Abstract
Background: Epidemiologic studies suggest a relationship between periodontitis and liver diseases. A rat periodontitis model was used to investigate whether a causal relationship exists between periodontitis and liver diseases. Methods: Fourteen male Wistar rats (8 weeks old) were divided into two groups: a periodontitis group in which Escherichia coli lipopolysaccharide (LPS) and Streptomyces griseus proteases were applied into the gingival sulcus for 8 weeks, and a control group using pyrogen-free water instead. After blood samples were collected, periodontal tissues and liver specimens were analyzed. Results: Chronic administration of LPS and proteases to the gingival sulcus induced periodontitis and liver injury, including steatosis with inflammation and sinusoidal fibrosis. Apoptosis, enhanced concentration of 8-hydroxydeoxyguanosine, and activated production of tumor necrosis factor-alpha in liver were observed in the periodontitis group, with increased gingival inflammation, serum LPS, and reactive oxygen species. Conclusion: Periodontal inflammation in a rat model induced fatty liver disease through increased serum LPS.
Original language | English |
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Pages (from-to) | 1999-2006 |
Number of pages | 8 |
Journal | Journal of periodontology |
Volume | 78 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2007 |
Keywords
- Animals
- Fatty liver
- Hepatic steatosis
- Lipopolysaccharides
- Periodontitis
ASJC Scopus subject areas
- Periodontics