Chronic administration of oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the mongolian gerbil

Hideaki Kabuto, Masato Asanuma, Sakiko Nishibayashi, Motoyuki Lida, Norio Ogawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalNeurochemical Research
Volume22
Issue number1
DOIs
Publication statusPublished - 1997

Keywords

  • Acctylcholine
  • Monoamine metabolism
  • Muscarinic receptor
  • Oren-gedoku-to (TJ15)
  • Serotonin
  • Transient ischemia

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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