Cholesteryl ester transfer protein expressed in lecithin cholesterol acyltransferase-deficient mice

Cheng Ai Wu, Maki Tsujita, Kuniko Okumura-Noji, Shinichi Usui, Hajime Kakuuchi, Mitsuyo Okazaki, Shinji Yokoyama

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective - Regulation of plasma cholesteryl ester transfer protein (CETP) concentration was studied in lecithin-cholesterol acyltransferase (LCAT)-knockout mice. Methods and Results - LCAT-knockout mice were cross-bred with CETP transgenic mice. The offspring (n=63) were classified for LCAT genotype and plasma CETP levels (no CETP, low CETP, and high CETP). High density lipoprotein (HDL) decreased as LCAT decreased in each CETP-level group. In the lcat(+/+) and lcat(+/-) mice, plasma CETP varied from 0 to 30 μg/mL, whereas it was

Original languageEnglish
Pages (from-to)1347-1353
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume22
Issue number8
DOIs
Publication statusPublished - 2002
Externally publishedYes

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Cholesterol Ester Transfer Proteins
Phosphatidylcholine-Sterol O-Acyltransferase
Blood Proteins
Knockout Mice
HDL Lipoproteins
Transgenic Mice
Genotype

Keywords

  • Cholesterol
  • Cholesteryl ester transfer protein
  • High density lipoprotein
  • Lecithin-cholesterol acyltransferase
  • Mice

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cholesteryl ester transfer protein expressed in lecithin cholesterol acyltransferase-deficient mice. / Wu, Cheng Ai; Tsujita, Maki; Okumura-Noji, Kuniko; Usui, Shinichi; Kakuuchi, Hajime; Okazaki, Mitsuyo; Yokoyama, Shinji.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 22, No. 8, 2002, p. 1347-1353.

Research output: Contribution to journalArticle

Wu, Cheng Ai ; Tsujita, Maki ; Okumura-Noji, Kuniko ; Usui, Shinichi ; Kakuuchi, Hajime ; Okazaki, Mitsuyo ; Yokoyama, Shinji. / Cholesteryl ester transfer protein expressed in lecithin cholesterol acyltransferase-deficient mice. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2002 ; Vol. 22, No. 8. pp. 1347-1353.
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AU - Wu, Cheng Ai

AU - Tsujita, Maki

AU - Okumura-Noji, Kuniko

AU - Usui, Shinichi

AU - Kakuuchi, Hajime

AU - Okazaki, Mitsuyo

AU - Yokoyama, Shinji

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