Cholinergic deficits in aged rat brain are corrected with nicergoline

N. Ogawa, M. Asanuma, H. Hirata, Yoichi Kondo, Y. Kawada, A. Mori

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Choline acetyltransferase (CAT) and muscarinic cholinergic receptor (MCR) activities are markedly reduced in aged as compared with young-adult rat brain. Nicergoline was found to correct these reduced activities in most regions of the brain, especially in the cerebral cortex and hippocampus. Chronic administration of nicergoline had no effect on CAT activity or MCR binding in young-adult rat brain. Nicergoline thus appears to have a specific therapeutic effect on cholinergic functions in aged rat brain, where it acts both pre-synaptically and post-synaptically.

Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalArchives of Gerontology and Geriatrics
Volume16
Issue number2
DOIs
Publication statusPublished - Jan 1 1993

Keywords

  • Aged rat brain
  • Brain regions
  • Choline acetyltransferase
  • Muscarinic cholinergic receptor
  • Nicergoline

ASJC Scopus subject areas

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

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