@article{a6d6b97ad30b4ac1b197248c4d0143b2,
title = "Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study",
abstract = "The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.",
keywords = "acute myeloid leukaemia, childhood, genetic alteration, haematopoietic stem cell transplantation, primary induction failure",
author = "Takako Miyamura and Hiroshi Moritake and Hideki Nakayama and Shiro Tanaka and Daisuke Tomizawa and Norio Shiba and Saito, {Akiko M.} and Akio Tawa and Akira Shimada and Shotaro Iwamoto and Yasuhide Hayashi and Takashi Koike and Keizo Horibe and Atsushi Manabe and Shuki Mizutani and Takashi Taga and Souichi Adachi",
note = "Funding Information: We thank all the current and past members of the JPLSG AML committee, all the collaborators in the JPLSG central laboratories, all staff at the JPLSG central office, OSCR data centre, and especially all the individual institutes and patients registered in the AML-05 study. This study was supported by a grant-in aid for cancer research and a grant for clinical cancer research from the Ministry of Health, Labour and Welfare, Japan, and the Japan Agency for Medical Research and Development (18ck0106329h0002, 18ck0106461h0001, 18lk0201061t0003), and a grant-in-aid for Clinical Research from Miyazaki University Hospital. Publisher Copyright: {\textcopyright} 2019 British Society for Haematology and John Wiley & Sons Ltd",
year = "2019",
month = apr,
doi = "10.1111/bjh.15799",
language = "English",
volume = "185",
pages = "284--288",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "2",
}