Chronic effects of transient forebrain ischemia on monoamines in the spontaneously hypertensive rat brain

S. Nishibayashi, M. Asanuma, Yoichi Kondo, E. Iwata, Koji Matsuura, Toshio Ogura, N. Ogawa

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1 Citation (Scopus)


Using the 3-hr common carotid occlusion model in spontaneously hypertensive rats (SHRs), we investigated the changes in monoamines and their metabolites up to the chronic phase, 6 months alter the transient forebrain ischemia, in various brain regions. In the striatum, the levels of dopamine (DA) at the 3rd week and serotonin (5-HT) at the 2nd week were 1.6-fold and 2.4-fold higher than the levels in the respective sham-operated controls coinciding with increases in their metabolites, homovanillic acid and 5-hydroxyindoleacetic acid. However, these marked increases in both transmitter; were transient aid their levels recovered to the sham-operated levels. This transient increase in DA release in the striatum may be caused by ischemia-induced disruption of nerve endings, and may aggravate tissue damage in the striatum at the chronic phase after ischemia. Transient or lasting changes in noradrenaline, DA, 5-HT and their metabolites were also observed in other brain regions, the thalamus+midbrain and the hippocampus of SHRs after transient ischemia. These ischemia-induced alterations in monoamines at the chronic phase may be partly involved in die late-onset sequelae seen in the cerebrovascular disorders.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalBiogenic Amines
Issue number2
Publication statusPublished - 1995


  • Brain
  • Forebrain ischemia
  • Monoamine
  • Spontaneously hypertensive rats

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology


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