Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis

Hisashi Masuyama, Naoko Suwaki, Hideki Nakatsukasa, Akio Masumoto, Yoko Tateishi, Yuji Hiramatrsu

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Objective: Recently, reports have indicated that the imbalance of circulating angiogenic factors is important in the onset of preeclampsia. In this study we investigated angiogenic factor levels in women with preeclampsia, preeclampsia superimposed on chronic glomerulonephritis, gestational proteinuria, and normal pregnancies. Study design: We measured several circulating angiogenic factors, placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase-1, and soluble fetal liver kinase-1. Results: Compared with women with normal pregnancies, placental growth factor concentrations were lower, and soluble fms-like tyrosine kinase 1 concentrations were higher in women with preeclampsia and gestational proteinuria; soluble fms-like tyrosine kinase 1 concentrations were also higher in women with preeclampsia superimposed on chronic glomerulonephritis. Conclusion: There were obvious differences in the levels of circulating angiogenic factors placental growth factor and soluble fms-like tyrosine kinase 1 among preeclampsia, gestational proteinuria, and controls. The imbalance of angiogenic factors is important in the onset of preeclampsia superimposed on chronic glomerulonephritis.

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume194
Issue number2
DOIs
Publication statusPublished - Feb 1 2006

Keywords

  • Angiogenic factor
  • Gestational proteinuria
  • Preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis'. Together they form a unique fingerprint.

  • Cite this