Abstract
Chiral zirconium alkoxides prepared in situ from Zr(OBu(t))4, TADDOL and acetone cyanohydrin in CH2Cl2 effect the enantioselective Meerwein-Ponndorf-Verley cyanation of alde-hydes, giving optically active cyanohydrins. The reaction proceeds catalytically with the aid of activated, powdered 4 molecular sieves.
Original language | English |
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Pages (from-to) | 1133-1134 |
Number of pages | 2 |
Journal | Synlett |
Issue number | 8 |
Publication status | Published - 2000 |
Externally published | Yes |
Keywords
- Acetone cyanohydrin
- Aldehydes
- Chiral zirconium alkoxides
- Meerwein-Ponndorf-Verley cyanation
- Optically active cyanohydrin
ASJC Scopus subject areas
- Organic Chemistry