Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemia- induced changes in brain indoleamine metabolism and muscarinic receptor binding in the mongolian gerbil

H. Kabuto, Masato Asanuma, S. Nishibayashi, M. Iida, N. Ogawa

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Abstract

We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pro- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalNeurochemical Research
Volume22
Issue number1
DOIs
Publication statusPublished - 1997

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Keywords

  • acetylcholine
  • monoamine metabolism
  • muscarinic receptor
  • Oren-gedoku-to (TJ15)
  • serotonin
  • Transient ischemia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

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