Chronic bifemelane hydrochloride administration enhances muscarinic cholinergic receptor binding in the senescent rat brain

N. Ogawa, K. Mizukawa, K. Haba, Masato Asanuma, A. Mori

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In senescent rats, the binding ability of muscarinic cholinergic receptors (MCR) was markedly decreased in the cerebral cortex, hippocampus, thalamus, and the striatum compared with young adult rats. This decrease was markedly improved by chronic administration of bifemelane hydrochloride (bifemelane). In view of the findings that bifemelane markedly inhibits the decrease in acetylcholine (ACh) associated with cerebral ischemia, and that it improves amnesia induced by scopalamine, it may be inferred that bifemelane acts on the pre- and post-synaptic ACh neuronal systems. It may improve memory disturbance due to aging or cerebral ischemia, decreased conscious level, and decreased motor function.

Original languageEnglish
Pages (from-to)17-27
Number of pages11
JournalJournal of Medicine
Volume22
Issue number1
Publication statusPublished - 1991

Fingerprint

Cholinergic Receptors
Muscarinic Receptors
Brain
Brain Ischemia
Acetylcholine
Aptitude
Amnesia
Thalamus
Cerebral Cortex
Young Adult
Hippocampus
bifemelane

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chronic bifemelane hydrochloride administration enhances muscarinic cholinergic receptor binding in the senescent rat brain. / Ogawa, N.; Mizukawa, K.; Haba, K.; Asanuma, Masato; Mori, A.

In: Journal of Medicine, Vol. 22, No. 1, 1991, p. 17-27.

Research output: Contribution to journalArticle

@article{9ee60611703a417086670a8de907983d,
title = "Chronic bifemelane hydrochloride administration enhances muscarinic cholinergic receptor binding in the senescent rat brain",
abstract = "In senescent rats, the binding ability of muscarinic cholinergic receptors (MCR) was markedly decreased in the cerebral cortex, hippocampus, thalamus, and the striatum compared with young adult rats. This decrease was markedly improved by chronic administration of bifemelane hydrochloride (bifemelane). In view of the findings that bifemelane markedly inhibits the decrease in acetylcholine (ACh) associated with cerebral ischemia, and that it improves amnesia induced by scopalamine, it may be inferred that bifemelane acts on the pre- and post-synaptic ACh neuronal systems. It may improve memory disturbance due to aging or cerebral ischemia, decreased conscious level, and decreased motor function.",
author = "N. Ogawa and K. Mizukawa and K. Haba and Masato Asanuma and A. Mori",
year = "1991",
language = "English",
volume = "22",
pages = "17--27",
journal = "Journal of Medicine",
issn = "0025-7850",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Chronic bifemelane hydrochloride administration enhances muscarinic cholinergic receptor binding in the senescent rat brain

AU - Ogawa, N.

AU - Mizukawa, K.

AU - Haba, K.

AU - Asanuma, Masato

AU - Mori, A.

PY - 1991

Y1 - 1991

N2 - In senescent rats, the binding ability of muscarinic cholinergic receptors (MCR) was markedly decreased in the cerebral cortex, hippocampus, thalamus, and the striatum compared with young adult rats. This decrease was markedly improved by chronic administration of bifemelane hydrochloride (bifemelane). In view of the findings that bifemelane markedly inhibits the decrease in acetylcholine (ACh) associated with cerebral ischemia, and that it improves amnesia induced by scopalamine, it may be inferred that bifemelane acts on the pre- and post-synaptic ACh neuronal systems. It may improve memory disturbance due to aging or cerebral ischemia, decreased conscious level, and decreased motor function.

AB - In senescent rats, the binding ability of muscarinic cholinergic receptors (MCR) was markedly decreased in the cerebral cortex, hippocampus, thalamus, and the striatum compared with young adult rats. This decrease was markedly improved by chronic administration of bifemelane hydrochloride (bifemelane). In view of the findings that bifemelane markedly inhibits the decrease in acetylcholine (ACh) associated with cerebral ischemia, and that it improves amnesia induced by scopalamine, it may be inferred that bifemelane acts on the pre- and post-synaptic ACh neuronal systems. It may improve memory disturbance due to aging or cerebral ischemia, decreased conscious level, and decreased motor function.

UR - http://www.scopus.com/inward/record.url?scp=0025905333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025905333&partnerID=8YFLogxK

M3 - Article

C2 - 2072048

AN - SCOPUS:0025905333

VL - 22

SP - 17

EP - 27

JO - Journal of Medicine

JF - Journal of Medicine

SN - 0025-7850

IS - 1

ER -