Chronic cerebral hypoperfusion induces striatal alterations due to the transient increase of NO production and the depression of glutathione content

K. I. Tanaka, N. Wada-Tanaka, Ikuko Miyazaki, M. Nomura, N. Ogawa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We examined the effects of chronic cerebral hypoperfusion on the endogenous oxidative stress-related indices, nitrite and nitrate (NOx) concentration, glutathione (GSH) content, superoxide dismutase and catalase activities, and thiobarbituric acid-reactive substances level in the rat striatum, to clarify the participation of oxidative stress in the chronic cerebral hypoperfusion-induced alterations. Our present results indicate that chronic cerebral hypoperfusion produces oxidative stress and disturbs intracellular redox regulation in two distinct phases: at 1 day, "acute" and at 6 weeks, "chronic" alterations after the operation. Therefore, striatal neural cell damage may be mainly attributed to the transient increase of NOx production at 1 day after, and the delayed reduction of muscarinic acetylcholine receptor binding in the striatum may be mostly attributed to the continuous depression of GSH content from the 1st to the 6th post-operative week. In particular, the continuous GSH depression may be considered to accompany the pathophysiology of chronic cerebral hypoperfusion.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalNeurochemical Research
Volume27
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint

Corpus Striatum
Oxidative stress
Glutathione
Oxidative Stress
Thiobarbituric Acid Reactive Substances
Muscarinic Receptors
Nitrites
Nitrates
Catalase
Superoxide Dismutase
Oxidation-Reduction
Rats
Cells

Keywords

  • Catalase
  • Glutathione
  • Lipid peroxidation
  • Nitric oxide
  • Oxidative stress
  • SOD

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Chronic cerebral hypoperfusion induces striatal alterations due to the transient increase of NO production and the depression of glutathione content. / Tanaka, K. I.; Wada-Tanaka, N.; Miyazaki, Ikuko; Nomura, M.; Ogawa, N.

In: Neurochemical Research, Vol. 27, No. 4, 2002, p. 331-336.

Research output: Contribution to journalArticle

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AU - Ogawa, N.

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