Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma

J. Qi, J. Wang, Hiroshi Katayama, S. Sen, S. M. Liu

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Incidence and mortality associated with hepatocellular carcinoma (HCC) is rising throughout the world. Accurate, noninvasive biomarkers for the early detection of HCC are urgently needed to reduce worldwide morbidity and mortality related to HCC. MicroRNAs (miRNAs), 17- to 25-nucleotide noncoding RNAs that are frequently dysregulated in HCC, have shown great promise as tissue-based markers for HCC diagnosis and prognosis. Moreover, they are stably expressed in serum and urine, and these circulating microRNAs (cmiRNAs) are emerging as novel noninvasive biomarkers for the early detection and prognosis of HCC. This article summarizes the latest findings on the role of circulating miRNAs as potential minimally invasive diagnostic and prognostic biomarkers for HCC.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalNeoplasma
Volume60
Issue number2
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

MicroRNAs
Hepatocellular Carcinoma
Biomarkers
Untranslated RNA
Mortality
Nucleotides
Urine
Morbidity
Incidence
Serum

Keywords

  • Biomarkers
  • Circulating microRNAs (cmiRNAs)
  • Diagnosis and prognosis
  • HCC

ASJC Scopus subject areas

  • Cancer Research

Cite this

Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma. / Qi, J.; Wang, J.; Katayama, Hiroshi; Sen, S.; Liu, S. M.

In: Neoplasma, Vol. 60, No. 2, 2013, p. 135-142.

Research output: Contribution to journalArticle

Qi, J. ; Wang, J. ; Katayama, Hiroshi ; Sen, S. ; Liu, S. M. / Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma. In: Neoplasma. 2013 ; Vol. 60, No. 2. pp. 135-142.
@article{ecff907fb55a4584b8fdfd57b689cf03,
title = "Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma",
abstract = "Incidence and mortality associated with hepatocellular carcinoma (HCC) is rising throughout the world. Accurate, noninvasive biomarkers for the early detection of HCC are urgently needed to reduce worldwide morbidity and mortality related to HCC. MicroRNAs (miRNAs), 17- to 25-nucleotide noncoding RNAs that are frequently dysregulated in HCC, have shown great promise as tissue-based markers for HCC diagnosis and prognosis. Moreover, they are stably expressed in serum and urine, and these circulating microRNAs (cmiRNAs) are emerging as novel noninvasive biomarkers for the early detection and prognosis of HCC. This article summarizes the latest findings on the role of circulating miRNAs as potential minimally invasive diagnostic and prognostic biomarkers for HCC.",
keywords = "Biomarkers, Circulating microRNAs (cmiRNAs), Diagnosis and prognosis, HCC",
author = "J. Qi and J. Wang and Hiroshi Katayama and S. Sen and Liu, {S. M.}",
year = "2013",
doi = "10.4149/neo_2013_018",
language = "English",
volume = "60",
pages = "135--142",
journal = "Neoplasma",
issn = "0028-2685",
publisher = "Vydavatel'stvo Slovenkej Akademie Vied/Veda Publishing House of the Slovak Academy of Sciences",
number = "2",

}

TY - JOUR

T1 - Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma

AU - Qi, J.

AU - Wang, J.

AU - Katayama, Hiroshi

AU - Sen, S.

AU - Liu, S. M.

PY - 2013

Y1 - 2013

N2 - Incidence and mortality associated with hepatocellular carcinoma (HCC) is rising throughout the world. Accurate, noninvasive biomarkers for the early detection of HCC are urgently needed to reduce worldwide morbidity and mortality related to HCC. MicroRNAs (miRNAs), 17- to 25-nucleotide noncoding RNAs that are frequently dysregulated in HCC, have shown great promise as tissue-based markers for HCC diagnosis and prognosis. Moreover, they are stably expressed in serum and urine, and these circulating microRNAs (cmiRNAs) are emerging as novel noninvasive biomarkers for the early detection and prognosis of HCC. This article summarizes the latest findings on the role of circulating miRNAs as potential minimally invasive diagnostic and prognostic biomarkers for HCC.

AB - Incidence and mortality associated with hepatocellular carcinoma (HCC) is rising throughout the world. Accurate, noninvasive biomarkers for the early detection of HCC are urgently needed to reduce worldwide morbidity and mortality related to HCC. MicroRNAs (miRNAs), 17- to 25-nucleotide noncoding RNAs that are frequently dysregulated in HCC, have shown great promise as tissue-based markers for HCC diagnosis and prognosis. Moreover, they are stably expressed in serum and urine, and these circulating microRNAs (cmiRNAs) are emerging as novel noninvasive biomarkers for the early detection and prognosis of HCC. This article summarizes the latest findings on the role of circulating miRNAs as potential minimally invasive diagnostic and prognostic biomarkers for HCC.

KW - Biomarkers

KW - Circulating microRNAs (cmiRNAs)

KW - Diagnosis and prognosis

KW - HCC

UR - http://www.scopus.com/inward/record.url?scp=84878793883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878793883&partnerID=8YFLogxK

U2 - 10.4149/neo_2013_018

DO - 10.4149/neo_2013_018

M3 - Article

VL - 60

SP - 135

EP - 142

JO - Neoplasma

JF - Neoplasma

SN - 0028-2685

IS - 2

ER -