TY - JOUR
T1 - Chronic forced swim stress of rats increases frontal cortical 5-HT2 receptors and the wet-dog shakes they mediate, but not frontal cortical β-adrenoceptors
AU - Takao, Katsuyuki
AU - Nagatani, Tadashi
AU - Kitamura, Yoshihisa
AU - Kawasaki, Koh
AU - Hayakawa, Hiroshi
AU - Yamawaki, Shigeto
PY - 1995/12/29
Y1 - 1995/12/29
N2 - We studied the effects of chronic forced swim stress on 5-HT2 receptors and β-adrenoceptors in the rat frontal cortex. The number of 5-HT2 receptors was increased immediately after the last chronic stress, but not after an acute stress. In vivo, the number of wet-dog shakes induced by a 5-HT2 receptor agonist, (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), was increased 24 h after the last chronic stress. However, the concentrations of 5-HT and 5-hydroxyindole acetic acid (5-HIAA), measured by high pressure liquid chromatography (HPLC), were not altered by this stress. Binding sites for [3H]CGP-12177, i.e., β-adrenoceptor sites, were unchanged after both the acute and the chronic stress. These results suggest that, in the rat, the chronic forced swim stress increases the number of frontal cortical 5-HT2 receptors and the number of wet-dog shakes mediated by these receptors, while the number of frontal cortical β-adrenoceptors is not increased by this treatment.
AB - We studied the effects of chronic forced swim stress on 5-HT2 receptors and β-adrenoceptors in the rat frontal cortex. The number of 5-HT2 receptors was increased immediately after the last chronic stress, but not after an acute stress. In vivo, the number of wet-dog shakes induced by a 5-HT2 receptor agonist, (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), was increased 24 h after the last chronic stress. However, the concentrations of 5-HT and 5-hydroxyindole acetic acid (5-HIAA), measured by high pressure liquid chromatography (HPLC), were not altered by this stress. Binding sites for [3H]CGP-12177, i.e., β-adrenoceptor sites, were unchanged after both the acute and the chronic stress. These results suggest that, in the rat, the chronic forced swim stress increases the number of frontal cortical 5-HT2 receptors and the number of wet-dog shakes mediated by these receptors, while the number of frontal cortical β-adrenoceptors is not increased by this treatment.
KW - 5-HT receptor
KW - Forced swim test
KW - Stress
KW - Wet-dog shake
KW - β-Adrenoceptor
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U2 - 10.1016/0014-2999(95)00620-6
DO - 10.1016/0014-2999(95)00620-6
M3 - Article
C2 - 8750738
AN - SCOPUS:0029582743
VL - 294
SP - 721
EP - 726
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -