Chronic lymphoproliferative disorder with regulatory T-cell phenotype

Tomoko Kikuchi, Yoshio Katayama, Shiro Kubonishi, Toshiyuki Watanabe, Yukari Watanabe, Ken Ichi Matsuoka, Yoshinobu Maeda, Noriko Namba, Taro Masunari, Ryusuke Nasu, Kazuma Ikeda, Mitsune Tanimoto

Research output: Contribution to journalArticle


We report a case of T-cell chronic lymphoproliferative disorder (CLPD) that shows neither features of T-cell prolymphocytic leukemia nor disease progression for more than 34 months. Flow cytometric analyses of the lymphocytes revealed high expression of CD4 and CD25. Up-regulation of Foxp3, a master regulatory gene for developmental differentiation of regulatory T cells (Treg), was confirmed at mRNA and protein levels. To our knowledge, this is the first case of extremely indolent CLPD with Treg phenotype.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalAmerican Journal of Hematology
Issue number9
Publication statusPublished - Sep 2006


  • Chronic lymphoproliferative disorder
  • Foxp3
  • Regulatory T cells

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Kikuchi, T., Katayama, Y., Kubonishi, S., Watanabe, T., Watanabe, Y., Matsuoka, K. I., Maeda, Y., Namba, N., Masunari, T., Nasu, R., Ikeda, K., & Tanimoto, M. (2006). Chronic lymphoproliferative disorder with regulatory T-cell phenotype. American Journal of Hematology, 81(9), 713-716.