Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma

J. Qi; J. Wang; H. Katayama; S. Sen; S. M. Liu

doi:10.4149/neo_2013_018

Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma

J. Qi, J. Wang, H. Katayama, S. Sen, S. M. Liu

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

Incidence and mortality associated with hepatocellular carcinoma (HCC) is rising throughout the world. Accurate, noninvasive biomarkers for the early detection of HCC are urgently needed to reduce worldwide morbidity and mortality related to HCC. MicroRNAs (miRNAs), 17- to 25-nucleotide noncoding RNAs that are frequently dysregulated in HCC, have shown great promise as tissue-based markers for HCC diagnosis and prognosis. Moreover, they are stably expressed in serum and urine, and these circulating microRNAs (cmiRNAs) are emerging as novel noninvasive biomarkers for the early detection and prognosis of HCC. This article summarizes the latest findings on the role of circulating miRNAs as potential minimally invasive diagnostic and prognostic biomarkers for HCC.

Original language	English
Pages (from-to)	135-142
Number of pages	8
Journal	Neoplasma
Volume	60
Issue number	2
DOIs	https://doi.org/10.4149/neo_2013_018
Publication status	Published - 2013
Externally published	Yes

Keywords

Biomarkers
Circulating microRNAs (cmiRNAs)
Diagnosis and prognosis
HCC

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4149/neo_2013_018

Cite this

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title = "Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma",

abstract = "Incidence and mortality associated with hepatocellular carcinoma (HCC) is rising throughout the world. Accurate, noninvasive biomarkers for the early detection of HCC are urgently needed to reduce worldwide morbidity and mortality related to HCC. MicroRNAs (miRNAs), 17- to 25-nucleotide noncoding RNAs that are frequently dysregulated in HCC, have shown great promise as tissue-based markers for HCC diagnosis and prognosis. Moreover, they are stably expressed in serum and urine, and these circulating microRNAs (cmiRNAs) are emerging as novel noninvasive biomarkers for the early detection and prognosis of HCC. This article summarizes the latest findings on the role of circulating miRNAs as potential minimally invasive diagnostic and prognostic biomarkers for HCC.",

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T1 - Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma

AU - Qi, J.

AU - Wang, J.

AU - Katayama, H.

AU - Sen, S.

AU - Liu, S. M.

PY - 2013

Y1 - 2013

N2 - Incidence and mortality associated with hepatocellular carcinoma (HCC) is rising throughout the world. Accurate, noninvasive biomarkers for the early detection of HCC are urgently needed to reduce worldwide morbidity and mortality related to HCC. MicroRNAs (miRNAs), 17- to 25-nucleotide noncoding RNAs that are frequently dysregulated in HCC, have shown great promise as tissue-based markers for HCC diagnosis and prognosis. Moreover, they are stably expressed in serum and urine, and these circulating microRNAs (cmiRNAs) are emerging as novel noninvasive biomarkers for the early detection and prognosis of HCC. This article summarizes the latest findings on the role of circulating miRNAs as potential minimally invasive diagnostic and prognostic biomarkers for HCC.

AB - Incidence and mortality associated with hepatocellular carcinoma (HCC) is rising throughout the world. Accurate, noninvasive biomarkers for the early detection of HCC are urgently needed to reduce worldwide morbidity and mortality related to HCC. MicroRNAs (miRNAs), 17- to 25-nucleotide noncoding RNAs that are frequently dysregulated in HCC, have shown great promise as tissue-based markers for HCC diagnosis and prognosis. Moreover, they are stably expressed in serum and urine, and these circulating microRNAs (cmiRNAs) are emerging as novel noninvasive biomarkers for the early detection and prognosis of HCC. This article summarizes the latest findings on the role of circulating miRNAs as potential minimally invasive diagnostic and prognostic biomarkers for HCC.

KW - Biomarkers

KW - Circulating microRNAs (cmiRNAs)

KW - Diagnosis and prognosis

KW - HCC

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Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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