Chiral zirconium alkoxides-mediated asymmetric Meerwein-Ponndorf-Verley cyanation of aldehydes

T. Ooi, K. Takaya, T. Miura, H. Ichikawa, K. Maruoka

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Chiral zirconium alkoxides prepared in situ from Zr(OBu(t))4, TADDOL and acetone cyanohydrin in CH2Cl2 effect the enantioselective Meerwein-Ponndorf-Verley cyanation of alde-hydes, giving optically active cyanohydrins. The reaction proceeds catalytically with the aid of activated, powdered 4 molecular sieves.

Original languageEnglish
Pages (from-to)1133-1134
Number of pages2
JournalSynlett
Issue number8
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Acetone cyanohydrin
  • Aldehydes
  • Chiral zirconium alkoxides
  • Meerwein-Ponndorf-Verley cyanation
  • Optically active cyanohydrin

ASJC Scopus subject areas

  • Organic Chemistry

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