Chronic treatment with imipramine and lithium increases cell proliferation in the hippocampus in adrenocorticotropic hormone-treated rats

Yoshihisa Kitamura, Maho Doi, Keiko Kuwatsuka, Yuka Onoue, Ikuko Miyazaki, Kazuaki Shinomiya, Toshihiro Koyama, Toshiaki Sendo, Hiromu Kawasaki, Masato Asanuma, Yutaka Gomita

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Adult hippocampal neurogenesis is reported to change in animal models of depression and antidepressants. We have used the mitotic marker 5-bromo-2'-deoxyyridine to address the effects of imipramine and lithium on cell proliferation and survival following chronic treatment with adrenocorticotropic hormone (ACTH) in the subgranular zone of the hippocampal dentate gyrus. ACTH treatment for 14 d decreased adult hippocampal cell proliferation and survival. Coadministration of imipramine and lithium for 14 d blocked the loss of cell proliferation but not cell survival resulting from the chronic treatment with ACTH. The coadministration of imipramine and lithium may have treatment-resistant antidepressive properties, which may be attributed, in part, to a normalization of hippocampal cell proliferation.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume34
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • 5-bromo-2′-deoxyyridine
  • Adrenocorticotropic hormone
  • Cell proliferation
  • Imipramine
  • Lithium

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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