Chronic kidney disease is associated with carotid atherosclerosis and symptomatic ischaemic stroke

Nobuo Kajitani, Haruhito Adam Uchida, Isao Suminoe, Yuki Kakio, Masashi Kitagawa, Hajime Sato, Jun Wada

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: We aimed to investigate the relationships among chronic kidney disease (CKD), symptomatic ischaemic stroke, and carotid atherosclerosis. Methods: We enrolled 455 patients who underwent carotid ultrasonography in our hospital, including 311 patients with symptomatic ischaemic stroke and 144 patients without symptomatic ischaemic stroke. Carotid intima–media thickness (IMT), the rate of internal carotid artery stenosis, and maximal plaque size were evaluated. Results: The mean age of the patients was 68.5 ± 11.0 years and the mean estimated glomerular filtration rate (eGFR) was 68.8 ± 18.2 mL/min/1.73 m2. After adjustment for cardiovascular risk factors, the mean IMT was significantly higher in patients with CKD than in those without CKD. The IMT and eGFR were negatively correlated in patients with stroke (r = −0.169). Multiple logistic regression analyses showed that mean IMT, plaque size, and internal carotid artery stenosis were significant determinants of symptomatic ischaemic stroke after adjustment of multivariate risk factors. Furthermore, the eGFR was a negative determinant of symptomatic ischaemic stroke after adjusting for classical risk factors (odds ratio [95% confidence interval] = 0.868 [0.769–0.979]). Conclusion: CKD might be associated with the carotid atherosclerosis and symptomatic ischaemic stroke.

Original languageEnglish
Pages (from-to)3873-3883
Number of pages11
JournalJournal of International Medical Research
Volume46
Issue number9
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

Carotid Artery Diseases
Chronic Renal Insufficiency
Stroke
Glomerular Filtration Rate
Ultrasonography
Carotid Stenosis
Logistics
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals

Keywords

  • carotid atherosclerosis
  • Chronic kidney disease (CKD)
  • glomerular filtration rate (GFR)
  • intima–media thickness (IMT)
  • ischaemic stroke
  • ultrasonography

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

Chronic kidney disease is associated with carotid atherosclerosis and symptomatic ischaemic stroke. / Kajitani, Nobuo; Uchida, Haruhito Adam; Suminoe, Isao; Kakio, Yuki; Kitagawa, Masashi; Sato, Hajime; Wada, Jun.

In: Journal of International Medical Research, Vol. 46, No. 9, 01.09.2018, p. 3873-3883.

Research output: Contribution to journalArticle

@article{6707befd63524861a3e1bdb013ff49f2,
title = "Chronic kidney disease is associated with carotid atherosclerosis and symptomatic ischaemic stroke",
abstract = "Objective: We aimed to investigate the relationships among chronic kidney disease (CKD), symptomatic ischaemic stroke, and carotid atherosclerosis. Methods: We enrolled 455 patients who underwent carotid ultrasonography in our hospital, including 311 patients with symptomatic ischaemic stroke and 144 patients without symptomatic ischaemic stroke. Carotid intima–media thickness (IMT), the rate of internal carotid artery stenosis, and maximal plaque size were evaluated. Results: The mean age of the patients was 68.5 ± 11.0 years and the mean estimated glomerular filtration rate (eGFR) was 68.8 ± 18.2 mL/min/1.73 m2. After adjustment for cardiovascular risk factors, the mean IMT was significantly higher in patients with CKD than in those without CKD. The IMT and eGFR were negatively correlated in patients with stroke (r = −0.169). Multiple logistic regression analyses showed that mean IMT, plaque size, and internal carotid artery stenosis were significant determinants of symptomatic ischaemic stroke after adjustment of multivariate risk factors. Furthermore, the eGFR was a negative determinant of symptomatic ischaemic stroke after adjusting for classical risk factors (odds ratio [95{\%} confidence interval] = 0.868 [0.769–0.979]). Conclusion: CKD might be associated with the carotid atherosclerosis and symptomatic ischaemic stroke.",
keywords = "carotid atherosclerosis, Chronic kidney disease (CKD), glomerular filtration rate (GFR), intima–media thickness (IMT), ischaemic stroke, ultrasonography",
author = "Nobuo Kajitani and Uchida, {Haruhito Adam} and Isao Suminoe and Yuki Kakio and Masashi Kitagawa and Hajime Sato and Jun Wada",
year = "2018",
month = "9",
day = "1",
doi = "10.1177/0300060518781619",
language = "English",
volume = "46",
pages = "3873--3883",
journal = "Journal of International Medical Research",
issn = "0300-0605",
publisher = "Field House Publishing LLP",
number = "9",

}

TY - JOUR

T1 - Chronic kidney disease is associated with carotid atherosclerosis and symptomatic ischaemic stroke

AU - Kajitani, Nobuo

AU - Uchida, Haruhito Adam

AU - Suminoe, Isao

AU - Kakio, Yuki

AU - Kitagawa, Masashi

AU - Sato, Hajime

AU - Wada, Jun

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objective: We aimed to investigate the relationships among chronic kidney disease (CKD), symptomatic ischaemic stroke, and carotid atherosclerosis. Methods: We enrolled 455 patients who underwent carotid ultrasonography in our hospital, including 311 patients with symptomatic ischaemic stroke and 144 patients without symptomatic ischaemic stroke. Carotid intima–media thickness (IMT), the rate of internal carotid artery stenosis, and maximal plaque size were evaluated. Results: The mean age of the patients was 68.5 ± 11.0 years and the mean estimated glomerular filtration rate (eGFR) was 68.8 ± 18.2 mL/min/1.73 m2. After adjustment for cardiovascular risk factors, the mean IMT was significantly higher in patients with CKD than in those without CKD. The IMT and eGFR were negatively correlated in patients with stroke (r = −0.169). Multiple logistic regression analyses showed that mean IMT, plaque size, and internal carotid artery stenosis were significant determinants of symptomatic ischaemic stroke after adjustment of multivariate risk factors. Furthermore, the eGFR was a negative determinant of symptomatic ischaemic stroke after adjusting for classical risk factors (odds ratio [95% confidence interval] = 0.868 [0.769–0.979]). Conclusion: CKD might be associated with the carotid atherosclerosis and symptomatic ischaemic stroke.

AB - Objective: We aimed to investigate the relationships among chronic kidney disease (CKD), symptomatic ischaemic stroke, and carotid atherosclerosis. Methods: We enrolled 455 patients who underwent carotid ultrasonography in our hospital, including 311 patients with symptomatic ischaemic stroke and 144 patients without symptomatic ischaemic stroke. Carotid intima–media thickness (IMT), the rate of internal carotid artery stenosis, and maximal plaque size were evaluated. Results: The mean age of the patients was 68.5 ± 11.0 years and the mean estimated glomerular filtration rate (eGFR) was 68.8 ± 18.2 mL/min/1.73 m2. After adjustment for cardiovascular risk factors, the mean IMT was significantly higher in patients with CKD than in those without CKD. The IMT and eGFR were negatively correlated in patients with stroke (r = −0.169). Multiple logistic regression analyses showed that mean IMT, plaque size, and internal carotid artery stenosis were significant determinants of symptomatic ischaemic stroke after adjustment of multivariate risk factors. Furthermore, the eGFR was a negative determinant of symptomatic ischaemic stroke after adjusting for classical risk factors (odds ratio [95% confidence interval] = 0.868 [0.769–0.979]). Conclusion: CKD might be associated with the carotid atherosclerosis and symptomatic ischaemic stroke.

KW - carotid atherosclerosis

KW - Chronic kidney disease (CKD)

KW - glomerular filtration rate (GFR)

KW - intima–media thickness (IMT)

KW - ischaemic stroke

KW - ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=85053666738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053666738&partnerID=8YFLogxK

U2 - 10.1177/0300060518781619

DO - 10.1177/0300060518781619

M3 - Article

C2 - 29968487

AN - SCOPUS:85053666738

VL - 46

SP - 3873

EP - 3883

JO - Journal of International Medical Research

JF - Journal of International Medical Research

SN - 0300-0605

IS - 9

ER -