Chronic administration of acetylcholinesterase inhibitor in the senescent Rat brain

K. Tanaka, N. Ogawa, M. Asanuma, Yoichi Kondo, A. Mori

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The effects of chronic administration of ENA-713, an acetylcholinesterase (AChE) inhibitor, on pre- and postsynaptic cholinergic indices were examined in the senescent rat brain. In the senescent group, the acetylcholine (ACh) level was markedly reduced in the frontal cortex, hippocampus, striatum and thalamus + midbrain, but these reductions were completely prevented by ENA-713. Moreover, although choline acetyltransferase (ChAT) activity was also significantly decreased in these four regions, it recovered in the frontal cortex, hippocampus and thalamus + midbrain after ENA-713 treatment. In contrast, cholinesterase (ChE) activity was not changed in any experimental groups. The maximum number (Bmax) of muscarinic M1 receptor (M1-R) binding site in the frontal cortex in the senescent group was decreased without any change in affinity, but this decrease was also inhibited by ENA-713. Thus, these findings suggest that ENA-713 may have protective, neurotrophic and therapeutic effects on aging-induced cholinergic dysfunction and be useful for the treatment of aging-related dementia, such as the Alzheimer-type dementia.

Original languageEnglish
Pages (from-to)721-725
Number of pages5
JournalNeurobiology of Aging
Volume15
Issue number6
DOIs
Publication statusPublished - Jan 1 1994

Keywords

  • Acetylcholinesterase inhibitor
  • Cholinergic indices
  • Chronic administration
  • ENA-713
  • Fischer 344
  • Normal aging
  • Senescent rat brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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