Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) with limbic encephalitis

Yasuyuki Ohta, Emi Nomura, Keiichiro Tsunoda, Toru Yamashita, Yoshiaki Takahashi, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

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2 Citations (Scopus)

Abstract

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIP-PERS) is an inflammatory central nervous system disorder that mainly involves in the brainstem, basal ganglia and cerebellum. We herein report the case of a patient with CLIPPERS, which was diagnosed based on the clinical and radiological features. After initially responded to steroid treatment, the patient developed limbic encephalitis. The patient presented with memory disturbance, a delirious state and emotional incontinence. A cerebrospinal fluid study revealed interleukin-6 elevation and enhanced bilateral hippocampal lesions were observed on MRI. The patient was successfully treated with methylprednisolone pulse therapy. This is the first case of CLIPPERS with limbic encephalitis involving the bilateral hippocampus.

Original languageEnglish
Pages (from-to)2513-2518
Number of pages6
JournalInternal Medicine
Volume56
Issue number18
DOIs
Publication statusPublished - 2017

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Keywords

  • CLIPPERS
  • Hippocampus
  • IL-6
  • Limbic encephalitis
  • Meningoencephalitis
  • MRI

ASJC Scopus subject areas

  • Internal Medicine

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