Chronic lymphoproliferative disorder with regulatory T-cell phenotype

Tomoko Kikuchi, Yoshio Katayama, Shiro Kubonishi, Toshiyuki Watanabe, Yukari Watanabe, Ken-ichi Matsuoka, Yoshinobu Maeda, Noriko Namba, Taro Masunari, Ryusuke Nasu, Kazuma Ikeda, Mitsune Tanimoto

Research output: Contribution to journalArticle

Abstract

We report a case of T-cell chronic lymphoproliferative disorder (CLPD) that shows neither features of T-cell prolymphocytic leukemia nor disease progression for more than 34 months. Flow cytometric analyses of the lymphocytes revealed high expression of CD4 and CD25. Up-regulation of Foxp3, a master regulatory gene for developmental differentiation of regulatory T cells (Treg), was confirmed at mRNA and protein levels. To our knowledge, this is the first case of extremely indolent CLPD with Treg phenotype.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalAmerican Journal of Hematology
Volume81
Issue number9
DOIs
Publication statusPublished - Sep 2006

Fingerprint

Lymphoproliferative Disorders
Regulatory T-Lymphocytes
T-Cell Prolymphocytic Leukemia
Phenotype
Regulator Genes
Disease Progression
Up-Regulation
Lymphocytes
T-Lymphocytes
Messenger RNA
Proteins

Keywords

  • Chronic lymphoproliferative disorder
  • Foxp3
  • Regulatory T cells

ASJC Scopus subject areas

  • Hematology

Cite this

Kikuchi, T., Katayama, Y., Kubonishi, S., Watanabe, T., Watanabe, Y., Matsuoka, K., ... Tanimoto, M. (2006). Chronic lymphoproliferative disorder with regulatory T-cell phenotype. American Journal of Hematology, 81(9), 713-716. https://doi.org/10.1002/ajh.20688

Chronic lymphoproliferative disorder with regulatory T-cell phenotype. / Kikuchi, Tomoko; Katayama, Yoshio; Kubonishi, Shiro; Watanabe, Toshiyuki; Watanabe, Yukari; Matsuoka, Ken-ichi; Maeda, Yoshinobu; Namba, Noriko; Masunari, Taro; Nasu, Ryusuke; Ikeda, Kazuma; Tanimoto, Mitsune.

In: American Journal of Hematology, Vol. 81, No. 9, 09.2006, p. 713-716.

Research output: Contribution to journalArticle

Kikuchi, T, Katayama, Y, Kubonishi, S, Watanabe, T, Watanabe, Y, Matsuoka, K, Maeda, Y, Namba, N, Masunari, T, Nasu, R, Ikeda, K & Tanimoto, M 2006, 'Chronic lymphoproliferative disorder with regulatory T-cell phenotype', American Journal of Hematology, vol. 81, no. 9, pp. 713-716. https://doi.org/10.1002/ajh.20688
Kikuchi, Tomoko ; Katayama, Yoshio ; Kubonishi, Shiro ; Watanabe, Toshiyuki ; Watanabe, Yukari ; Matsuoka, Ken-ichi ; Maeda, Yoshinobu ; Namba, Noriko ; Masunari, Taro ; Nasu, Ryusuke ; Ikeda, Kazuma ; Tanimoto, Mitsune. / Chronic lymphoproliferative disorder with regulatory T-cell phenotype. In: American Journal of Hematology. 2006 ; Vol. 81, No. 9. pp. 713-716.
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