Choroidal schwannoma

Immunohistochemical and electron-microscopic study

Toshihiko Matsuo, Kenji Notohara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Schwannoma (neurilemoma) arising from the ciliary body and choroid is a rare form of intraocular tumor and usually misdiagnosed clinically as amelanotic melanoma. This case report describes a 73-year-old woman who developed a large nonpigmented intraocular tumor of the choroid in the left eye and underwent enucleation with a clinical diagnosis of malignant melanoma. The tumor consisted of spindle-shaped cells with an indefinite cytoplasm and twisted nuclei, which had positive immunoreactivity for S-100 protein, vimentin, glial fibrillary acidic protein and neural cell adhesion molecule. A continuous basal lamina encompassing the tumor cells was demonstrated by immunostaining for laminin and type IV collagen. Ultrastructurally, tumor cells with scant organelles had delicate cytoplasmic processes apposing each other, all indicative of Schwann cell origin. In reexamination of fluorescein angiograms, ultrasonograms and magnetic resonance images, no findings were incompatible with a diagnosis of choroidal melanoma. Histopathological studies showed that the tumor was a schwannoma. At present, we do not have a benchmark for the clinical diagnosis of intraocular schwannoma. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalOphthalmologica
Volume214
Issue number2
Publication statusPublished - Mar 2000

Fingerprint

Neurilemmoma
Electrons
Neoplasms
Choroid
Melanoma
Eye Enucleation
Amelanotic Melanoma
Benchmarking
Neural Cell Adhesion Molecules
Ciliary Body
Collagen Type IV
S100 Proteins
Schwann Cells
Glial Fibrillary Acidic Protein
Laminin
Vimentin
Diagnostic Errors
Fluorescein
Basement Membrane
Organelles

Keywords

  • Choroidal schwannoma
  • Electron microscopy
  • Immunohistochemistry

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Choroidal schwannoma : Immunohistochemical and electron-microscopic study. / Matsuo, Toshihiko; Notohara, Kenji.

In: Ophthalmologica, Vol. 214, No. 2, 03.2000, p. 156-160.

Research output: Contribution to journalArticle

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