Chronic kidney disease is positively and diabetes mellitus is negatively associated with abdominal aortic aneurysm

Hidemi Takeuchi, Michihiro Okuyama, Haruhito Adam Uchida, Yuki Kakio, Ryoko Umebayashi, Yuka Okuyama, Yasuhiro Fujii, Susumu Oozawa, Masashi Yoshida, Yu Oshima, Shunji Sano, Jun Wada

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background and Aims Chronic kidney disease (CKD) and diabetes mellitus (DM) are considered as risk factors for cardiovascular diseases. The purpose of this study was to clarify the relationship of CKD and DM with the presence of abdominal aortic aneurysm (AAA). Methods We enrolled 261 patients with AAA (AAA+) and age-and-sex matched 261 patients without AAA (AAA-) at two hospitals between 2008 and 2014, and examined the association between the risk factors and the presence of AAA. Furthermore, in order to investigate the prevalence of AAA in each group, we enrolled 1126 patients with CKD and 400 patients with DM. Results The presence of CKD in patients with AAA+ was significantly higher than that in patients with AAA- (AAA+; 65%, AAA-; 52%, P = 0.004). The presence of DM in patients with AAA+ was significantly lower than that in patients with AAA- (AAA+; 17%, AAA-; 35%, P < 0.001). A multivariate logistic regression analysis demonstrated that hypertension, ischemic heart disease and CKD were independent determinants, whereas, DM was a negatively independent determinant, for the presence of AAA. The prevalence of AAA in patients with CKD 65 years old and above was 5.1%, whereas, that in patients with DM 65 years old and above was only 0.6%. Conclusion CKD is a positively associated with the presence of AAA. In contrast, DM is a negatively associated with the presence of AAA in Japanese population.

Original languageEnglish
Article numbere0164015
JournalPLoS One
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

Fingerprint

aneurysm
Abdominal Aortic Aneurysm
Medical problems
diabetes mellitus
kidney diseases
Chronic Renal Insufficiency
Diabetes Mellitus
Regression analysis
Logistics
risk factors

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Chronic kidney disease is positively and diabetes mellitus is negatively associated with abdominal aortic aneurysm. / Takeuchi, Hidemi; Okuyama, Michihiro; Uchida, Haruhito Adam; Kakio, Yuki; Umebayashi, Ryoko; Okuyama, Yuka; Fujii, Yasuhiro; Oozawa, Susumu; Yoshida, Masashi; Oshima, Yu; Sano, Shunji; Wada, Jun.

In: PLoS One, Vol. 11, No. 10, e0164015, 01.10.2016.

Research output: Contribution to journalArticle

Takeuchi, Hidemi ; Okuyama, Michihiro ; Uchida, Haruhito Adam ; Kakio, Yuki ; Umebayashi, Ryoko ; Okuyama, Yuka ; Fujii, Yasuhiro ; Oozawa, Susumu ; Yoshida, Masashi ; Oshima, Yu ; Sano, Shunji ; Wada, Jun. / Chronic kidney disease is positively and diabetes mellitus is negatively associated with abdominal aortic aneurysm. In: PLoS One. 2016 ; Vol. 11, No. 10.
@article{95ec8b7a917648df9c0442e8cdbd1c2e,
title = "Chronic kidney disease is positively and diabetes mellitus is negatively associated with abdominal aortic aneurysm",
abstract = "Background and Aims Chronic kidney disease (CKD) and diabetes mellitus (DM) are considered as risk factors for cardiovascular diseases. The purpose of this study was to clarify the relationship of CKD and DM with the presence of abdominal aortic aneurysm (AAA). Methods We enrolled 261 patients with AAA (AAA+) and age-and-sex matched 261 patients without AAA (AAA-) at two hospitals between 2008 and 2014, and examined the association between the risk factors and the presence of AAA. Furthermore, in order to investigate the prevalence of AAA in each group, we enrolled 1126 patients with CKD and 400 patients with DM. Results The presence of CKD in patients with AAA+ was significantly higher than that in patients with AAA- (AAA+; 65{\%}, AAA-; 52{\%}, P = 0.004). The presence of DM in patients with AAA+ was significantly lower than that in patients with AAA- (AAA+; 17{\%}, AAA-; 35{\%}, P < 0.001). A multivariate logistic regression analysis demonstrated that hypertension, ischemic heart disease and CKD were independent determinants, whereas, DM was a negatively independent determinant, for the presence of AAA. The prevalence of AAA in patients with CKD 65 years old and above was 5.1{\%}, whereas, that in patients with DM 65 years old and above was only 0.6{\%}. Conclusion CKD is a positively associated with the presence of AAA. In contrast, DM is a negatively associated with the presence of AAA in Japanese population.",
author = "Hidemi Takeuchi and Michihiro Okuyama and Uchida, {Haruhito Adam} and Yuki Kakio and Ryoko Umebayashi and Yuka Okuyama and Yasuhiro Fujii and Susumu Oozawa and Masashi Yoshida and Yu Oshima and Shunji Sano and Jun Wada",
year = "2016",
month = "10",
day = "1",
doi = "10.1371/journal.pone.0164015",
language = "English",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

TY - JOUR

T1 - Chronic kidney disease is positively and diabetes mellitus is negatively associated with abdominal aortic aneurysm

AU - Takeuchi, Hidemi

AU - Okuyama, Michihiro

AU - Uchida, Haruhito Adam

AU - Kakio, Yuki

AU - Umebayashi, Ryoko

AU - Okuyama, Yuka

AU - Fujii, Yasuhiro

AU - Oozawa, Susumu

AU - Yoshida, Masashi

AU - Oshima, Yu

AU - Sano, Shunji

AU - Wada, Jun

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background and Aims Chronic kidney disease (CKD) and diabetes mellitus (DM) are considered as risk factors for cardiovascular diseases. The purpose of this study was to clarify the relationship of CKD and DM with the presence of abdominal aortic aneurysm (AAA). Methods We enrolled 261 patients with AAA (AAA+) and age-and-sex matched 261 patients without AAA (AAA-) at two hospitals between 2008 and 2014, and examined the association between the risk factors and the presence of AAA. Furthermore, in order to investigate the prevalence of AAA in each group, we enrolled 1126 patients with CKD and 400 patients with DM. Results The presence of CKD in patients with AAA+ was significantly higher than that in patients with AAA- (AAA+; 65%, AAA-; 52%, P = 0.004). The presence of DM in patients with AAA+ was significantly lower than that in patients with AAA- (AAA+; 17%, AAA-; 35%, P < 0.001). A multivariate logistic regression analysis demonstrated that hypertension, ischemic heart disease and CKD were independent determinants, whereas, DM was a negatively independent determinant, for the presence of AAA. The prevalence of AAA in patients with CKD 65 years old and above was 5.1%, whereas, that in patients with DM 65 years old and above was only 0.6%. Conclusion CKD is a positively associated with the presence of AAA. In contrast, DM is a negatively associated with the presence of AAA in Japanese population.

AB - Background and Aims Chronic kidney disease (CKD) and diabetes mellitus (DM) are considered as risk factors for cardiovascular diseases. The purpose of this study was to clarify the relationship of CKD and DM with the presence of abdominal aortic aneurysm (AAA). Methods We enrolled 261 patients with AAA (AAA+) and age-and-sex matched 261 patients without AAA (AAA-) at two hospitals between 2008 and 2014, and examined the association between the risk factors and the presence of AAA. Furthermore, in order to investigate the prevalence of AAA in each group, we enrolled 1126 patients with CKD and 400 patients with DM. Results The presence of CKD in patients with AAA+ was significantly higher than that in patients with AAA- (AAA+; 65%, AAA-; 52%, P = 0.004). The presence of DM in patients with AAA+ was significantly lower than that in patients with AAA- (AAA+; 17%, AAA-; 35%, P < 0.001). A multivariate logistic regression analysis demonstrated that hypertension, ischemic heart disease and CKD were independent determinants, whereas, DM was a negatively independent determinant, for the presence of AAA. The prevalence of AAA in patients with CKD 65 years old and above was 5.1%, whereas, that in patients with DM 65 years old and above was only 0.6%. Conclusion CKD is a positively associated with the presence of AAA. In contrast, DM is a negatively associated with the presence of AAA in Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=84992200290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992200290&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0164015

DO - 10.1371/journal.pone.0164015

M3 - Article

C2 - 27764090

AN - SCOPUS:84992200290

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 10

M1 - e0164015

ER -