Clinical and Bacteriological Evaluation of Branhamella catarrhalis in Respiratory Infections

Atsushi Saito, Keizo Yamaguchi, Yoshiteru Shigeno, Shigeru Kohno, Hideaki Shigeno, Nobuchika Kusano, Yasumasa Dotsu, Kohei Hara

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The clinical significance of Branhamella catarrhalis in respiratory infections is evaluated. 175 strains were isolated, mainly from the sputum, in 71 patients with respiratory infections. B. catarrhalis was most frequently isolated in mixed infections with Haemophilus influenzae 38.3%, H. influenzae plus Streptococcus pneumoniae (10.3%) or S. pneumoniae (9.7%). The rate of isolation of B. catarrhalis alone was as low as 5.1% and from mixed infections with Pseudomonas aeruginosa, Escherichia coli, and Enterobacter and/or Klebsiella species it was 36.6%. More than 107 cfu/ml of B. catarrhalis were isolated from 71.4% of cases. In 29 cases the organism was determined to be causative according to our criteria, most often in secondary infections in patients with complicated pneumoconiosis, chronic bronchitis and bronchiectasis. 29 of 47 strains (61.7%) produced β-lactamase of the penicillinase type. Against these strains, penicillin antibiotics and first and second generation cephalosporin antibiotics (except cefroxadine) showed weak activity compared with their activity against non-β-lactamase- producing strains. The third generation cephalosporins showed a uniform spectrum of activity against both groups of organisms.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalDrugs
Volume31
Issue number3
DOIs
Publication statusPublished - 1986
Externally publishedYes

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Moraxella (Branhamella) catarrhalis
Cephalosporins
Respiratory Tract Infections
Coinfection
Penicillinase
Haemophilus influenzae
Streptococcus pneumoniae
Penicillins
Escherichia coli
Pneumoconiosis
Enterobacter
Bronchiectasis
Klebsiella
Chronic Bronchitis
Sputum
Pseudomonas aeruginosa
cefroxadine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Clinical and Bacteriological Evaluation of Branhamella catarrhalis in Respiratory Infections. / Saito, Atsushi; Yamaguchi, Keizo; Shigeno, Yoshiteru; Kohno, Shigeru; Shigeno, Hideaki; Kusano, Nobuchika; Dotsu, Yasumasa; Hara, Kohei.

In: Drugs, Vol. 31, No. 3, 1986, p. 87-92.

Research output: Contribution to journalArticle

Saito, A, Yamaguchi, K, Shigeno, Y, Kohno, S, Shigeno, H, Kusano, N, Dotsu, Y & Hara, K 1986, 'Clinical and Bacteriological Evaluation of Branhamella catarrhalis in Respiratory Infections', Drugs, vol. 31, no. 3, pp. 87-92. https://doi.org/10.2165/00003495-198600313-00019
Saito, Atsushi ; Yamaguchi, Keizo ; Shigeno, Yoshiteru ; Kohno, Shigeru ; Shigeno, Hideaki ; Kusano, Nobuchika ; Dotsu, Yasumasa ; Hara, Kohei. / Clinical and Bacteriological Evaluation of Branhamella catarrhalis in Respiratory Infections. In: Drugs. 1986 ; Vol. 31, No. 3. pp. 87-92.
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