Chronic lisuride hydrogen maleate administration enhances muscarinic receptor binding in senescent rat brain

H. Hirata, N. Ogawa, K. Mizukawa, K. Haba, Masato Asanuma, A. Mori, Z. Ota

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Changes in the regional density of muscarinic-1 (M1) receptors and the effect of lisuride hydrogen maleate on these changes were studied in senescent rat brain by in vitro autoradiography. In young adult controls, M1 receptor binding was most dense in the striatum and hippocampus, followed by the cerebral cortex and amygdala. Binding to M1 receptors was markedly lower in these areas of the senescent brain compared with the young adult brain. These decreases were reversed by intraperitoneal administration of 50μg/kg day lisuride for 14 days. The present results indicate that the therapeutic efficacy of lisuride depends on normalization of not only monoamine systems but also acetylcholine systems.

Original languageEnglish
Pages (from-to)318-325
Number of pages8
JournalJournal of International Medical Research
Volume19
Issue number4
Publication statusPublished - 1991

Fingerprint

Lisuride
Muscarinic Receptors
Cholinergic Agents
Rats
Brain
Young Adult
Amygdala
Autoradiography
Cerebral Cortex
Acetylcholine
Hippocampus
maleic acid
Therapeutics

Keywords

  • Acetylcholine neuronal system
  • Lisuride hydrogen maleate
  • Muscarinic receptor
  • Pirenzepine
  • Senescent rat Receptor autoradiography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chronic lisuride hydrogen maleate administration enhances muscarinic receptor binding in senescent rat brain. / Hirata, H.; Ogawa, N.; Mizukawa, K.; Haba, K.; Asanuma, Masato; Mori, A.; Ota, Z.

In: Journal of International Medical Research, Vol. 19, No. 4, 1991, p. 318-325.

Research output: Contribution to journalArticle

Hirata, H. ; Ogawa, N. ; Mizukawa, K. ; Haba, K. ; Asanuma, Masato ; Mori, A. ; Ota, Z. / Chronic lisuride hydrogen maleate administration enhances muscarinic receptor binding in senescent rat brain. In: Journal of International Medical Research. 1991 ; Vol. 19, No. 4. pp. 318-325.
@article{d48af2e029dc42d6bd26f48089ff8973,
title = "Chronic lisuride hydrogen maleate administration enhances muscarinic receptor binding in senescent rat brain",
abstract = "Changes in the regional density of muscarinic-1 (M1) receptors and the effect of lisuride hydrogen maleate on these changes were studied in senescent rat brain by in vitro autoradiography. In young adult controls, M1 receptor binding was most dense in the striatum and hippocampus, followed by the cerebral cortex and amygdala. Binding to M1 receptors was markedly lower in these areas of the senescent brain compared with the young adult brain. These decreases were reversed by intraperitoneal administration of 50μg/kg day lisuride for 14 days. The present results indicate that the therapeutic efficacy of lisuride depends on normalization of not only monoamine systems but also acetylcholine systems.",
keywords = "Acetylcholine neuronal system, Lisuride hydrogen maleate, Muscarinic receptor, Pirenzepine, Senescent rat Receptor autoradiography",
author = "H. Hirata and N. Ogawa and K. Mizukawa and K. Haba and Masato Asanuma and A. Mori and Z. Ota",
year = "1991",
language = "English",
volume = "19",
pages = "318--325",
journal = "Journal of International Medical Research",
issn = "0300-0605",
publisher = "Field House Publishing LLP",
number = "4",

}

TY - JOUR

T1 - Chronic lisuride hydrogen maleate administration enhances muscarinic receptor binding in senescent rat brain

AU - Hirata, H.

AU - Ogawa, N.

AU - Mizukawa, K.

AU - Haba, K.

AU - Asanuma, Masato

AU - Mori, A.

AU - Ota, Z.

PY - 1991

Y1 - 1991

N2 - Changes in the regional density of muscarinic-1 (M1) receptors and the effect of lisuride hydrogen maleate on these changes were studied in senescent rat brain by in vitro autoradiography. In young adult controls, M1 receptor binding was most dense in the striatum and hippocampus, followed by the cerebral cortex and amygdala. Binding to M1 receptors was markedly lower in these areas of the senescent brain compared with the young adult brain. These decreases were reversed by intraperitoneal administration of 50μg/kg day lisuride for 14 days. The present results indicate that the therapeutic efficacy of lisuride depends on normalization of not only monoamine systems but also acetylcholine systems.

AB - Changes in the regional density of muscarinic-1 (M1) receptors and the effect of lisuride hydrogen maleate on these changes were studied in senescent rat brain by in vitro autoradiography. In young adult controls, M1 receptor binding was most dense in the striatum and hippocampus, followed by the cerebral cortex and amygdala. Binding to M1 receptors was markedly lower in these areas of the senescent brain compared with the young adult brain. These decreases were reversed by intraperitoneal administration of 50μg/kg day lisuride for 14 days. The present results indicate that the therapeutic efficacy of lisuride depends on normalization of not only monoamine systems but also acetylcholine systems.

KW - Acetylcholine neuronal system

KW - Lisuride hydrogen maleate

KW - Muscarinic receptor

KW - Pirenzepine

KW - Senescent rat Receptor autoradiography

UR - http://www.scopus.com/inward/record.url?scp=0025784225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025784225&partnerID=8YFLogxK

M3 - Article

C2 - 1916005

AN - SCOPUS:0025784225

VL - 19

SP - 318

EP - 325

JO - Journal of International Medical Research

JF - Journal of International Medical Research

SN - 0300-0605

IS - 4

ER -