Abstract
The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.
| Original language | English |
|---|---|
| Journal | British Journal of Haematology |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- acute myeloid leukaemia
- childhood
- genetic alteration
- haematopoietic stem cell transplantation
- primary induction failure
ASJC Scopus subject areas
- Hematology
Cite this
Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. / Miyamura, Takako; Moritake, Hiroshi; Nakayama, Hideki; Tanaka, Shiro; Tomizawa, Daisuke; Shiba, Norio; Saito, Akiko M.; Tawa, Akio; Shimada, Akira; Iwamoto, Shotaro; Hayashi, Yasuhide; Koike, Takashi; Horibe, Keizo; Manabe, Atsushi; Mizutani, Shuki; Taga, Takashi; Adachi, Souichi.
In: British Journal of Haematology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study
AU - Miyamura, Takako
AU - Moritake, Hiroshi
AU - Nakayama, Hideki
AU - Tanaka, Shiro
AU - Tomizawa, Daisuke
AU - Shiba, Norio
AU - Saito, Akiko M.
AU - Tawa, Akio
AU - Shimada, Akira
AU - Iwamoto, Shotaro
AU - Hayashi, Yasuhide
AU - Koike, Takashi
AU - Horibe, Keizo
AU - Manabe, Atsushi
AU - Mizutani, Shuki
AU - Taga, Takashi
AU - Adachi, Souichi
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.
AB - The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.
KW - acute myeloid leukaemia
KW - childhood
KW - genetic alteration
KW - haematopoietic stem cell transplantation
KW - primary induction failure
UR - http://www.scopus.com/inward/record.url?scp=85061905287&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061905287&partnerID=8YFLogxK
U2 - 10.1111/bjh.15799
DO - 10.1111/bjh.15799
M3 - Article
C2 - 30784060
AN - SCOPUS:85061905287
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
ER -