe, Keizo ; Manabe, Atsushi ; Mizutani, Shuki ; Taga, Takashi ; Adachi, Souichi. / Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. In: British Journal of Haematology. 2019.
@article{a6d6b97ad30b4ac1b197248c4d0143b2,
title = "Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study",
abstract = "The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0{\%}. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.",
keywords = "acute myeloid leukaemia, childhood, genetic alteration, haematopoietic stem cell transplantation, primary induction failure",
author = "Takako Miyamura and Hiroshi Moritake and Hideki Nakayama and Shiro Tanaka and Daisuke Tomizawa and Norio Shiba and Saito, {Akiko M.} and Akio Tawa and Akira Shimada and Shotaro Iwamoto and Yasuhide Hayashi and Takashi Koike and Keizo Horibe and Atsushi Manabe and Shuki Mizutani and Takashi Taga and Souichi Adachi",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/bjh.15799",
language = "English",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

AU - Miyamura, Takako

AU - Moritake, Hiroshi

AU - Nakayama, Hideki

AU - Tanaka, Shiro

AU - Tomizawa, Daisuke

AU - Shiba, Norio

AU - Saito, Akiko M.

AU - Tawa, Akio

AU - Shimada, Akira

AU - Iwamoto, Shotaro

AU - Hayashi, Yasuhide

AU - Koike, Takashi

AU - Horibe, Keizo

AU - Manabe, Atsushi

AU - Mizutani, Shuki

AU - Taga, Takashi

AU - Adachi, Souichi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.

AB - The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.

KW - acute myeloid leukaemia

KW - childhood

KW - genetic alteration

KW - haematopoietic stem cell transplantation

KW - primary induction failure

UR - http://www.scopus.com/inward/record.url?scp=85061905287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061905287&partnerID=8YFLogxK

U2 - 10.1111/bjh.15799

DO - 10.1111/bjh.15799

M3 - Article

C2 - 30784060

AN - SCOPUS:85061905287

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

ER -