Clathrin-mediated endocytosis: Membrane factors pull the trigger

Kohji Takei, Volker Haucke

Research output: Contribution to journalReview articlepeer-review

237 Citations (Scopus)


Clathrin-mediated endocytosis is a vesicular transport event involved in the internalization and recycling of receptors participating in signal transduction events and nutrient import as well as in the reformation of synaptic vesicles. Recent studies in vitro and in living cells have provided a number of new insights into the initial steps of clathrin-coated vesicle formation and the membrane factors involved in this process. The unexpected complexity of these interactions at the cytosol-membrane interface suggests that clathrin-coated vesicle assembly is a highly cooperative process occurring under tight regulatory control. In this review, we focus on the role of membrane proteins and lipids in the nucleation of clathrin-coated pits and provide a hypothetical model for the early steps in clathrin-mediated endocytosis.

Original languageEnglish
Pages (from-to)385-391
Number of pages7
JournalTrends in Cell Biology
Issue number9
Publication statusPublished - Sept 1 2001

ASJC Scopus subject areas

  • Cell Biology


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