Chronic graft-versus-host disease: Disease biology and novel therapeutic strategies

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12 Citations (Scopus)

Abstract

Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation. Chronic GVHD often presents with clinical manifestations that resemble those observed in autoimmune diseases. Standard treatment is 1-2mg/kg/day of prednisone or an equivalent dose of methylprednisolone, with continued administration of a calcineurin inhibitor for steroid sparing. However, the prognosis of steroid-refractory chronic GVHD remains poor. Classically, chronic GVHD was said to involve predominantly Th2 responses. We are now faced with a more complex picture, involving possible roles for thymic dysfunction, transforming growth factor-β (TGF-ß) and platelet-derived growth factor (PDGF), B cells and autoantibodies, and Th1/Th2/Th7 cytokines, as well as regulatory T cells (Tregs), in chronic GVHD. More detailed research on the pathophysiology of chronic GVHD may facilitate the establishment of novel strategies for its prevention and treatment.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalActa medica Okayama
Volume67
Issue number1
Publication statusPublished - Apr 10 2013

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Keywords

  • Am80
  • Chronic GVHD
  • Regulatory T cell (Treg)
  • Steroid-refractory
  • Thl7

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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