Chiral zirconium alkoxides-mediated asymmetric Meerwein-Ponndorf-Verley cyanation of aldehydes

T. Ooi; K. Takaya; T. Miura; H. Ichikawa; K. Maruoka

Chiral zirconium alkoxides-mediated asymmetric Meerwein-Ponndorf-Verley cyanation of aldehydes

T. Ooi, K. Takaya, T. Miura, H. Ichikawa, K. Maruoka

Research output: Contribution to journal › Article › peer-review

Abstract

Chiral zirconium alkoxides prepared in situ from Zr(OBu(t))₄, TADDOL and acetone cyanohydrin in CH₂Cl₂ effect the enantioselective Meerwein-Ponndorf-Verley cyanation of alde-hydes, giving optically active cyanohydrins. The reaction proceeds catalytically with the aid of activated, powdered 4 molecular sieves.

Original language	English
Pages (from-to)	1133-1134
Number of pages	2
Journal	Synlett
Issue number	8
Publication status	Published - 2000
Externally published	Yes

Keywords

Acetone cyanohydrin
Aldehydes
Chiral zirconium alkoxides
Meerwein-Ponndorf-Verley cyanation
Optically active cyanohydrin

ASJC Scopus subject areas

Organic Chemistry

Cite this

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title = "Chiral zirconium alkoxides-mediated asymmetric Meerwein-Ponndorf-Verley cyanation of aldehydes",

abstract = "Chiral zirconium alkoxides prepared in situ from Zr(OBu(t))4, TADDOL and acetone cyanohydrin in CH2Cl2 effect the enantioselective Meerwein-Ponndorf-Verley cyanation of alde-hydes, giving optically active cyanohydrins. The reaction proceeds catalytically with the aid of activated, powdered 4 molecular sieves.",

keywords = "Acetone cyanohydrin, Aldehydes, Chiral zirconium alkoxides, Meerwein-Ponndorf-Verley cyanation, Optically active cyanohydrin",

author = "T. Ooi and K. Takaya and T. Miura and H. Ichikawa and K. Maruoka",

year = "2000",

language = "English",

pages = "1133--1134",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "8",

}

TY - JOUR

T1 - Chiral zirconium alkoxides-mediated asymmetric Meerwein-Ponndorf-Verley cyanation of aldehydes

AU - Ooi, T.

AU - Takaya, K.

AU - Miura, T.

AU - Ichikawa, H.

AU - Maruoka, K.

PY - 2000

Y1 - 2000

N2 - Chiral zirconium alkoxides prepared in situ from Zr(OBu(t))4, TADDOL and acetone cyanohydrin in CH2Cl2 effect the enantioselective Meerwein-Ponndorf-Verley cyanation of alde-hydes, giving optically active cyanohydrins. The reaction proceeds catalytically with the aid of activated, powdered 4 molecular sieves.

AB - Chiral zirconium alkoxides prepared in situ from Zr(OBu(t))4, TADDOL and acetone cyanohydrin in CH2Cl2 effect the enantioselective Meerwein-Ponndorf-Verley cyanation of alde-hydes, giving optically active cyanohydrins. The reaction proceeds catalytically with the aid of activated, powdered 4 molecular sieves.

KW - Acetone cyanohydrin

KW - Aldehydes

KW - Chiral zirconium alkoxides

KW - Meerwein-Ponndorf-Verley cyanation

KW - Optically active cyanohydrin

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UR - http://www.scopus.com/inward/citedby.url?scp=0033891398&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0033891398

SP - 1133

EP - 1134

JO - Synlett

JF - Synlett

SN - 0936-5214

IS - 8

ER -

Chiral zirconium alkoxides-mediated asymmetric Meerwein-Ponndorf-Verley cyanation of aldehydes

Abstract

Keywords

ASJC Scopus subject areas

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